Results 61 to 70 of about 10,151 (207)

Versican expression in canine carcinomas in benign mixed tumours: is there an association with clinical pathological factors, invasion and overall survival?

BMC Veterinary Research, 2012
Background Components of the extracellular matrix have been studied in an attempt to elucidate the mechanisms involved in the biological behaviour of tumours.
Damasceno Karine A, Bertagnolli Angélica C, Estrela-Lima Alessandra, Ribeiro Lorena GR, Rabelo Bruna S, Campos Cecília B, Barros André LB, Cassali Geovanni D   +7 more
doaj   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Versican alters the function of fibroblasts.

, 2015
(A) Versican increased cell proliferation 1.44 ± 0.07 fold over control cells ...
Bruce M. McManus (351410), Darryl Knight (217282), Anna J. Meredith (770418), Zongshu Luo (351408), Jon M. Carthy (351406), Seti Boroomand (752467), Thomas Abraham (121104)   +6 more
core   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, EarlyView.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Ο ρόλος του versican στο μεσοθηλίωμα υπεζωκότα

, 2021
Η πρωτεΐνη versican προάγει την καρκινική αύξηση σε πειραματικά μοντέλα μέσω αυτοκρινών και παρακρινών μηχανισμών. Ο ρόλος της στην πρόοδο του μεσοθηλιώματος δεν έχει μέχρι τώρα ερευνηθεί.
Παππάς Απόστολος, Pappas Apostolos   +1 more
core  

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Prognostic significance of Versican expression in gastric adenocarcinoma [PDF]

Oncogenesis, 2015
AbstractGastric cancer (GC) is the leading malignancy in the digestive system. Versican is a ubiquitous component of the extracellular matrix and has a role in tumor progression. We aim to examine the expression of Versican in GC and the relationship between Versican levels and patient survival.
Shen, X-H, Lin, W-R, Xu, M-D, Qi, P, Dong, L, Zhang, Q-Y, Ni, S-J, Weng, W-W, Tan, C, Huang, D, Ma, Y-Q, Zhang, W, Sheng, W-Q, Wang, Y-Q, Du, X   +14 more
openaire   +2 more sources

Structure, Function and Regulation of Versican: The Most Abundant Type of Proteoglycan in the Extracellular Matrix

Acta Medica Iranica, 2013
One of the main members of the large aggregating proteoglycans (PGs) family is versican which is able to bind to hyaluronate. Versican is a chondroitin sulfate proteoglycan and is a key ingredient of the extracellular matrix.
Fattah Sotoodehnejadnematalahi, Bernard Burke   +1 more
doaj  

The Astrocyte Clock Controls Circadian Perineuronal Net Remodeling, Synapse Strength and Learning Behavior

Glia, Volume 74, Issue 10, October 2026.
Bmal1 regulates astrocyte extracellular matrix (ECM) gene expression. Bmal1 deletion in astrocytes disrupts normal circadian rhythms in perineuronal nets (PNN) and reduces PNN content in the hippocampus. In parallel with loss of PNNs, deletion of the core circadian clock gene Bmal1 in astrocytes alters behavior and synaptic function in vivo.
Philip C. Smith, Elsa I. Quillin, Katheryn B. Lefton, Celia A. McKee, Brendan Dang, Thomas Papouin, Erik S. Musiek   +6 more
wiley   +1 more source