Results 91 to 100 of about 10,151 (207)
VCAN is upregulated in the cervical cancer stroma and modulates macrophage polarization
Frontiers in OncologyThe extracellular matrix (ECM) is a major component of the tumor microenvironment (TME) and plays an important role in cervical cancer progression. Versican, encoded by the VCAN gene, is a member of the aggrecan/proteoglycan family and has been reported ...
Shijia Liu +7 more
doaj +1 more source
ADAMTS Metalloproteases Generate Active Versican Fragments that Regulate Interdigital Web Regression [PDF]
, 2009 SummaryWe show that combinatorial mouse alleles for the secreted metalloproteases Adamts5, Adamts20 (bt), and Adamts9 result in fully penetrant soft-tissue syndactyly.
Lindner, Volkhard +9 more
core +1 more source
Metalloproteinase cleavage of versican at the fibroblast cell surface
, 2010 Versican is a large aggregating proteoglycan expressed in the pericellular matrix of fibroblast cells. It is highly expressed during development and remodeling.
Maurice, Sean Bertram
core +1 more source
Hyaluronan (HA) Receptors: Discovery, Function & Pathology
Proteoglycan Research, Volume 4, Issue 3, July 2026.ABSTRACT Hyaluronan (HA) is typically a long polymer of the repeating disaccharide, glucuronic acid‐β‐(1‐3)‐N‐acetylglucosamine polymerized by β(1‐4) bonds, with no obvious active site for biological activity. However, this dynamic polymer is vital for life in all metazoans and has a diverse array of functional characteristics due to the proteins that ...
Abby E. Bopp +8 more
wiley +1 more source
Versican induction in intimal/medial vs. adventitial tissue.
, 2018 Induction of versican message and protein in floating intimal/medial and adventitial tissue.
Richard D. Kenagy (141441) +14 more
core +1 more source
Hyaluronan and versican in the kidney in obesity
The FASEB Journal, 2006 Hyaluronan in the kidney is located in the outer and inner medulla with the majority found near the papilla tip. Hyaluronan accumulates in the inner medulla in obesity. However, the distribution of hyaluronan in the inner medulla is not known. Versican is a hyaluronan binding protein but the amount in the inner medulla in lean kidneys or in obesity is ...
Jeff Henegar, Jessica Pongetti
openaire +1 more source
Respiratory Research, 2018 Background Prenatal glucocorticoid treatment decreases alveolar tissue volumes and facilitates fetal lung maturation, however the mechanisms responsible are largely unknown. This study examines whether changes in versican levels or sulphation patterns of
Annie R. A. McDougall +6 more
doaj +1 more source
JCRPEINTRODUCTION: In animal models of obesity, adipocyte-derived versican, and macrophage-derived biglycan play a crucial role in mediating adipose tissue inflammation.
Reyhan Deveci Sevim +6 more
doaj +1 more source
Effects of Versican V0/V1 gene silencing on biological behaviors of mouse dental papilla cells [PDF]
Kouqiang yixueObjective To investigate the effect of Versican V0/V1 on biological behaviors of mouse dental papilla cells (mDPCs). Methods mDPCs were isolated from C57BL/6J mice at embryonic day 16.5 (E16.5).
WU Jiayan, HUANG Haiyan, SONG Chenyu, JIANG Beizhan
doaj +1 more source
Expression of versican protein in vivo.
, 2012 Versican protein expression is induced in two rat models of glomerulonephritis (Adriamycin-induced glomerulonephritis (ADR) and Passive Heymann Nephritis (PHN)) compared to respective controls, Lewis and Ctrl.
Carlamaria Zoja (114447) +12 more
core +1 more source