Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on VCAN (versican), with data on DNA, on the protein encoded, and where the gene is implicated.
Hernández, D, Docampo, MJ, Bassols, A
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CBP phosphorylation maintains intestinal homeostasis by supporting the stem cell niche through versican [PDF]
Nature CommunicationsCREB-binding protein (CBP) is a transcriptional coactivator, and we reported its phosphorylation regulates cell fate. Impaired CBP phosphorylation alters its binding preference for p53 in CBP AA mice, leading to distal colonic abnormalities.
Yi-Ting Lin +5 more
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Inflammation Amplification by Versican: The First Mediator [PDF]
International Journal of Molecular Sciences, 2012 The effects of inflammation may not always benefit the individual. Its amplifying nature represents a highly regulated biological program, and the inflammatory microenvironment is its essential component. Growing evidence suggests that the ECM (extracellular matrix) is important for the early steps of inflammation.
Zhang, Zhenwei +2 more
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Versican regulating viscoelasticity drives pleural fibrosis via mechanotransductive signaling [PDF]
JCI InsightExtracellular matrix (ECM) disorder was believed to result from fibrosis, but it has recently been recognized that fibrotic ECM initiates a self-reinforcing circuit and contributes to the development of fibrosis.
Zi-Heng Jia +19 more
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Immunohistochemical and biochemical assay of versican in human sound predentine/dentine matrix [PDF]
European Journal of Histochemistry, 2009 Aim of this study was to investigate the distribution of versican proteoglycan within the human dentine organic matrix by means of a correlative immunohistochemical analysis with field emission in-lens scanning electron microscope (FEI-SEM), transmission
A. Ruggeri +9 more
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Effect of modulating the extracellular matrix cross linkage by genipin on tumor cell resistance and survival in thioacetamide-induced hepatocellular carcinoma in rats [PDF]
PeerJBackground Previous studies on patients and rats with hepatocellular carcinoma (HCC) have shown significant changes in the extracellular matrix (ECM). Versican, a component of the ECM, forms extensive multimolecular interactions with other ECM components,
Hanan M. Hassan +10 more
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Versican modulates tumor-associated macrophage properties to stimulate mesothelioma growth
OncoImmunology, 2019 Versican promotes experimental tumor growth through cell- and non cell-autonomous mechanisms. Its role in mesothelioma progression has not been investigated so far.
Apostolos G. Pappas +8 more
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Versican is differentially regulated in the adventitial and medial layers of human vein grafts. [PDF]
PLoS ONE, 2018 Changes in extracellular matrix proteins may contribute significantly to the adaptation of vein grafts to the arterial circulation. We examined the production and distribution of versican and hyaluronan in intact human vein rings cultured ex vivo, veins ...
Richard D Kenagy +14 more
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Versican Expression during Synovial Joint Morphogenesis
International Journal of Biological Sciences, 2007 The extracellular matrix (ECM) plays a critical role in governing cell behavior and phenotype during limb skeletogenesis. Chondroitin sulfate proteoglycans (Cspgs) are highly expressed in the ECM of precartilage mesenchymal condensations and are ...
John B. Shepard, Heidi A. Krug, Brooklynn A. LaFoon, Stanley Hoffman, Anthony A. Capehart
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Promotor Hypomethylation Mediated Upregulation of VCAN Targets Twist1 to Promote EndMT in Hypoxia‐Induced Pulmonary Hypertension [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Hypoxia‐induced pulmonary hypertension (HPH) is a severe vascular disorder that is characterized by the involvement of endothelial‐to‐mesenchymal transition (EndMT) in its pathogenesis.
Jinyan Yu +10 more
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