Versican modulates tumor-associated macrophage properties to stimulate mesothelioma growth
OncoImmunology, 2019 Versican promotes experimental tumor growth through cell- and non cell-autonomous mechanisms. Its role in mesothelioma progression has not been investigated so far.
Apostolos G. Pappas +8 more
doaj +1 more source
Different mRNA and Protein Expression of Versican in TGF-β1-treated Prostate Cancer Cells
Forbes Tıp Dergisi, 2022 Objective: Cellular heterogeneity of tumors stems from cell populations expressing a unique set of proteins defective genetic and epigenetic networks.
Burak SONER +5 more
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The biochemistry and immunohistochemistry of versican [PDF]
, 2018 Versican is a chondroitin sulfate proteoglycan found in the extracellular matrix that is important for changes in cell phenotype associated with development and disease. Versican has been shown to be involved in cardiovascular disorders, as well as lung disease and fibrosis, inflammatory bowel disease, cancer, and several other diseases that have an ...
Stephen P, Evanko +4 more
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ADAMTS9-regulated pericellular matrix dynamics governs focal adhesion-dependent smooth muscle differentiation [PDF]
, 2018 Focal adhesions anchor cells to extracellular matrix (ECM) and direct assembly of a pre-stressed actin cytoskeleton. They act as a cellular sensor and regulator, linking ECM to the nucleus.
Apte, S.S. +8 more
core +2 more sources
Repression of Versican Expression by MicroRNA-143 [PDF]
Journal of Biological Chemistry, 2010 Smooth muscle cells (SMCs) retain remarkable plasticity to undergo phenotypic modulation in which the expression of smooth muscle markers is markedly attenuated while conversely expression of extracellular matrix (ECM) is dramatically up-regulated. Myocardin is perhaps the most potent transcription factor for stimulating expression of smooth muscle ...
Xiaobo, Wang, Guoqing, Hu, Jiliang, Zhou
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Frontiers in Oncology, 2019 Versican and tumor-associated macrophages (TAMs) are involved in growth and metastases in several cancers. Here, we investigated the potential role of versican, a matrix proteoglycan, and its correlation with TAMs infiltrates in different stages of two ...
Diego Carlos dos Reis +13 more
doaj +1 more source
Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids [PDF]
, 2019 Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation.
Al-Aama, Jumana +15 more
core +2 more sources
Versican and the control of inflammation
Matrix Biology, 2014 Versican is an extracellular matrix (ECM) proteoglycan that interacts with cells by binding to non-integrin and integrin receptors and to other ECM components that associate with the cell surface. Recent studies have shown also that versican interacts with myeloid and lymphoid cells promoting their adhesion and production of inflammatory cytokines ...
Wight, Thomas N. +2 more
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Tendinopathy—from basic science to treatment [PDF]
, 2008 Chronic tendon pathology (tendinopathy), although common, is difficult to treat. Tendons possess a highly organized fibrillar matrix, consisting of type I collagen and various 'minor' collagens, proteoglycans and glycoproteins.
A McCormick +69 more
core +1 more source
Versican vs versikine: tolerance vs attack [PDF]
Blood, 2016 In this issue of Blood, Hope et al demonstrate the differential influence of versican and its proteolytic derivate, versikine, on the immune system.
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