Results 31 to 40 of about 2,012 (172)
Arthritis Research & Therapy, 2017 Background A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues.
Per Swärd +5 more
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Computational and Structural Biotechnology Journal, 2021 Articular cartilage is connective tissue that forms a slippery load-bearing joint surface between bones. With outstanding mechanical properties, it plays an essential role in cushioning impact and protecting the ends of bones.
Yen-Yu Lai, Deng Li, Shu-Wei Chang
doaj +1 more source
Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage [PDF]
European Cells & Materials, 2011 The relative contribution of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)4 and ADAMTS5 to aggrecan degradation under oncostatin M (OSM) stimulation, the role of the ancillary domains of the aggrecanases on their ability to ...
M Durigova +4 more
doaj
Arthritis Research & Therapy, 2018 Background ADAMTS aggrecanases play a major role in cartilage degeneration during degenerative and inflammatory arthritis. The cartilage-specific secreted protein Upper zone of growth plate and cartilage matrix associated protein (Ucma) has been shown to
Fritz Seuffert +4 more
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Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide
Scientific Reports, 2021 ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA).
Salvatore Santamaria +9 more
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Cartilage degradation independent of MMP/aggrecanases [PDF]
Osteoarthritis and Cartilage, 2004 To identify and characterize a cartilage degradation mechanism that is independent of the proteolytic cleavages by matrix metalloproteinases (MMPs) and aggrecanases.The sensitivity of glycosaminoglycan (GAG) release and collagen release to an MMP/aggrecanase inhibitor, AG3340, was compared using a bovine nasal cartilage explant culture.
Sugimoto, Kotaro +5 more
openaire +2 more sources
Role of aggrecanase 1 in Lyme arthritis [PDF]
Arthritis & Rheumatism, 2006 AbstractObjectiveArthritis is one of the hallmarks of late‐stage Lyme disease. Previous studies have shown that infection with Borrelia burgdorferi, the causative agent of Lyme disease, results in degradation of proteoglycans and collagen in cartilage. B burgdorferi do not appear to produce any exported proteases capable of digesting proteoglycans and ...
Behera, Aruna K. +10 more
openaire +3 more sources
Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis
Brazilian Journal of Medical and Biological Research, 2019 Aggrecanase-2 (ADAMTS5) gene is responsible for aggrecan degradation that may contribute to cartilage destruction in a mouse osteoarthritis (OA) model. We aimed to investigate the effects of ADAMTS5 gene polymorphisms on OA risk in a Chinese population ...
Xindie Zhou +7 more
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Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Advanced NanoBiomed Research, Volume 6, Issue 9, September 2026.Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
Regulation of ADAMTS Proteases
Frontiers in Molecular Biosciences, 2021 A disintegrin and metalloprotease with thrombospondin type I motifs (ADAMTS) proteases are secreted metalloproteinases that play key roles in the formation, homeostasis and remodeling of the extracellular matrix (ECM).
Keron W. J. Rose +3 more
doaj +1 more source