Results 71 to 80 of about 7,117 (194)

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5 [PDF]

Protein Science, 2008
AbstractAggrecanases are now believed to be the principal proteinases responsible for aggrecan degradation in osteoarthritis. Given their potential as a drug target, we solved crystal structures of the two most active human aggrecanase isoforms, ADAMTS4 and ADAMTS5, each in complex with bound inhibitor and one wherein the enzyme is in apo form.
Lidia, Mosyak, Katy, Georgiadis, Tania, Shane, Kristine, Svenson, Tracy, Hebert, Thomas, McDonagh, Stewart, Mackie, Stephane, Olland, Laura, Lin, Xiaotian, Zhong, Ronald, Kriz, Erica L, Reifenberg, Lisa A, Collins-Racie, Christopher, Corcoran, Bethany, Freeman, Richard, Zollner, Tod, Marvell, Matthew, Vera, Phaik-Eng, Sum, Edward R, Lavallie, Mark, Stahl, William, Somers   +21 more
openaire   +2 more sources

Elevation of MMP1 and ADAMTS5 mRNA expression in glenohumeral synovia of patients with hypercholesterolemia

Journal of Orthopaedic Surgery and Research, 2022
Background Epidemiological studies have reported a positive association between hypercholesterolemia and shoulder disease. Previous studies have focused on the effect of hypercholesterolemia on tendinopathy.
Kyoko Muneshige, Kentaro Uchida, Tomonori Kenmoku, Ryo Tazawa, Mitsufumi Nakawaki, Daisuke Ishii, Gen Inoue, Masashi Takaso   +7 more
doaj   +1 more source

Artificial Chlorella Biohybrids for Alleviation of Cartilage Degeneration in Osteoarthritis

Exploration, EarlyView.
Artificial Chlorella biohybrids (Ch@P) alleviate cartilage degeneration and protect against OA progression by activating mitophagy and reprogramming glucose metabolism in chondrocytes, as well as inducing articular thermal stimulation under near infrared irradiation.
Yongyun Chang, Keyu Kong, Minghao Jin, Shasha Liu, Yangzi Yang, Yingchun Zhu, Hua Qiao, Wenxuan Fan, Xinru Wu, Jingwei Zhang, Yansong Qi, Yongsheng Xu, Xiang Feng, Pingcuo Nima, Piting Ji, Tariel Mamuladze, Andrei A. Korytkin, Huiwu Li, Jingke Fu, Zanjing Zhai   +19 more
wiley   +1 more source

Activation of β-catenin signalling leads to temporomandibular joint defects [PDF]

European Cells & Materials, 2014
Despite extensive research in knee and hip osteoarthritis (OA), the underlying mechanism of temporomandibular joint (TMJ) disorder remains largely unknown. The purpose of this study was to determine whether the constitutive activation of β-catenin in the
M Wang, S Li, W Xie, J Shen, H-J Im, JD Holz, M Wang, TGH Diekwisch, D Chen   +8 more
doaj  

Investigating the association between serum ADAM/ADAMTS levels and bone mineral density by mendelian randomization study

BMC Genomics, 2023
Purpose A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) have been reported potentially involved in bone metabolism and related to bone mineral density. This Mendelian Randomization (MR)
Xin Lv, Yuhong Lin, Zhilei Zhang, Bo Li, Ziliang Zeng, Xu Jiang, Qiancheng Zhao, Wenpeng Li, Zheyu Wang, Canchun Yang, Haolin Yan, Qiwei Wang, Renyuan Huang, Xumin Hu, Liangbin Gao   +14 more
doaj   +1 more source

Schisandrol A Suppresses Catabolic Factor Expression by Blocking NF-κB Signaling in Osteoarthritis

Pharmaceuticals, 2021
Schisandrol A possesses pharmacological properties and is used to treat various diseases; however, its effects on osteoarthritis (OA) progression remain unclear. Here, we investigated Schisandrol A as a potential therapeutic agent for OA.
Seong Jae Han, Jimoon Jun, Seong-il Eyun, Choong-Gu Lee, Jimin Jeon, Cheol-Ho Pan   +5 more
doaj   +1 more source

The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25

bioRxiv
Ovarian cancer is the 3rd most common gynaecological malignancy worldwide, with a 5-year survival rate of less than 30% in the presence of metastasis. Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily
Shengnan Yuan, Rachele Bacchetti, Jamie Adams, Elena Rainero   +3 more
semanticscholar   +1 more source

The Effects of TNF-α Inhibition on the Metabolism of Cartilage: Relationship between KS, HA, HAPLN1 and ADAMTS4, ADAMTS5, TOS and TGF-β1 Plasma Concentrations in Patients with Juvenile Idiopathic Arthritis

Journal of Clinical Medicine, 2022
We assessed the effect of 24-month anti-tumor necrosis factor alpha (TNF-α) treatment on the remodeling of the cartilage extracellular matrix (ECM) in patients with juvenile idiopathic arthritis (JIA). Methods: Quantitative evaluation of keratan sulfate (
K. Kuźnik-Trocha, K. Winsz-Szczotka, I. Lachór-Motyka, Klaudia Dąbkowska, Magdalena Wojdas, K. Olczyk, K. Komosińska-Vassev   +6 more
semanticscholar   +1 more source

IGF2BP3 Overexpression Accelerates Osteoarthritis Progression by Promoting Glycolysis via m6A‐Dependent Stabilization of ECM1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT N6‐methyladenosine (m6A) plays a critical role in osteoarthritis (OA) pathogenesis. This study investigates the role of the m6A reader insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3) in OA progression. OA models were established in vivo through destabilization of the medial meniscus (DMM) surgery in mice and in vitro by ...
Xing‐Shi Yuan, Hao‐Jie Zhang, Jia‐Xiang Ding, Zheng‐Liang Luo, Min Chen, Xiao‐Qi Zhang, Xi‐Fu Shang, Zhe Ni, Ke‐Rong Wu   +8 more
wiley   +1 more source

Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis

Arthritis Research & Therapy, 2018
Background ADAMTS aggrecanases play a major role in cartilage degeneration during degenerative and inflammatory arthritis. The cartilage-specific secreted protein Upper zone of growth plate and cartilage matrix associated protein (Ucma) has been shown to
Fritz Seuffert, Daniela Weidner, Wolfgang Baum, Georg Schett, Michael Stock   +4 more
doaj   +1 more source