Results 31 to 40 of about 10,151 (207)
Versican and the control of inflammation
Matrix Biology, 2014 Versican is an extracellular matrix (ECM) proteoglycan that interacts with cells by binding to non-integrin and integrin receptors and to other ECM components that associate with the cell surface. Recent studies have shown also that versican interacts with myeloid and lymphoid cells promoting their adhesion and production of inflammatory cytokines ...
Wight, Thomas N. +2 more
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Versican and the regulation of cell phenotype in disease [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014 Versican is an extracellular matrix (ECM) proteoglycan that is present in the pericellular environment of most tissues and increases in many different diseases. Versican interacts with cells to influence the ability of cells to proliferate, migrate, adhere and assemble an ECM.The structure of the versican molecule is briefly reviewed and studies ...
Thomas N, Wight +4 more
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Versican: A Dynamic Regulator of the Extracellular Matrix [PDF]
Journal of Histochemistry & Cytochemistry, 2020 Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan belonging to the aggrecan/lectican family. In adults, this proteoglycan serves as a structural macromolecule of the extracellular matrix in the brain and large blood vessels. In contrast, versican is transiently expressed at high levels during development and under pathological ...
Shamima, Islam, Hideto, Watanabe
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Cell Reports, 2020 Summary: Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obesity.
Chang Yeop Han +15 more
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The Versican Gene and the Risk of Intracranial Aneurysms [PDF]
Stroke, 2006 Background and Purpose— The proteoglycan versican is an excellent candidate gene for intracranial aneurysms (IAs) because it plays an important role in extracellular matrix assembly and is localized in a previously implicated locus for IAs on chromosome 5q.
Ynte M, Ruigrok +2 more
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Versican: a novel modulator of hepatic fibrosis [PDF]
Laboratory Investigation, 2016 Little is known about the deposition and turnover of proteoglycans in liver fibrosis, despite their abundance in the extracellular matrix. Versican plays diverse roles in modulating cell behavior in other fibroproliferative diseases, but remains poorly described in the liver.
Terence N, Bukong +4 more
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Inhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells. [PDF]
PLoS ONE, 2012 Hyaluronan (HA) is a major component of the extracellular matrix (ECM) and is synthesized by three HA synthases (HAS). Similarities between the HAS2 knockout mouse and the hdf mutant mouse, which has a mutation in the versican gene, suggest that HA and ...
Kate E Keller +4 more
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Role of Versican in the Pathogenesis of Peritoneal Endometriosis [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2016 Context: Sampson’s theory cannot explain why only some cycling women develop peritoneal endometriosis. Few studies have focused on the pelvic peritoneum, which receives regurgitated endometrial tissues. We hypothesized that molecular alterations in the peritoneum are involved in the development of peritoneal ...
Hirohiko, Tani +7 more
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Versican Mediates Mesenchymal-Epithelial Transition [PDF]
Molecular Biology of the Cell, 2006 Versican is a large extracellular chondroitin sulfate proteoglycan that belongs to the family of lecticans. Alternative splicing of versican generates at least four isoforms named V0, V1, V2, and V3. We show here that ectopic expression of versican V1 isoform induced mesenchymal-epithelial transition (MET) in NIH3T3 fibroblasts, and inhibition of ...
Wang, Sheng +7 more
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Molecules, 2023 Versican is a chondroitin sulfate proteoglycan (CSPG), which deposits in perineurium as a physical barrier and prevents the growth of axons out of the fascial boundary.
Chiung-Hui Liu +8 more
doaj +1 more source