Results 51 to 60 of about 7,117 (194)

Evidence for the control of aggrecanases by insulin and glucose in Alzheimer’s disease

Psychiatry and Clinical Psychopharmacology, 2021
Objective: Alzheimer’s disease (AD) is a progressive and irreversible central nervous system disease, which slowly destroys cognitive skills and memory, and eventually even the ability to handle the simplest tasks.
Sumeyya Akyol, Veli Ugurcu, Ozlem Cakmak, Aynur Altuntas, Yunus Yukselten, Omer Akyol, Asuman Sunguroglu, Kadir Demircan   +7 more
doaj   +1 more source

Degradomics defines proteolysis information flow from human knee osteoarthritis cartilage to matched synovial fluid and the contributions of secreted proteases ADAMTS5, MMP13 and CMA1 to articular cartilage breakdown

Osteoarthritis and Cartilage
SUMMARY Objectives: Proteolytic cartilage extracellular matrix breakdown is a major mechanism of articular cartilage loss in osteoarthritis (OA) pathogenesis.
Sumit Bhutada, A. Hoyle, Nicolas S. Piuzzi, S. Apte   +3 more
semanticscholar   +1 more source

lncRNA PSMB8-AS1 promotes colorectal cancer progression through sponging miR-1299 to upregulate ADAMTS5.

Neoplasma (Bratislava), 2022
Long non-coding RNAs (lncRNAs) have been reported to be vital participants in tumor progression. Recently, lncRNA PSMB8-AS1 has been uncovered to facilitate pancreatic cancer progression by regulating miR-382-3p/STAT1/PD-L1 network. Nonetheless, the role
Fang Zhao, Meng Wang, Yibin Zhang, Rujuan Su, Chenyang He, Xiaomei Gao, Ying Zan, Shuqun Zhang, Yuguang Ma, Chao Liu   +9 more
semanticscholar   +1 more source

Does butein affect adipogenesis?

Adipocyte, 2019
Butein is a plant flavonoid chalcone, with presumed anti-adipogenic properties. It was reported to impair preadipocyte differentiation, limit adipose tissue (AT) development and enhance white AT browning in rodents.
Bianca Hemmeryckx, Christine Vranckx, Dries Bauters, H. Roger Lijnen, Ilse Scroyen   +4 more
doaj   +1 more source

HOXC13-AS Induced Extracellular Matrix Loss via Targeting miR-497-5p/ADAMTS5 in Intervertebral Disc

Frontiers in Molecular Biosciences, 2021
Background/Aims: LncRNAs are a new modulator in the development of intervertebral disc degeneration. However, the functional role and mechanism of HOXC13-AS in intervertebral disc degeneration remain unclear.Methods: qRT-PCR analysis was performed to ...
Wanli Jing, Wei Liu
doaj   +1 more source

The Rab25‐ADAMTS5 axis as a previously undescribed mechanism for sensing tumor microenvironment complexity

The FEBS Journal
The tumor microenvironment (TME), particularly the extracellular matrix (ECM), plays a critical role in cancer progression. Focusing on ovarian cancer, Yuan et al.
François Tyckaert, Francesco Baschieri
semanticscholar   +1 more source

Differential DNA methylation analysis of SUMF2, ADAMTS5, and PXDN provides novel insights into colorectal cancer prognosis prediction in Taiwan

World Journal of Gastroenterology, 2022
BACKGROUND Patients with colorectal cancer (CRC) undergo surgery, as well as perioperative chemoradiation or adjuvant chemotherapy primarily based on the tumor–node– metastasis (TNM) cancer staging system.
Jing-Quan Su, P. Lai, Pei Hu, Je-Ming Hu, Pi-Kai Chang, Chao-Yang Chen, Jia-Jheng Wu, Yu-Jyun Lin, Chien‐An Sun, Tsan Yang, Chih-Hsiung Hsu, Hua-Ching Lin, Y. Chou   +12 more
semanticscholar   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

SP1‑mediated ADAMTS5 transcription promotes IL‑1β‑induced chondrocyte injury via Wnt/β‑catenin pathway in osteoarthritis

Molecular Medicine Reports
Osteoarthritis (OA) is a chronic disease that involves chondrocyte injury. ADAMTS5 has been confirmed to mediate chondrocyte injury and thus regulate OA progression, but its underlying molecular mechanisms remain unclear.
Xiaoting Hao, Xiaxia Wu
semanticscholar   +1 more source