Results 81 to 90 of about 10,151 (207)

Optimal stimulation toward the dermal papilla lineage can be promoted by combined use of osteogenic and adipogenic inducers

FEBS Open Bio, 2020
Dermal papilla cells (DPCs) play crucial roles in hair regeneration, but they readily lose their hair‐forming ability during in vitro culture. Although the formation of spheroids partially restores the ability, shrinkage of the spheroids makes it ...
Taheruzzaman Kazi, Ichitaro Niibe, Akio Nishikawa, Takashi Matsuzaki   +3 more
doaj   +1 more source

Lumican and versican protein expression are associated with colorectal adenoma-to-carcinoma progression. [PDF]

PLoS ONE, 2017
One prominent event associated with colorectal adenoma-to-carcinoma progression is genomic instability. Approximately 85% of colorectal cancer cases exhibit chromosomal instability characterized by accumulation of chromosome copy number aberrations (CNAs)
Meike de Wit, Beatriz Carvalho, Pien M Delis-van Diemen, Carolien van Alphen, Jeroen A M Beliën, Gerrit A Meijer, Remond J A Fijneman   +6 more
doaj   +1 more source

Microenvironment‐Responsive Drug Delivery Systems for Ocular Surface Diseases: Mechanisms, Applications, and Translational Challenges

Small Science, Volume 6, Issue 8, August 2026.
Microenvironment‐responsive drug delivery systems overcome ocular physiological barriers by responding to temperature, pH, ions, reactive oxygen species, and enzymes. This review bridges material design, performance evaluation, and clinical translation, offering actionable insights for treating dry eye disease, infectious keratitis, and corneal ...
Jiamin Liu, Liangbo Chen, Yao Fu, Siyi Zhang   +3 more
wiley   +1 more source

Sputum Hyaluronan and Versican in Severe Eosinophilic Asthma [PDF]

International Archives of Allergy and Immunology, 2012
<b><i>Background:</i></b> We examined levels of hyaluronan, a matrix glycosaminoglycan and versican, a matrix proteoglycan, in the sputum of asthmatics treated with mepolizumab (anti-IL-5 monoclonal antibody) versus placebo to evaluate the utility of these measurements as possible biomarkers of asthma control and airway ...
Andrew G, Ayars, Leonard C, Altman, Sue, Potter-Perigo, Katherine, Radford, Thomas N, Wight, Parameswaran, Nair   +5 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, Volume 20, Issue 7, Page 1780-1799, July 2026.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Hyaluronate binding properties of versican.

Journal of Biological Chemistry, 1992
We have previously cloned a large chondroitin sulfate proteoglycan (versican) from human fibroblasts. The primary sequence shows that the N terminus contains sequence homology with known hyaluronate-binding molecule, suggesting that versican can bind hyaluronate.
R G, LeBaron, D R, Zimmermann, E, Ruoslahti   +2 more
openaire   +2 more sources

Distribution of versican and hyaluronan in the mouse uterus during decidualization

Brazilian Journal of Medical and Biological Research, 2003
Preparation for embryo implantation requires extensive adaptation of the uterine microenvironment. This process consists of cell proliferation and cell differentiation resulting in the transformation of endometrial fibroblasts into a new type of cell ...
S. San Martin, M. Soto-Suazo, T.M.T. Zorn   +2 more
doaj   +1 more source

Versican accumulates in vascular lesions in pulmonary arterial hypertension

, 2016
Pulmonary arterial hypertension (PAH) is a lethal condition for which there is no effective curative pharmacotherapy. PAH is characterized by vasoconstriction, wall thickening of pulmonary arteries, and increased vascular resistance.
Chan, Christina K., Inger Eriksson, Cao, Xiaofang, Ya‐Ting Chang, Tran-Lundmark, Karin,, Xiaofang Cao, Andersson-Sjöland, Annika, Kjellen, Lena,, Kjellén, Lena, Andersson-Sjoland, Annika,, Pamela Y. Johnson, Johansson, Staffan,, Gunilla Westergren‐Thorsson, Johnson, Pamela Y., Ulf Hedin, Karin Tran‐Lundmark, Cao, Xiaofang,, Wight, Thomas N., Westergren-Thorsson, Gunilla, Westöö, Christian, Tran-Lundmark, Karin, Johansson, Staffan, Lena Kjellén, Christian Westöö, Eriksson, Inger,, Annika Andersson‐Sjöland, Christina K. Chan, Thomas N. Wight, Hedin, Ulf,, Wight, Thomas N.,, Christian Norvik, Chang, Ya-Ting,, Chan, Christina K.,, Johnson, Pamela Y.,, Norvik, Christian, Hedin, Ulf, Chang, Ya Ting, Westoo, Christian,, Norvik, Christian,, Westergren-Thorsson, Gunilla,, Staffan Johansson, Eriksson, Inger   +41 more
core   +1 more source

Inhibition of the Metalloproteinase ADAMTS5 Suppresses Colorectal Cancer Metastasis via the PEDF/Wnt/β‐Catenin Pathway

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT At present, colorectal cancer (CRC) ranks as the third most prevalent cancer globally and is the second most common cause of mortality associated with cancer. The expression of A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 (ADAMTS5) is upregulated in CRC, and high ADAMTS5 expression strongly correlates with an unfavorable ...
Xuan Sun, Hanqing Zhang, Yan Hu, Shengyu Jiao, Zesheng Yao, Ke Yi, Guojian Gu, Xiaohui Xu   +7 more
wiley   +1 more source

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

Glia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat, Alima Ahmed, Mariano Viapiano, Preethi S. Ganapathy   +3 more
wiley   +1 more source