Results 91 to 100 of about 15,922 (221)

Integrative Single‐Cell and Machine Learning Analysis Identifies an EMT‐Associated Prognostic Signature for Papillary Thyroid Cancer

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background Epithelial–mesenchymal transition (EMT) plays a critical role in tumor progression; however, the underlying molecular mechanisms of EMT in papillary thyroid carcinoma (PTC) remain incompletely understood. This study aimed to investigate EMT‐related mechanisms in PTC using an integrative approach combining single‐cell RNA sequencing ...
Tianfeng Xu, Ruonan Sun, Yujie Zhang, Xun Zheng   +3 more
wiley   +1 more source

Combined Chondroitinase and KLF7 Expression Reduce Net Retraction of Sensory and CST Axons from Sites of Spinal Injury [PDF]

, 2017
Axon regeneration in the central nervous system is limited both by inhibitory extracellular cues and by an intrinsically low capacity for axon growth in some CNS populations.
Blackmore, Murray G., Hess, Evan, Nienhaus, Christopher, Wang, Zimei, Winsor, Kristen N.   +4 more
core   +1 more source

Expression of invasion-related extracellular matrix molecules in human glioblastoma versus intracerebral lung adenocarcinoma metastasis [PDF]

, 2010
Tumor cell invasion into the surrounding brain tissue is mainly responsible for the failure of radical surgical resection, with tumor recurrence in the form of microdisseminated disease.
Bognár, L., Hanzély, Z., Hutóczki, G., Kenyeres, A., Klekner, A., Mikó, E., Petrás, M., Scholtz, B., Tóth, J., Varga, I., Zahuczky, G.   +10 more
core   +1 more source

Pathological Roles of Astrocytes in Traumatic Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu, Yuxiao Ma, Baofeng Wang, Yongtao Zheng, Jie Ren, Qingfang Sun, Liuguan Bian, Yuhao Sun   +7 more
wiley   +1 more source

The role of versican G3 domain in regulating breast cancer cell motility including effects on osteoblast cell growth and differentiation in vitro – evaluation towards understanding breast cancer cell bone metastasis

BMC Cancer, 2012
Background Versican is detected in the interstitial tissues at the invasive margins of breast carcinoma, is predictive of relapse, and negatively impacts overall survival rates.
Du William, Fang Ling, Yang Weining, Sheng Wang, Zhang Yaou, Seth Arun, Yang Burton B, Yee Albert J   +7 more
doaj   +1 more source

Aqueous Humor Outflow Structure and Function Imaging At the Bench and Bedside: A Review. [PDF]

, 2016
Anterior segment glaucoma clinical care and research has recently gained new focus because of novel imaging modalities and the advent of angle-based surgical treatments. Traditional investigation drawn to the trabecular meshwork now emphasizes the entire
Huang, Alex S, Mohindroo, Chirayu, Weinreb, Robert N   +2 more
core   +1 more source

Heart–Lung Interactions in Gas Exchange: From Physiology to Pathophysiology

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
This review outlines factors compromising the efficiency of alveolar gas exchange. Perturbation in lung fluid balance from capillary and alveolar sources is considered. Safety factors against edema formation are presented. A model is presented to describe gas diffusion limitation considering pulmonary fibrosis, lung resection, heart failure syndromes ...
Giuseppe Miserocchi, Egidio Beretta
wiley   +1 more source

Lung fibrotic tenascin-C upregulation is associated with other extracellular matrix proteins and induced by TGFβ1 [PDF]

, 2015
Background Idiopathic pulmonary fibrosis (IPF) is a progressive parenchymal lung disease of unknown aetiology and poor prognosis, characterized by altered tissue repair and fibrosis.
Dorca i Sargatal, Jordi, Escobar Campuzano, Ignacio, Estany, S., Llatjós, Roger, Manresa, Federico, Molina Molina, María, Montes Worboys, Ana, Penín, Rosa, Santos Pérez, Salud, Vicens Zygmunt, Vanesa, Xaubet Mir, Antonio   +10 more
core   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Glucocorticoids influence versican and chondroitin sulphate proteoglycan levels in the fetal sheep lung

Respiratory Research, 2018
Background Prenatal glucocorticoid treatment decreases alveolar tissue volumes and facilitates fetal lung maturation, however the mechanisms responsible are largely unknown. This study examines whether changes in versican levels or sulphation patterns of
Annie R. A. McDougall, Amanda J. Fosang, Jessica Faggian, Megan J. Wallace, Kelly J. Crossley, Timothy J. Cole, Stuart B. Hooper   +6 more
doaj   +1 more source