Results 91 to 100 of about 8,199 (176)

Homozygous Recessive Versican Missense Variation Is Associated With Early Teeth Loss in a Pakistani Family

open access: yesFrontiers in Genetics, 2019
Only a few genes involved in teeth development and morphology are known to be responsible for tooth abnormalities in Mendelian-inherited diseases. We studied an inbred family of Pakistani origin in which two first-cousin born brothers are affected by ...
Stefania Bigoni   +24 more
doaj   +1 more source

Deposition of insoluble elastin by pulmonary fibroblasts from patients with COPD is increased by treatment with versican siRNA

open access: yesInternational Journal of COPD, 2017
Lian Wu,1,2 Jing Zhang,3 Jie Ming Qu,4 Chun-xue Bai,3 Mervyn J Merrilees5 1Department of Community and Health Services, Unitec, 2Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand; 3Department of ...
Wu L   +4 more
doaj  

The extracellular matrix in multiple sclerosis: an update

open access: yesBrazilian Journal of Medical and Biological Research, 2001
Extracellular matrix (ECM) molecules play important roles in the pathobiology of the major human central nervous system (CNS) inflammatory/demyelinating disease multiple sclerosis (MS). This mini-review highlights some recent work on CNS endothelial cell
R.A. Sobel
doaj   +1 more source

Interleukin-11 Promotes the Progress of Gastric Carcinoma via Abnormally Expressed Versican

open access: yesInternational Journal of Biological Sciences, 2012
Versican, a ubiquitous component of the extracellular matrix (ECM), accumulates both in tumor stroma and cancer cells and is highly regulated by various cytokines.
Zhenwei Zhang, Jianpeng Zhang, Lei Miao, Ke Liu, Shengsheng Yang, Chuanyong Pan, Binghua Jiao
doaj  

Versican Expression during Synovial Joint Morphogenesis

open access: yesInternational Journal of Biological Sciences, 2007
The extracellular matrix (ECM) plays a critical role in governing cell behavior and phenotype during limb skeletogenesis. Chondroitin sulfate proteoglycans (Cspgs) are highly expressed in the ECM of precartilage mesenchymal condensations and are ...
John B. Shepard, Heidi A. Krug, Brooklynn A. LaFoon, Stanley Hoffman, Anthony A. Capehart
doaj  

ADAMTS5 Orchestrates Cell Lineage Specific Patterning and Extracellular Matrix Organization During Semilunar Valve Development

open access: yesJournal of Cardiovascular Development and Disease
Aortic valve (AV) disease affects about 5% of the aging population, with AV replacement as the only treatment option. Histopathology indicates that accumulation of extracellular matrix (ECM) proteoglycans correlates with dysfunctional AVs.
Loren E. Dupuis   +4 more
doaj   +1 more source

Versican、CTGF、TGFβ1在子宫内膜样腺癌及子宫内膜上皮内瘤变中的表达和意义

open access: yesZhongguo shiyan zhenduanxue, 2016
目的探讨多功能蛋白聚糖(Versican)、结缔组织生长因子(CTGF)、转化生长因子β1(TGFβ1)在子宫内膜样腺癌(EA)及子宫内膜上皮内瘤变(EIN)中的表达及三者相关性。方法采用免疫组织化学方法对76例EA和35例EIN中Versican、CTGF、TGFβ1的表达情况进行了分析,阐述其在EA及EIN中的表达特征及相互关系。结果在76例EA中Versican、CTGF、TGFβ1阳性表达率分别为75%,65.8%,69.7%,在35例EIN中阳性表达率分别为42.9%,37.1%,37.1 ...
汪锋   +6 more
doaj  

Association of versican turnover with all-cause mortality in patients on haemodialysis.

open access: yesPLoS ONE, 2014
ObjectiveCardiovascular diseases are among the most common causes of mortality in renal failure patients undergoing haemodialysis. A high turnover rate of the proteoglycan versican, represented by the increased presence of its fragmentation products in ...
Federica Genovese   +4 more
doaj   +1 more source

Versican V0/V1 Is Essential For The Proliferation Of Mdpcs

open access: yesInternational Dental Journal
Aim or purpose: To evaluate the effect of Versican V0/V1 isoforms on the proliferation of mouse dental papilla cells (mDPCs). Materials and methods: Immunofluorescence staining was performed to observe the expression of GAG-β, GAG-α and EdU.
Jiayan Wu, Beizhan Jiang
doaj   +1 more source

Influencia de componentes de la matriz extracelular en la agresividad y potencial invasor del cáncer cérvicouterino: ¿Qué hay de nuevo?

open access: yesRevista Chilena de Obstetricia y Ginecología, 2011
El cáncer cérvico uterino (CCU) es una patología de alta incidencia y mortalidad. La investigación hasta ahora se ha enfocado en estudiar su asociación con virus papiloma.
Paula Segura H, Leonor Moyano S
doaj  

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