Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages. [PDF]
PLoS ONE, 2015 Hypoxia is a hallmark of many pathological tissues. Macrophages accumulate in hypoxic sites and up-regulate a range of hypoxia-inducible genes. The matrix proteoglycan versican has been identified as one such gene, but the mechanisms responsible for ...
Fattah Sotoodehnejadnematalahi +5 more
doaj +15 more sources
Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation
Frontiers in Immunology, 2020 The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 (TSG-6), and inter alpha trypsin inhibitor (IαI) during inflammation in a number ...
Thomas N Wight +2 more
exaly +3 more sources
Respiratory Research, 2023 Background and aims This study aimed to investigate the expression of plasma versican and plasma exosomal versican in non-small cell lung cancer (NSCLC) and its correlation with clinicopathological features, and to evaluate its diagnostic performance in ...
Wenjing Chang +6 more
doaj +3 more sources
Structure, Function and Regulation of Versican: The Most Abundant Type of Proteoglycan in the Extracellular Matrix [PDF]
Acta Medica Iranica, 2013 One of the main members of the large aggregating proteoglycans (PGs) family is versican which is able to bind to hyaluronate. Versican is a chondroitin sulfate proteoglycan and is a key ingredient of the extracellular matrix.
Fattah Sotoodehnejadnematalahi +1 more
doaj +3 more sources
Cell Reports, 2020 Summary: Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obesity.
Chang Yeop Han +2 more
exaly +3 more sources
Effect of modulating the extracellular matrix cross linkage by genipin on tumor cell resistance and survival in thioacetamide-induced hepatocellular carcinoma in rats [PDF]
PeerJBackground Previous studies on patients and rats with hepatocellular carcinoma (HCC) have shown significant changes in the extracellular matrix (ECM). Versican, a component of the ECM, forms extensive multimolecular interactions with other ECM components,
Hanan M. Hassan +10 more
doaj +3 more sources
Promotor Hypomethylation Mediated Upregulation of VCAN Targets Twist1 to Promote EndMT in Hypoxia‐Induced Pulmonary Hypertension [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Hypoxia‐induced pulmonary hypertension (HPH) is a severe vascular disorder that is characterized by the involvement of endothelial‐to‐mesenchymal transition (EndMT) in its pathogenesis.
Jinyan Yu +10 more
doaj +2 more sources
The Dual Role of ADAMTS1 in Cardiovascular Remodeling: Balancing Extracellular Matrix Homeostasis and Pathological States [PDF]
Journal of Cardiovascular Development and DiseaseExtracellular matrix metalloproteinase ADAMTS1 (adhesion metalloproteinase with thrombospondin-type domain 1) is a key regulator in cardiovascular remodeling with functional paradoxes.
Siqin Sheng, Shunrong Zhang
doaj +2 more sources
Versican Expression during Synovial Joint Morphogenesis [PDF]
International Journal of Biological Sciences, 2007 The extracellular matrix (ECM) plays a critical role in governing cell behavior and phenotype during limb skeletogenesis. Chondroitin sulfate proteoglycans (Cspgs) are highly expressed in the ECM of precartilage mesenchymal condensations and are ...
John B. Shepard, Heidi A. Krug, Brooklynn A. LaFoon, Stanley Hoffman, Anthony A. Capehart
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Versican expression from lung fibroblasts suppresses pulmonary fibrosis [PDF]
Nature CommunicationsThe activation and accumulation of lung fibroblasts, leading to excessive ECM deposition, is a pathogenic hallmark of Idiopathic Pulmonary Fibrosis, a lethal and currently untreatable disease.
Paraskevi Kanellopoulou +20 more
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