Results 11 to 20 of about 2,930,787 (173)
ADAMTS5 Is a Critical Regulator of Virus-Specific T Cell Immunity. [PDF]
PLoS Biology, 2016 The extracellular matrix (ECM) provides physical scaffolding for cellular constituents and initiates biochemical and biomechanical cues that are required for physiological activity of living tissues.
Meagan McMahon +7 more
doaj +3 more sources
Journal of Orthopaedic Surgery and Research, 2021 Background Osteoarthritis (OA) is responsible for the impotent disability in old people. Circular RNA (circRNA) has been reported to be related to the development of diseases. The lack of research on the role of circRNA spastic paraplegia 11 (circ-SPG11)
Yongqiang Liu +4 more
doaj +2 more sources
Molecular Metabolism, 2017 Objective: A potential strategy to treat obesity – and the associated metabolic consequences – is to increase energy expenditure. This could be achieved by stimulating thermogenesis through activation of brown adipose tissue (BAT) and/or the induction of
Dries Bauters +5 more
doaj +2 more sources
Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage [PDF]
European Cells & Materials, 2011 The relative contribution of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)4 and ADAMTS5 to aggrecan degradation under oncostatin M (OSM) stimulation, the role of the ancillary domains of the aggrecanases on their ability to ...
M Durigova +4 more
doaj +2 more sources
Evidence for the control of aggrecanases by insulin and glucose in Alzheimer’s disease
Psychiatry and Clinical Psychopharmacology, 2021 Objective: Alzheimer’s disease (AD) is a progressive and irreversible central nervous system disease, which slowly destroys cognitive skills and memory, and eventually even the ability to handle the simplest tasks.
Sumeyya Akyol +7 more
doaj +1 more source
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. [PDF]
, 2020 Cerebral cavernous malformations (CCMs) form following loss of the CCM protein complex in brain endothelial cells due to increased endothelial MEKK3 signaling and KLF2/4 transcription factor expression, but the downstream events that drive lesion ...
Tang AT +29 more
core +1 more source
Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis
Cell Death and Disease, 2022 A Disintegrin and Metalloproteinase with ThromboSpondin motif (ADAMTS) 5 functions as an anti-angiogenic and anti-cancer protein independent of its metalloproteinase activity. Both full-length ADAMTS5 and TS5-p45, the autocatalytically cleaved C-terminal
Dogan Can Kirman +5 more
doaj +1 more source
Naringenin attenuates inflammation and apoptosis of osteoarthritic chondrocytes via the TLR4/TRAF6/NF-κB pathway [PDF]
PeerJ, 2023 Naringenin is a flavonoid extracted from the seed coat of Anacardiaceae plants. Increasing evidence indicates that it has several properties of biological significance, such as anti-infection, sterilization, anti-allergy, antioxidant free radical, and ...
Yan Wang +4 more
doaj +2 more sources
Autoimmunity, 2022 Background Osteoarthritis (OA) is a common joint disease characterized by progressive cartilage degradation. Circular RNAs (circRNAs) are involved in the initiation and development of OA.
Zhongxing Liu +6 more
doaj +1 more source
Studying protein-protein interactions using peptide arrays [PDF]
, 2010 Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T. +7 more
core +1 more source