Results 51 to 60 of about 2,012 (172)
Smart Medicine, Volume 5, Issue 4, August 2026.Organ‐on‐a‐chip to miniaturize the human intervertebral disc in modeling key degenerative features, including ECM degradation, inflammation, neovascularization, sensory innervation, and nociception toward precision translation for studying disease mechanisms and therapeutic testing.
Izzat Zulkiflee +3 more
wiley +1 more source
Osteoarthritis: Epidemiology, Diagnosis, and Treatment
MedComm, Volume 7, Issue 7, July 2026.Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru +7 more
wiley +1 more source
Scientific Reports, 2022 Obesity is a significant risk factor for the development of knee osteoarthritis (KOA). However, the precise molecular mechanisms linking obesity to OA remain unclear.
Hebatallah Mohammed Aboudeya +2 more
doaj +1 more source
Hyaluronan (HA) Receptors: Discovery, Function & Pathology
Proteoglycan Research, Volume 4, Issue 3, July 2026.ABSTRACT Hyaluronan (HA) is typically a long polymer of the repeating disaccharide, glucuronic acid‐β‐(1‐3)‐N‐acetylglucosamine polymerized by β(1‐4) bonds, with no obvious active site for biological activity. However, this dynamic polymer is vital for life in all metazoans and has a diverse array of functional characteristics due to the proteins that ...
Abby E. Bopp +8 more
wiley +1 more source
Global Spine Journal, 2012 Introduction Nutritional supply of cells within the avascular intervertebral disk occurs mainly by diffusion from the blood vessels ending at the endplate of the vertebral body. With proceeding disk degeneration and calcification of the endplate the main
A. Mietsch +4 more
doaj +1 more source
The FEBS Journal, Volume 293, Issue 13, Page 3788-3813, July 2026.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
The role of aggrecan in normal and osteoarthritic cartilage
Journal of Experimental Orthopaedics, 2014 Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads.
Peter J Roughley, John S Mort
doaj +1 more source
Scientific Reports, 2020 A key feature of osteoarthritis is the gradual loss of articular cartilage and bone deformation, resulting in the impairment of joint function. The primary cause of cartilage destruction is considered to be the presence of elevated proteases, such as ...
Hiroyuki Nakamura +4 more
doaj +1 more source
The FEBS Journal, Volume 293, Issue 13, Page 3848-3864, July 2026.Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki +4 more
wiley +1 more source
Reoxygenation enhances tumour necrosis factor alpha-induced degradation of the extracellular matrix produced by chondrogenic cells [PDF]
European Cells & Materials, 2016 Mesenchymal stem cells (MSCs) have been considered as a potential source for cell-based therapies in arthritic diseases for both their chondrogenic and anti-inflammatory properties. Thus, we examined how MSC-based neocartilage responds to tumour necrosis
BD Markway +6 more
doaj +1 more source