Results 21 to 30 of about 2,930,787 (173)

Danshensu inhibits the IL-1β-induced inflammatory response in chondrocytes and osteoarthritis possibly via suppressing NF-κB signaling pathway

Molecular Medicine, 2021
Purpose Osteoarthritis (OA) is the most common inflammatory disease associated with pain and cartilage destruction. Interleukin (IL)-1β is widely used to induce inflammatory response in OA models.
Zhixian Xu, Tie Ke, Yongfa Zhang, Licheng Guo, Feng Chen, Wubing He   +5 more
doaj   +1 more source

Identification of New Key Genes and Their Association with Breast Cancer Occurrence and Poor Survival Using In Silico and In Vitro Methods

Biomedicines, 2023
Breast cancer is one of the most prevalent types of cancer diagnosed globally and continues to have a significant impact on the global number of cancer deaths.
Rafat Ali, Armiya Sultan, Romana Ishrat, Shafiul Haque, Nida Jamil Khan, Miguel Angel Prieto   +5 more
doaj   +1 more source

Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis

Frontiers in Pharmacology, 2021
Osteoarthritis (OA), which is identified by chronic pain, impacts the quality of life. Cartilage degradation and inflammation are the most relevant aspects involved in its development.
Wenbin Pei, Xiaojian Huang, Bowei Ni, Rui Zhang, Guangyi Niu, Hongbo You   +5 more
doaj   +1 more source

The ADAMTS5 Metzincin Regulates Zebrafish Somite Differentiation [PDF]

, 2018
The ADAMTS5 metzincin, a secreted zinc-dependent metalloproteinase, modulates the extracellular matrix (ECM) during limb morphogenesis and other developmental processes.
Joachim Berger, Smith, AD, Liongue, C, Ward, Alister C., Adam Smith, Daniel McCulloch, Dancevic, Carolyn M., McCulloch, Daniel R., Stupka, N, Gibert, Yann, Gibert, Y, Ward, AC, Berger, Joachim, Alister Ward, Smith, Adam D., Stupka, Nicole, Nicole Stupka, McCulloch, DR, Carolyn Dancevic, Berger, J, Yann Gibert, Clifford Liongue, Liongue, Clifford, Dancevic, CM   +23 more
core   +1 more source

Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis

Arthritis Research & Therapy, 2018
Background ADAMTS aggrecanases play a major role in cartilage degeneration during degenerative and inflammatory arthritis. The cartilage-specific secreted protein Upper zone of growth plate and cartilage matrix associated protein (Ucma) has been shown to
Fritz Seuffert, Daniela Weidner, Wolfgang Baum, Georg Schett, Michael Stock   +4 more
doaj   +1 more source

Loss of MEN1 leads to renal fibrosis and decreases HGF‐Adamts5 pathway activity via an epigenetic mechanism

Clinical and Translational Medicine, 2022
Background Renal fibrosis is a serious condition that results in the development of chronic kidney diseases. The MEN1 gene is an epigenetic regulator that encodes the menin protein and its role in kidney tissue remains unclear.
Bangming Jin, Jiamei Zhu, Yuxia Zhou, Li Liang, Yunqiao Yang, Lifen Xu, Tuo Zhang, Po Li, Ting Pan, Bing Guo, Tengxiang Chen, Haiyang Li   +11 more
doaj   +1 more source

Velvet antler polypeptide partially rescue facet joint osteoarthritis-like phenotype in adult β-catenin conditional activation mice

BMC Complementary and Alternative Medicine, 2019
Background Wnt/β-catenin signaling pathway is closely related to osteoarthritis. In our preliminary study, β-catenin conditional activation (cAct) mice that specifically over-express β-catenin gene in cartilage chondrocyte exhibits osteoarthritis-like ...
Wan-qing Xie, Yong-jian Zhao, Feng Li, Bing Shu, Shu-ru Lin, Li Sun, Yong-jun Wang, Hong-xin Zheng   +7 more
doaj   +1 more source

Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway

Frontiers in Pharmacology, 2022
Osteoarthritis is a worldwide joint disease caused by abnormal chondrocytic metabolism. However, traditional therapeutic methods aimed at anti-inflammation for early-stage disease are palliative.
Minjun Yao, Minjun Yao, Caihua Zhang, Lingzhi Ni, Lingzhi Ni, Xiaoxiao Ji, Xiaoxiao Ji, Jianqiao Hong, Jianqiao Hong, Yazhou Chen, Yazhou Chen, Jie Wang, Jie Wang, Congsun Li, Congsun Li, Jiyan Lin, Jiyan Lin, Tingting Lu, Yihao Sheng, Menghao Sun, Menghao Sun, Mingmin Shi, Mingmin Shi, Chenhe Zhou, Chenhe Zhou, Xunzi Cai, Xunzi Cai   +26 more
doaj   +1 more source

CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]

, 2018
Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry, Hendershot, Linda M., Feige, Matthias J., Ineke Braakman, Matthias J. Feige, Braakman, Ineke, Cellular Protein Chemistry, Linda M. Hendershot   +7 more
core   +1 more source

FGF receptor inhibitor BGJ398 partially rescues osteoarthritis-like phenotype in older high molecular weight FGF2 transgenic mice via multiple mechanisms

Scientific Reports, 2022
We have used Basic Fibroblast Growth Factor (FGF2) transgenic mice as experimental models for human X-linked hypophosphatemia (XLH)-related degenerative osteoarthritis (OA) to investigate the pathogenesis of the disease and to test potential ...
Marja M. Hurley, J. Douglas Coffin, Thomas Doetschman, Christina Valera, Kai Clarke, Liping Xiao   +5 more
doaj   +1 more source