Results 61 to 70 of about 15,922 (221)
Versican: A Dynamic Regulator of the Extracellular Matrix [PDF]
Journal of Histochemistry & Cytochemistry, 2020 Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan belonging to the aggrecan/lectican family. In adults, this proteoglycan serves as a structural macromolecule of the extracellular matrix in the brain and large blood vessels. In contrast, versican is transiently expressed at high levels during development and under pathological ...
Shamima, Islam, Hideto, Watanabe
openaire +2 more sources
Expression of a novel versican variant in dorsal root ganglia from spared nerve injury rats [PDF]
, 2019 The size and modular structure of versican and its gene suggest the existence of multiple splice variants. We have identified, cloned, and sequenced a previously unknown exon located within the noncoding gene sequence downstream of exon 8.
Alvarez, Pedro +6 more
core +1 more source
Histopathologic Analysis of the Morpho‐Functional Zones of the Human Acetabular Labrum
Clinical Anatomy, EarlyView.ABSTRACT The structural and functional adaptation of soft tissues to mechanical load controls their ability to withstand injury and influences their capacity for healing. Similar to the knee meniscus, the acetabular labrum exhibits zonal differences in mechanical load distribution, resulting in distinct regions with unique structural and functional ...
Abdulaziz A. Alomiery +4 more
wiley +1 more source
The FEBS Journal, EarlyView.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
Platelet-derived growth factor-stimulated versican synthesis but not glycosaminoglycan elongation in vascular smooth muscle is mediated via Akt phosphorylation [PDF]
, 2014 Proteoglycans are associated with the initiation of atherosclerosis due to their binding of apolipoproteins on lipid particles leading to retention in the vessel wall.
Getachew, R +6 more
core +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Versican contributes to ligament formation of knee joints
PLOS ONE, 2021 Versican is a large proteoglycan in the extracellular matrix. During embryonic stages, it plays a crucial role in the development of cartilage, heart, and dermis. Previously, we reported thatPrx1-Vcanconditional knockout mice, lacking Vcan expression in mesenchymal condensation areas of the limb bud, show the impaired joint formation and delayed ...
Tomoko Higuchi +7 more
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Distribution of versican and hyaluronan in the mouse uterus during decidualization
Brazilian Journal of Medical and Biological Research, 2003 Preparation for embryo implantation requires extensive adaptation of the uterine microenvironment. This process consists of cell proliferation and cell differentiation resulting in the transformation of endometrial fibroblasts into a new type of cell ...
S. San Martin +2 more
doaj +1 more source
マイクロアレイ解析によって同定された胃原発消化管間質腫瘍の有用な予後因子VersicanとCD9 [PDF]
, 2011 浜松医科大学学位論文 医博第587号 ...
7471, 瀬戸口, 智彦
core +2 more sources
The FEBS Journal, EarlyView.Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki +4 more
wiley +1 more source