Results 31 to 40 of about 2,930,787 (173)
Does butein affect adipogenesis?
Adipocyte, 2019 Butein is a plant flavonoid chalcone, with presumed anti-adipogenic properties. It was reported to impair preadipocyte differentiation, limit adipose tissue (AT) development and enhance white AT browning in rodents.
Bianca Hemmeryckx +4 more
doaj +1 more source
Functional role of ADAMTS5 in adiposity and metabolic health. [PDF]
, 2018 Previous studies with gene-deficient mice (ADAMTS5-P) revealed that ADAMTS5 (A Disintegrin And Metalloproteinase with Thrombospondin type 1 motifs, member 5) plays a functional role in adiposity and metabolic health.
Henri Roger Lijnen +3 more
core +1 more source
IGF-1 Upregulates Biglycan and Decorin by Increasing Translation and Reducing ADAMTS5 Expression
, 2021 Proteoglycan (PG) is a glycosaminoglycan (GAG)-conjugated protein essential for maintaining tissue strength and elasticity. The most abundant skin PGs, biglycan and decorin, have been reported to decrease as skin ages. Insulin-like growth factor-1 (IGF-1)
Lee, Hanon +9 more
core +1 more source
miR-21-5p protects IL-1β-induced human chondrocytes from degradation
Journal of Orthopaedic Surgery and Research, 2019 Objective Osteoarthritis (OA) is a prevalent degenerative disease caused by various factors. MicroRNAs are important regulators in OA. MiR-21-5p expression is decreased in OA cartilage, but the effects of modulating miR-21-5p on cartilage regeneration ...
Hai Zhu +4 more
doaj +1 more source
, 2017 Previous studies have indicated the important roles of ADAMTS5 in intervertebral disc degeneration (IDD). However, the mechanisms that regulate ADAMTS5 expression in nuclear pulposus (NP) cells remain largely unknown.
Yukun Zhang +10 more
core +1 more source
Полиморфные варианты гена ADAMTS5 – новые маркеры гипермобильности суставов [PDF]
, 2023 Joint hypermobility (JH) is a common phenotype that can be both an independent clinical syndrome and a manifestation of connective tissue diseases. The pathogenesis of JH is not well understood.
R. I. Khusainova +7 more
core +1 more source
ADAMTS5 deficiency in mice does not affect cardiac function
, 2019 The aggrecanase ADAMTS5 (A Disintegrin and Metalloproteinase with ThromboSpondin type 1 motifs, member 5) and the cleavage of its substrate versican have been implicated in the development of heart valves.
Bianca Hemmeryckx +5 more
core +1 more source
A transcriptional enhancer from the coding region of ADAMTS5. [PDF]
PLoS ONE, 2008 The revelation that the human genome encodes only approximately 25,000 genes and thus cannot account for phenotypic complexity has been one of the biggest surprises in the post-genomic era.
Kristen K B Barthel, Xuedong Liu
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Background: Bone marrow stimulation (BMS) is the most used operative treatment in repairing cartilage defect clinically, but always results in fibrocartilage formation, which is easily worn out and needs second therapy.
Xiongbo Song +11 more
doaj +1 more source
Advanced Science, EarlyView.An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng +9 more
wiley +1 more source