Results 21 to 30 of about 8,199 (176)
Journal of Family Medicine and Primary Care, 2023 Objective: Versican is a chondroitin sulphate proteoglycan with raised expression at site of inflammation, and uterine fibroids are associated with local inflammation. Hence, this study aimed to estimate serum Versican levels in pre-menopausal women with
Pratima Jasti +3 more
doaj +1 more source
Increased renal versican expression is associated with progression of chronic kidney disease. [PDF]
PLoS ONE, 2012 Novel prognostic markers for progression of kidney disease are needed to distinguish patients who might benefit from a more aggressive nephroprotective therapy.
Michael Rudnicki +12 more
doaj +1 more source
Isolation and Purification of Versican and Analysis of Versican Proteolysis [PDF]
, 2014 Versican is a widely distributed chondroitin sulfate proteoglycan that forms large complexes with the glycosaminoglycan hyaluronan (HA). As a consequence of HA binding to its receptor CD44 and interactions of the versican C-terminal globular (G3) domain with a variety of extracellular matrix proteins, versican is a key component of well-defined ...
Day, A.J.; id_orcid 0000-0002-1415-3134 +2 more
openaire +4 more sources
Versican and Versican-matrikines in Cancer Progression, Inflammation, and Immunity
Journal of Histochemistry & Cytochemistry, 2020 Versican is an extracellular matrix proteoglycan with key roles in multiple facets of cancer development, ranging from proliferative signaling, evasion of growth-suppressor pathways, regulation of cell death, promotion of neoangiogenesis, and tissue invasion and metastasis.
Athanasios, Papadas +4 more
openaire +3 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on VCAN (versican), with data on DNA, on the protein encoded, and where the gene is implicated.
Hernández, D, Docampo, MJ, Bassols, A
openaire +2 more sources
Versican: A Dynamic Regulator of the Extracellular Matrix [PDF]
Journal of Histochemistry & Cytochemistry, 2020 Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan belonging to the aggrecan/lectican family. In adults, this proteoglycan serves as a structural macromolecule of the extracellular matrix in the brain and large blood vessels. In contrast, versican is transiently expressed at high levels during development and under pathological ...
Shamima, Islam, Hideto, Watanabe
openaire +2 more sources
Gene Expression and Immunochemistry Analysis of ADAMTS-1 and Versican in Ameloblastoma
International Journal of Dentistry, 2022 Background. Ameloblastoma is a benign but locally invasive odontogenic epithelial tumor, associated with a high recurrence rate after treatment. The action of enzymes of the metalloproteinase family is important to the degraded extracellular matrix ...
Osvaldo Rodrigues de Souza Neto +4 more
doaj +1 more source
Versican Degradation and Vascular Disease [PDF]
Trends in Cardiovascular Medicine, 2006 Versican is an abundant proteoglycan in the blood vessel wall that is increased after vascular injury and accumulates in advanced atherosclerotic plaques. Versican is a large molecule with domains that mediate binding to cytokines, enzymes, lipoproteins, other extracellular matrix molecules, and signaling receptors.
Richard D, Kenagy +2 more
openaire +2 more sources
Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages. [PDF]
PLoS ONE, 2015 Hypoxia is a hallmark of many pathological tissues. Macrophages accumulate in hypoxic sites and up-regulate a range of hypoxia-inducible genes. The matrix proteoglycan versican has been identified as one such gene, but the mechanisms responsible for ...
Fattah Sotoodehnejadnematalahi +5 more
doaj +1 more source
Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer
Frontiers in Oncology, 2021 A growing body of literature links events associated with the progression and severity of immunity and inflammatory disease with the composition of the tissue extracellular matrix as defined by the matrisome.
Priyanka Hirani +4 more
doaj +1 more source