Results 21 to 30 of about 10,151 (207)

Differential Expression of Versican Isoforms in Brain Tumors [PDF]

Journal of Neuropathology and Experimental Neurology, 1996
Versican is a member of the family of large aggregating chondroitin sulfate proteoglycans which are one of the major constituents of brain extracellular matrix (ECM). We examined the expression of versican splice variants at mRNA and protein levels in normal human brain and in gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas.
Paulus W, Baur I, Dours-Zimmermann MT, Zimmermann DR   +3 more
openaire   +4 more sources

Versican expression from lung fibroblasts suppresses pulmonary fibrosis

Nature Communications
The activation and accumulation of lung fibroblasts, leading to excessive ECM deposition, is a pathogenic hallmark of Idiopathic Pulmonary Fibrosis, a lethal and currently untreatable disease.
Paraskevi Kanellopoulou, Ilianna Barbayianni, Dionysios Fanidis, Martina Samiotaki, Eleni Katsiouli, Dimitris Nastos, Stefanos Smyrniotis, Maria Shira, Apostolos Galaris, Vagelis Rinotas, Sofia Grammenoudi, Christiana Magkrioti, Ioannis Tomos, Africa Martinez Blanco, Ioanna Tremi, Ioannis Vamvakaris, Nuria Gavara, Sophia Havaki, Vassilis Gorgoulis, Hideto Watanabe, Vassilis Aidinis   +20 more
doaj   +2 more sources

Knockin expression of human ADAMTS5 impairs cardiovascular development and aggravates cerebral cavernous malformations in mice [PDF]

Disease Models & Mechanisms
Xi Yang, Jieying Zhang, Zifeng Dai, Tianzi Yang, Liya Xie, Fei Gao, Xiangjian Zheng, Zhiming Han   +7 more
doaj   +2 more sources

Versican Degradation and Vascular Disease [PDF]

Trends in Cardiovascular Medicine, 2006
Versican is an abundant proteoglycan in the blood vessel wall that is increased after vascular injury and accumulates in advanced atherosclerotic plaques. Versican is a large molecule with domains that mediate binding to cytokines, enzymes, lipoproteins, other extracellular matrix molecules, and signaling receptors.
Richard D, Kenagy, Anna H, Plaas, Thomas N, Wight   +2 more
openaire   +2 more sources

Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages. [PDF]

PLoS ONE, 2015
Hypoxia is a hallmark of many pathological tissues. Macrophages accumulate in hypoxic sites and up-regulate a range of hypoxia-inducible genes. The matrix proteoglycan versican has been identified as one such gene, but the mechanisms responsible for ...
Fattah Sotoodehnejadnematalahi, Karl J Staples, Elvina Chrysanthou, Helen Pearson, Loems Ziegler-Heitbrock, Bernard Burke   +5 more
doaj   +1 more source

Gene Expression and Immunochemistry Analysis of ADAMTS-1 and Versican in Ameloblastoma

International Journal of Dentistry, 2022
Background. Ameloblastoma is a benign but locally invasive odontogenic epithelial tumor, associated with a high recurrence rate after treatment. The action of enzymes of the metalloproteinase family is important to the degraded extracellular matrix ...
Osvaldo Rodrigues de Souza Neto, Hellen Thais Fuzii, Suély Vieira Da Silva, Vanessa Morais Freitas, João de Jesus Viana Pinheiro   +4 more
doaj   +1 more source

Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer

Frontiers in Oncology, 2021
A growing body of literature links events associated with the progression and severity of immunity and inflammatory disease with the composition of the tissue extracellular matrix as defined by the matrisome.
Priyanka Hirani, Valentine Gauthier, Carys E. Allen, Thomas N. Wight, Oliver M. T. Pearce   +4 more
doaj   +1 more source

Role of versican in malignant pleural mesothelioma

, 2021
Versican promotes experimental tumor growth through cell- and non cell-autonomous mechanisms. Its role in mesothelioma progression has not been investigated so far.
Παππάς, Απόστολος, Pappas, Apostolos   +1 more
core   +1 more source

The biochemistry and immunohistochemistry of versican [PDF]

, 2018
Versican is a chondroitin sulfate proteoglycan found in the extracellular matrix that is important for changes in cell phenotype associated with development and disease. Versican has been shown to be involved in cardiovascular disorders, as well as lung disease and fibrosis, inflammatory bowel disease, cancer, and several other diseases that have an ...
Stephen P, Evanko, Christina K, Chan, Pamela Y, Johnson, Charles W, Frevert, Thomas N, Wight   +4 more
openaire   +2 more sources

TGF-β1 Promotes Osteosarcoma Cell Migration and Invasion Through the miR-143-Versican Pathway

Cellular Physiology and Biochemistry, 2014
Background & Aims: TGF-β1 is an abundant cytokine present in the tumour microenvironment. It has been shown to trigger versican expression in human osteosarcoma cells, which may account for the metastatic potential of these cells.
Fengfeng Li, Shaohua Li, Tao Cheng
doaj   +1 more source