Results 51 to 60 of about 8,199 (176)

Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma

Frontiers in Oncology, 2019
Versican and tumor-associated macrophages (TAMs) are involved in growth and metastases in several cancers. Here, we investigated the potential role of versican, a matrix proteoglycan, and its correlation with TAMs infiltrates in different stages of two ...
Diego Carlos dos Reis, Diego Carlos dos Reis, Karine Araújo Damasceno, Cecília Bonolo de Campos, Emerson Soares Veloso, Gabriela Rafaela Arantes Pêgas, Lucas Rocha Kraemer, Michele Angela Rodrigues, Matheus Silvério Mattos, Dawidson Assis Gomes, Paula Peixoto Campos, Enio Ferreira, Remo Castro Russo, Geovanni Dantas Cassali   +13 more
doaj   +1 more source

Immunoregulatory roles of versican proteolysis in the myeloma microenvironment [PDF]

Blood, 2016
Key Points Interplay between myeloma niche stromal cells and myeloid cells generates versikine, a novel damage-associated molecular pattern. Versikine may promote antigen-presenting cell maturation and CD8+ T-cell activation/recruitment to the tumor bed.
Chelsea, Hope, Simon, Foulcer, Justin, Jagodinsky, Sarah X, Chen, Jeffrey L, Jensen, Sanjay, Patel, Catherine, Leith, Ioanna, Maroulakou, Natalie, Callander, Shigeki, Miyamoto, Peiman, Hematti, Suneel S, Apte, Fotis, Asimakopoulos   +12 more
openaire   +5 more sources

Context-dependent bioactivity of versican fragments

Glycobiology, 2019
AbstractVersican (VCAN) proteolysis and the accumulation of VCAN fragments occur in many developmental and disease processes, affecting extracellular matrix (ECM) structure and cell phenotype. Little is known about the significance of proteolysis and the roles of fragments, or how this ECM remodeling affects the microenvironment and phenotype of ...
Katherine Payne, Timms, Sean Bertram, Maurice   +1 more
openaire   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Versican expression in canine carcinomas in benign mixed tumours: is there an association with clinical pathological factors, invasion and overall survival?

BMC Veterinary Research, 2012
Background Components of the extracellular matrix have been studied in an attempt to elucidate the mechanisms involved in the biological behaviour of tumours.
Damasceno Karine A, Bertagnolli Angélica C, Estrela-Lima Alessandra, Ribeiro Lorena GR, Rabelo Bruna S, Campos Cecília B, Barros André LB, Cassali Geovanni D   +7 more
doaj   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Histopathologic Analysis of the Morpho‐Functional Zones of the Human Acetabular Labrum

Clinical Anatomy, EarlyView.
ABSTRACT The structural and functional adaptation of soft tissues to mechanical load controls their ability to withstand injury and influences their capacity for healing. Similar to the knee meniscus, the acetabular labrum exhibits zonal differences in mechanical load distribution, resulting in distinct regions with unique structural and functional ...
Abdulaziz A. Alomiery, Andrew C. Hall, Thomas H. Gillingwater, Afaf Alsolami, Abduelmenem Alashkham   +4 more
wiley   +1 more source

Prognostic significance of Versican expression in gastric adenocarcinoma [PDF]

Oncogenesis, 2015
AbstractGastric cancer (GC) is the leading malignancy in the digestive system. Versican is a ubiquitous component of the extracellular matrix and has a role in tumor progression. We aim to examine the expression of Versican in GC and the relationship between Versican levels and patient survival.
Shen, X-H, Lin, W-R, Xu, M-D, Qi, P, Dong, L, Zhang, Q-Y, Ni, S-J, Weng, W-W, Tan, C, Huang, D, Ma, Y-Q, Zhang, W, Sheng, W-Q, Wang, Y-Q, Du, X   +14 more
openaire   +2 more sources