Results 31 to 40 of about 8,199 (176)
Immunohistochemical and biochemical assay of versican in human sound predentine/dentine matrix
European Journal of Histochemistry, 2009 Aim of this study was to investigate the distribution of versican proteoglycan within the human dentine organic matrix by means of a correlative immunohistochemical analysis with field emission in-lens scanning electron microscope (FEI-SEM), transmission
A. Ruggeri +9 more
doaj +3 more sources
Versican and the regulation of cell phenotype in disease [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014 Versican is an extracellular matrix (ECM) proteoglycan that is present in the pericellular environment of most tissues and increases in many different diseases. Versican interacts with cells to influence the ability of cells to proliferate, migrate, adhere and assemble an ECM.The structure of the versican molecule is briefly reviewed and studies ...
Thomas N, Wight +4 more
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TGF-β1 Promotes Osteosarcoma Cell Migration and Invasion Through the miR-143-Versican Pathway
Cellular Physiology and Biochemistry, 2014 Background & Aims: TGF-β1 is an abundant cytokine present in the tumour microenvironment. It has been shown to trigger versican expression in human osteosarcoma cells, which may account for the metastatic potential of these cells.
Fengfeng Li, Shaohua Li, Tao Cheng
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The biochemistry and immunohistochemistry of versican [PDF]
, 2018 Versican is a chondroitin sulfate proteoglycan found in the extracellular matrix that is important for changes in cell phenotype associated with development and disease. Versican has been shown to be involved in cardiovascular disorders, as well as lung disease and fibrosis, inflammatory bowel disease, cancer, and several other diseases that have an ...
Stephen P, Evanko +4 more
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Inflammation Amplification by Versican: The First Mediator [PDF]
International Journal of Molecular Sciences, 2012 The effects of inflammation may not always benefit the individual. Its amplifying nature represents a highly regulated biological program, and the inflammatory microenvironment is its essential component. Growing evidence suggests that the ECM (extracellular matrix) is important for the early steps of inflammation.
Zhang, Zhenwei +2 more
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Cell Reports, 2020 Summary: Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obesity.
Chang Yeop Han +15 more
doaj +1 more source
Versican and the control of inflammation
Matrix Biology, 2014 Versican is an extracellular matrix (ECM) proteoglycan that interacts with cells by binding to non-integrin and integrin receptors and to other ECM components that associate with the cell surface. Recent studies have shown also that versican interacts with myeloid and lymphoid cells promoting their adhesion and production of inflammatory cytokines ...
Wight, Thomas N. +2 more
openaire +2 more sources
Inhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells. [PDF]
PLoS ONE, 2012 Hyaluronan (HA) is a major component of the extracellular matrix (ECM) and is synthesized by three HA synthases (HAS). Similarities between the HAS2 knockout mouse and the hdf mutant mouse, which has a mutation in the versican gene, suggest that HA and ...
Kate E Keller +4 more
doaj +1 more source
Molecules, 2023 Versican is a chondroitin sulfate proteoglycan (CSPG), which deposits in perineurium as a physical barrier and prevents the growth of axons out of the fascial boundary.
Chiung-Hui Liu +8 more
doaj +1 more source
The Versican Gene and the Risk of Intracranial Aneurysms [PDF]
Stroke, 2006 Background and Purpose— The proteoglycan versican is an excellent candidate gene for intracranial aneurysms (IAs) because it plays an important role in extracellular matrix assembly and is localized in a previously implicated locus for IAs on chromosome 5q.
Ynte M, Ruigrok +2 more
openaire +2 more sources