Results 41 to 50 of about 10,151 (207)

Role of Versican in Epithelial Ovarian Carcinoma [PDF]

, 2013
Epithelial ovarian carcinoma (EOC) is a leading cause of death from gynecologic malignancies, and the fifth leading cause of death in women. The extracellular matrix plays a key role in regulating cellular activities such as proliferation, adhesion ...
Mark Desjardins (7988639)
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The interaction of versican with its binding partners [PDF]

Cell Research, 2005
Versican belongs to the family of the large aggregating chondroitin sulfate proteoglycans located primarily within the extracellular matrix (ECM). Versican, like other members of its family, has unique N- and C-terminal globular regions, each with multiple motifs. A large glycosaminoglycan-binding region lies between them.
Yao Jiong, Wu, David P, La Pierre, Jin, Wu, Albert J, Yee, Burton B, Yang   +4 more
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Versican is induced in infiltrating monocytes in myocardial infarction [PDF]

, 2005
Versican, a large chondroitin sulfate proteoglycan, plays a role in conditions such as wound healing and tissue remodelling. To test the hypothesis that versican expression is transiently upregulated and plays a role in the infarcted heart, we examined ...
Demircan, Kadir, Ninomiya, Yoshifumi, Nakamura, Keigo, Yamawaki, Hitoshi, Shiratori, Yasushi, Hatipoglu, Omer F., Hirohata, Satoshi, Toeda, Kenichi, Ogawa, Hiroko, Kusachi, Shozo   +9 more
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Repression of Versican Expression by MicroRNA-143 [PDF]

Journal of Biological Chemistry, 2010
Smooth muscle cells (SMCs) retain remarkable plasticity to undergo phenotypic modulation in which the expression of smooth muscle markers is markedly attenuated while conversely expression of extracellular matrix (ECM) is dramatically up-regulated. Myocardin is perhaps the most potent transcription factor for stimulating expression of smooth muscle ...
Xiaobo, Wang, Guoqing, Hu, Jiliang, Zhou
openaire   +2 more sources

Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee

, 2007
Expansion of the extracellular matrix is a prominent but poorly characterized feature of tendinosis. The present study aimed to characterize the extent and distribution of the large aggregating proteoglycan versican in patients with patellar tendinosis ...
C. R. Roberts, Scott, A., Duronio, V., Khan, K. M., Samiric, Tom, A. Scott, Roberts, C. R., Parkinson, J., J. L. Cook, R. Bahr, Lian, O., Cook, J. L., Illic, Mirna Z., Cook, Jill L., M. Z. Ilic, D. A. Hart, C. J. Handley, K. M. Khan, Handley, C. J., T. Samiric, Scott, Alexander, Bahr, Roald, Lian, Øystein, Handley, Christopher J., Samiric, T., Hart, David A., Bahr, R., J. Parkinson, Khan, Karim M., Roberts, Clive C., Ø. Lian, Duronio, Vincent, V. Duronio, Parkinson, John, Ilic, M. Z., Hart, D. A.   +35 more
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Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination

Nature Communications, 2022
Ghorbani and colleagues describe versican-V1 as an inhibitor of remyelination using transgenic mice that illuminate new GFP + oligodendrocytes. Mechanisms of versican-V1 include the direct inhibition of oligodendrocytes, and elevating Th17 cells.
Samira Ghorbani, Emily Jelinek, Rajiv Jain, Benjamin Buehner, Cenxiao Li, Brian M. Lozinski, Susobhan Sarkar, Deepak K. Kaushik, Yifei Dong, Thomas N. Wight, Soheila Karimi-Abdolrezaee, Geert J. Schenk, Eva M. Strijbis, Jeroen Geurts, Ping Zhang, Chang-Chun Ling, V. Wee Yong   +16 more
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Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy

Molecules, 2022
We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan substrates versican and biglycan in an ocular microenvironment of proliferative diabetic ...
Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Eef Allegaert, Mohammad Mairaj Siddiquei, Ajmal Ahmad, Priscilla Gikandi, Gert De Hertogh, Ghislain Opdenakker   +7 more
doaj   +1 more source

Versican expression in murine fibroblasts.

, 2015
(A) Western blot of recombinant versican expression in the cell lysate and conditioned medium of versican-transfected fibroblasts, suggesting the recombinant protein is synthesized and secreted.
Bruce M. McManus (351410), Darryl Knight (217282), Anna J. Meredith (770418), Zongshu Luo (351408), Jon M. Carthy (351406), Seti Boroomand (752467), Thomas Abraham (121104)   +6 more
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Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma

Frontiers in Oncology, 2019
Versican and tumor-associated macrophages (TAMs) are involved in growth and metastases in several cancers. Here, we investigated the potential role of versican, a matrix proteoglycan, and its correlation with TAMs infiltrates in different stages of two ...
Diego Carlos dos Reis, Diego Carlos dos Reis, Karine Araújo Damasceno, Cecília Bonolo de Campos, Emerson Soares Veloso, Gabriela Rafaela Arantes Pêgas, Lucas Rocha Kraemer, Michele Angela Rodrigues, Matheus Silvério Mattos, Dawidson Assis Gomes, Paula Peixoto Campos, Enio Ferreira, Remo Castro Russo, Geovanni Dantas Cassali   +13 more
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Versican increases N-cadherin expression.

, 2015
(A) Light microscopy shows no major change in cell morphology in versican-transfected fibroblasts at both sub-confluent and confluent densities. (B) Representative Western blot showing increased expression of N-cadherin in versican-transfected cells. (C)
Bruce M. McManus (351410), Darryl Knight (217282), Anna J. Meredith (770418), Zongshu Luo (351408), Jon M. Carthy (351406), Seti Boroomand (752467), Thomas Abraham (121104)   +6 more
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