Results 111 to 120 of about 15,922 (221)

Deposition of insoluble elastin by pulmonary fibroblasts from patients with COPD is increased by treatment with versican siRNA

open access: yesInternational Journal of COPD, 2017
Lian Wu,1,2 Jing Zhang,3 Jie Ming Qu,4 Chun-xue Bai,3 Mervyn J Merrilees5 1Department of Community and Health Services, Unitec, 2Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand; 3Department of ...
Wu L   +4 more
doaj  

Homozygous Recessive Versican Missense Variation Is Associated With Early Teeth Loss in a Pakistani Family

open access: yesFrontiers in Genetics, 2019
Only a few genes involved in teeth development and morphology are known to be responsible for tooth abnormalities in Mendelian-inherited diseases. We studied an inbred family of Pakistani origin in which two first-cousin born brothers are affected by ...
Stefania Bigoni   +24 more
doaj   +1 more source

Hyaluronan, a Crucial Regulator of Inflammation [PDF]

open access: yes, 2014
Hyaluronan (HA), a major component of the extracellular matrix (ECM), plays a key role in regulating inflammation. Inflammation is associated with accumulation and turnover of HA polymers by multiple cell types.
Aaron C. Petrey, Carol A. de la Motte
core   +2 more sources

Proteolytic Cleavage of Versican During Limb Joint Development [PDF]

open access: yesThe Anatomical Record, 2010
AbstractVersican is highly expressed in developing joint interzones during limb morphogenesis. This study was undertaken to examine whether proteolytic cleavage of versican occurs that could potentially impact its function during the process of embryonic synovial joint formation.
openaire   +2 more sources

The extracellular matrix in multiple sclerosis: an update

open access: yesBrazilian Journal of Medical and Biological Research, 2001
Extracellular matrix (ECM) molecules play important roles in the pathobiology of the major human central nervous system (CNS) inflammatory/demyelinating disease multiple sclerosis (MS). This mini-review highlights some recent work on CNS endothelial cell
R.A. Sobel
doaj   +1 more source

Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome [PDF]

open access: yes, 2006
Arterial tortuosity syndrome (ATS) is an autosomal recessive disorder characterized by tortuosity, elongation, stenosis and aneurysm formation in the major arteries owing to disruption of elastic fibers in the medial layer of the arterial wall1 ...
Barlati S   +17 more
core   +1 more source

Extracellular matrix of the central nervous system: from neglect to challenge [PDF]

open access: yes, 2018
The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins and tenascins (Tn-R, Tn-C) can regulate cellular migration and axonal ...
Dours-Zimmermann, MarĂ­a   +1 more
core  

Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon [PDF]

open access: yes, 2006
To profile the messenger RNA (mRNA) expression for the 23 known genes of matrix metalloproteinases (MMPs), 19 genes of ADAMTS, 4 genes of tissue inhibitors of metalloproteinases (TIMPs), and ADAM genes 8, 10, 12, and 17 in normal, painful, and ruptured ...
Alfredson   +73 more
core   +1 more source

Interleukin-11 Promotes the Progress of Gastric Carcinoma via Abnormally Expressed Versican

open access: yesInternational Journal of Biological Sciences, 2012
Versican, a ubiquitous component of the extracellular matrix (ECM), accumulates both in tumor stroma and cancer cells and is highly regulated by various cytokines.
Zhenwei Zhang, Jianpeng Zhang, Lei Miao, Ke Liu, Shengsheng Yang, Chuanyong Pan, Binghua Jiao
doaj  

DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown [PDF]

open access: yes, 2011
Damage-associated molecular patterns (DAMPs) or cell death associated molecular patterns (CDAMPs) are a subset of endogenous intracellular molecules that are normally hidden within living cells but become either passively released by primary and ...
Agostinis, Patrizia   +3 more
core   +1 more source

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