Results 81 to 90 of about 8,199 (176)

Sensing and Communicating β‐Cell Stress in the Context of T1D Etiology: New Opportunities for Therapeutic Impact

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Type 1 diabetes (T1D) results from the immune‐mediated destruction of insulin‐producing pancreatic β‐cells. Recent human studies show that early β‐cell stress maladaptations precede overt immune cell infiltration. DOC2B, a vesicle secretion regulatory protein that supports β‐cell functionality and resilience against stress, declines early in T1D ...
Diana Esparza, Chathurani S. Jayasena, Tijana Jovanovic‐Talisman, Debbie C. Thurmond   +3 more
wiley   +1 more source

The role of versican G3 domain in regulating breast cancer cell motility including effects on osteoblast cell growth and differentiation in vitro – evaluation towards understanding breast cancer cell bone metastasis

BMC Cancer, 2012
Background Versican is detected in the interstitial tissues at the invasive margins of breast carcinoma, is predictive of relapse, and negatively impacts overall survival rates.
Du William, Fang Ling, Yang Weining, Sheng Wang, Zhang Yaou, Seth Arun, Yang Burton B, Yee Albert J   +7 more
doaj   +1 more source

Loss of Brain‐Derived Estrogen Is Associated With Sex‐ and Age‐Dependent Alterations in Memory, Affective Behavior, and Hippocampal Extracellular Matrix Gene Expression

Aging Cell, Volume 25, Issue 6, June 2026.
Age, sex, and estrogen loss are widely recognized risk factors for Alzheimer's disease. Here, we show that brain‐specific aromatase knockout (bArKO) and the resulting estrogen loss lead to memory impairment, reduced social interaction, and extracellular environment dysregulation selectively in aged female mice, but not in young female or male mice ...
Natalie C. Piehl, Ariel W. Halle, Guadalupe Rodriguez, Andrea Locci, Stacy Kujawa, Caroline Haywood, John Coon V, Ross P. McNally, Zaina A. Karim, Tianming You, Hongxin Dong, Serdar E. Bulun, Hong Zhao   +12 more
wiley   +1 more source

Hyaluronan and versican in the kidney in obesity

The FASEB Journal, 2006
Hyaluronan in the kidney is located in the outer and inner medulla with the majority found near the papilla tip. Hyaluronan accumulates in the inner medulla in obesity. However, the distribution of hyaluronan in the inner medulla is not known. Versican is a hyaluronan binding protein but the amount in the inner medulla in lean kidneys or in obesity is ...
Jeff Henegar, Jessica Pongetti
openaire   +1 more source

Regeneration of an Extracellular Matrix Ecosystem Following Subcutaneous Injection With Different Radiesse Dilutions: A Histologic and Ultrasound Study

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Calcium hydroxylapatite‐carboxymethylcellulose (CaHA‐CMC) stimulates neocollagenesis across a range of dilutions; however, the magnitude and temporal profile of this bioregenerative response have not yet been comprehensively examined.
Kate Goldie, Gabriela Casabona, Niamh Corduff, Alec D. McCarthy, Kristina Riegel   +4 more
wiley   +1 more source

Glucocorticoids influence versican and chondroitin sulphate proteoglycan levels in the fetal sheep lung

Respiratory Research, 2018
Background Prenatal glucocorticoid treatment decreases alveolar tissue volumes and facilitates fetal lung maturation, however the mechanisms responsible are largely unknown. This study examines whether changes in versican levels or sulphation patterns of
Annie R. A. McDougall, Amanda J. Fosang, Jessica Faggian, Megan J. Wallace, Kelly J. Crossley, Timothy J. Cole, Stuart B. Hooper   +6 more
doaj   +1 more source

Mechanistic Review of Topical Therapies Targeting Dermal Fibroblasts in Skin Aging and Rejuvenation

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Skin aging appears in multiple forms, including wrinkles, sagging, scarring, atrophy, and photoaging. Although each phenotype has distinct biological features, all are rooted in dermal fibroblast dysfunction. This review examines the molecular pathways underlying these conditions and evaluates topical interventions designed to ...
Seyedeh Melika Akaberi, Mohammad Esfandiyari, Hamid Reza Ahmadi Ashtiani   +2 more
wiley   +1 more source

Effects of Versican V0/V1 gene silencing on biological behaviors of mouse dental papilla cells [PDF]

Kouqiang yixue
Objective To investigate the effect of Versican V0/V1 on biological behaviors of mouse dental papilla cells (mDPCs). Methods mDPCs were isolated from C57BL/6J mice at embryonic day 16.5 (E16.5).
WU Jiayan, HUANG Haiyan, SONG Chenyu, JIANG Beizhan
doaj   +1 more source

Associations of Adipocyte-derived Versican and Macrophage-derived Biglycan with Body Adipose Tissue and Hepatosteatosis in Obese Children

JCRPE
INTRODUCTION: In animal models of obesity, adipocyte-derived versican, and macrophage-derived biglycan play a crucial role in mediating adipose tissue inflammation.
Reyhan Deveci Sevim, Mustafa Gök, Özge Çevik, Ömer Erdoğan, Sebla Güneş, Tolga Ünüvar, Ahmet Anık   +6 more
doaj   +1 more source

Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding.

PLoS ONE, 2014
BackgroundWe hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to stress-induced ECM-reorganization in ...
Maria Vistnes, Jan Magnus Aronsen, Ida G Lunde, Ivar Sjaastad, Cathrine R Carlson, Geir Christensen   +5 more
doaj   +1 more source