Results 31 to 40 of about 16,792 (188)

Syndecans in Inflammation at a Glance

Frontiers in Immunology, 2020
Syndecans are transmembrane proteoglycans with heparan and chondroitin sulfate chains attached to their extracellular domain. Like many proteoglycans, they interact with a large number of ligands, such as growth factors, adhesion receptors, soluble small
Sandeep Gopal
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Internalization and trafficking of CSPG-bound recombinant VAR2CSA lectins in cancer cells

Scientific Reports, 2022
Proteoglycans are proteins that are modified with glycosaminoglycan chains. Chondroitin sulfate proteoglycans (CSPGs) are currently being exploited as targets for drug-delivery in various cancer indications, however basic knowledge on how CSPGs are ...
Chris Kedong Wang, Irina Nelepcu, Desmond Hui, Htoo Zarni Oo, Sarah Truong, Sarah Zhao, Zakir Tahiry, Shaghayegh Esfandnia, Fariba Ghaidi, Hans Adomat, Robert Dagil, Tobias Gustavsson, Swati Choudhary, Ali Salanti, Poul H. Sorensen, Nader Al Nakouzi, Mads Daugaard   +16 more
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Expanding the Chondroitin Sulfate Glycoproteome — But How Far?

Frontiers in Cell and Developmental Biology, 2021
Chondroitin sulfate proteoglycans (CSPGs) are found at cell surfaces and in connective tissues, where they interact with a multitude of proteins involved in various pathophysiological processes.
Fredrik Noborn, Mahnaz Nikpour, Andrea Persson, Jonas Nilsson, Jonas Nilsson, Göran Larson   +5 more
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Soluble heparin proteoglycans released from stimulated mast cells induce uptake of low density lipoproteins by macrophages via scavenger receptor-mediated phagocytosis.

Journal of Lipid Research, 1992
Stimulation of rat serosal mast cells in vitro triggers exocytosis of secretory granules from their cytoplasm. Thereupon, the granules lose their perigranular membranes, and about 40% of the heparin proteoglycans and all of the chondroitin sulfate ...
KA Lindstedt, JO Kokkonen, PT Kovanen
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Oncofetal Chondroitin Sulfate: A Putative Therapeutic Target in Adult and Pediatric Solid Tumors

Cells, 2020
Solid tumors remain a major challenge for targeted therapeutic intervention strategies such as antibody-drug conjugates and immunotherapy. At a minimum, clear and actionable solid tumor targets have to comply with the key biological requirement of being ...
Nastaran Khazamipour, Nader Al-Nakouzi, Htoo Zarni Oo, Maj Ørum-Madsen, Anne Steino, Poul H Sorensen, Mads Daugaard   +6 more
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Glypican-1, Phosphacan/Receptor Protein-Tyrosine Phosphatase-ζ/β and its Ligand, Tenascin-C, are Expressed by Neural Stem Cells and Neural Cells Derived from Embryonic Stem Cells

ASN Neuro, 2010
The heparan sulfate proteoglycan glypican-1, the chondroitin sulfate proteoglycan phosphacan/RPTP (receptor protein-tyrosine phosphatase)-ζ/β and the extracellular matrix protein tenascin-C were all found to be expressed by neural stem cells and by ...
Mary Abaskharoun, Marie Bellemare, Elizabeth Lau, Richard U Margolis   +3 more
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Agrin and perlecan mediate tumorigenic processes in oral squamous cell carcinoma. [PDF]

PLoS ONE, 2014
Oral squamous cell carcinoma is the most common type of cancer in the oral cavity, representing more than 90% of all oral cancers. The characterization of altered molecules in oral cancer is essential to understand molecular mechanisms underlying tumor ...
Rebeca Kawahara, Daniela C Granato, Carolina M Carnielli, Nilva K Cervigne, Carine E Oliveria, César Rivera, Sami Yokoo, Felipe P Fonseca, Marcio Lopes, Alan R Santos-Silva, Edgard Graner, Ricardo D Coletta, Adriana Franco Paes Leme   +12 more
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N-acetylgalactosamine positive perineuronal nets in the saccade-related-part of the cerebellar fastigial nucleus do not maintain saccade gain. [PDF]

PLoS ONE, 2014
Perineuronal nets (PNNs) accumulate around neurons near the end of developmental critical periods. PNNs are structures of the extracellular matrix which surround synaptic contacts and contain chondroitin sulfate proteoglycans.
Adrienne Mueller, Adam Davis, Steven S Carlson, Farrel R Robinson   +3 more
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Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin

Journal of Inflammation, 2006
Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology.
Patsch Josef R, Ricevuti Giovanni, Ross Christopher R, Kaneider Nicole C, Mosheimer Birgit, Djanani Angela, Wiedermann Christian J   +6 more
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Trends in the application of chondroitinase ABC in injured spinal cord repair

Neural Regeneration Research
Spinal cord injuries have overwhelming physical and occupational implications for patients. Moreover, the extensive and long-term medical care required for spinal cord injury significantly increases healthcare costs and resources, adding a substantial ...
Zhongqing Ji, Jiangfeng Zhu, Jinming Liu, Bin Wei, Yixin Shen, Yanan Hu   +5 more
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