Results 41 to 50 of about 8,199 (176)
Versican: a novel modulator of hepatic fibrosis [PDF]
Laboratory Investigation, 2016 Little is known about the deposition and turnover of proteoglycans in liver fibrosis, despite their abundance in the extracellular matrix. Versican plays diverse roles in modulating cell behavior in other fibroproliferative diseases, but remains poorly described in the liver.
Terence N, Bukong +4 more
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Role of Versican in the Pathogenesis of Peritoneal Endometriosis [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2016 Context: Sampson’s theory cannot explain why only some cycling women develop peritoneal endometriosis. Few studies have focused on the pelvic peritoneum, which receives regurgitated endometrial tissues. We hypothesized that molecular alterations in the peritoneum are involved in the development of peritoneal ...
Hirohiko, Tani +7 more
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Versican Mediates Mesenchymal-Epithelial Transition [PDF]
Molecular Biology of the Cell, 2006 Versican is a large extracellular chondroitin sulfate proteoglycan that belongs to the family of lecticans. Alternative splicing of versican generates at least four isoforms named V0, V1, V2, and V3. We show here that ectopic expression of versican V1 isoform induced mesenchymal-epithelial transition (MET) in NIH3T3 fibroblasts, and inhibition of ...
Wang, Sheng +7 more
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Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy
Molecules, 2022 We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan substrates versican and biglycan in an ocular microenvironment of proliferative diabetic ...
Ahmed M. Abu El-Asrar +7 more
doaj +1 more source
Versican is differentially regulated in the adventitial and medial layers of human vein grafts.
PLoS ONE, 2018 Changes in extracellular matrix proteins may contribute significantly to the adaptation of vein grafts to the arterial circulation. We examined the production and distribution of versican and hyaluronan in intact human vein rings cultured ex vivo, veins ...
Richard D Kenagy +14 more
doaj +1 more source
The interaction of versican with its binding partners [PDF]
Cell Research, 2005 Versican belongs to the family of the large aggregating chondroitin sulfate proteoglycans located primarily within the extracellular matrix (ECM). Versican, like other members of its family, has unique N- and C-terminal globular regions, each with multiple motifs. A large glycosaminoglycan-binding region lies between them.
Yao Jiong, Wu +4 more
openaire +2 more sources
Nature Communications, 2022 Ghorbani and colleagues describe versican-V1 as an inhibitor of remyelination using transgenic mice that illuminate new GFP + oligodendrocytes. Mechanisms of versican-V1 include the direct inhibition of oligodendrocytes, and elevating Th17 cells.
Samira Ghorbani +16 more
doaj +1 more source
Repression of Versican Expression by MicroRNA-143 [PDF]
Journal of Biological Chemistry, 2010 Smooth muscle cells (SMCs) retain remarkable plasticity to undergo phenotypic modulation in which the expression of smooth muscle markers is markedly attenuated while conversely expression of extracellular matrix (ECM) is dramatically up-regulated. Myocardin is perhaps the most potent transcription factor for stimulating expression of smooth muscle ...
Xiaobo, Wang, Guoqing, Hu, Jiliang, Zhou
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Versican modulates tumor-associated macrophage properties to stimulate mesothelioma growth
OncoImmunology, 2019 Versican promotes experimental tumor growth through cell- and non cell-autonomous mechanisms. Its role in mesothelioma progression has not been investigated so far.
Apostolos G. Pappas +8 more
doaj +1 more source
Different mRNA and Protein Expression of Versican in TGF-β1-treated Prostate Cancer Cells
Forbes Tıp Dergisi, 2022 Objective: Cellular heterogeneity of tumors stems from cell populations expressing a unique set of proteins defective genetic and epigenetic networks.
Burak SONER +5 more
doaj +1 more source