Results 71 to 80 of about 2,012 (172)

Early Post‑Traumatic Osteoarthritis Features Greater Cartilage Extracellular Matrix Proteoglycan Loss Compared to the Pericellular Matrix

Journal of Orthopaedic Research, Volume 44, Issue 5, May 2026.
ABSTRACT Proteoglycan loss in articular cartilage is a hallmark of post‐traumatic osteoarthritis, and it can affect both chondrocyte biomechanics and tissue health. Previously, we found that 4 weeks after anterior cruciate ligament transection (ACLT) in rabbits, proteoglycan loss was less pronounced in the pericellular matrix (PCM) than in the ...
Rasmus K. Hiltunen, Nina Pesonen, Simo P. Ojanen, Mikko A. J. Finnilä, Sanna Palosaari, Walter Herzog, Simo Saarakkala, Rami K. Korhonen, Juuso T. J. Honkanen, Petri Tanska   +9 more
wiley   +1 more source

Equine experimental lameness induction models

Equine Veterinary Education, Volume 38, Issue 5, Page 270-284, May 2026.
Summary Equine lameness due to musculoskeletal injury remains a common and significant cause of decreased performance. While our understanding and management of lameness have improved with advanced imaging, as well as diagnostic and therapeutic progression, a need for experimental equine models of lameness remains.
A. Dockery, B. Beasley, V. J. Moorman
wiley   +1 more source

Marine algae Cystoseira indica extracted alginate alleviates toxicity and inflammation pathways in Osteoarthritis induced rat model [PDF]

Egyptian Journal of Cancer and Biomedical Research
Background: Brown algae are known for synthesizing bioac-tive compounds with anti-inflammatory properties, which have shown potential in addressing inflammation-related disorders.
Mohamed Helal, Amany El-Sekaily, Mohamed Shetewy, Hoda Soliman, Abdallah Elnemr, Hossam Ghonim, Amal El-Sedfy, Aziza Saad, Jihan Hassan   +8 more
doaj   +1 more source

Hemoglobin Stimulates the Expression of Adamts-5 and -9 by Synovial Cells; A Possible Cause of Cartilage Damage after Intra-articular Bleeding

Orthopaedic Journal of Sports Medicine, 2017
Objectives: A disintegrin and metalloprotease with thrombospondin motifs (ADAMTS)-5 and -9 play an important pathologic role in matrix degeneration.
Takuya Tajima MD, PhD, Etsuo Chosa M.D., Ph.D., Noboru Taniguchi MD, PhD, Nami YAMAGUCHI MD, PhD   +3 more
doaj   +1 more source

The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation

Osteoarthritis and Cartilage, 2001
Cleavage of aggrecan between residues Glu(373)-Ala(374), which is believed to be a key event in aggrecan destruction in arthritic diseases, has been attributed to an enzymatic activity, aggrecanase. Two cartilage aggrecanases have been identified, aggrecanase-1 (ADAM-TS4) and aggrecanase-2 (ADAM-TS5) and both enzymes have been shown very efficiently to
Tortorella, M.D., Malfait, A.-M., Deccico, C., Arner, E.   +3 more
openaire   +2 more sources

Aggrecanases and cartilage matrix degradation.

Arthritis research & therapy, 2003
The loss of extracellular matrix macromolecules from the cartilage results in serious impairment of joint function. Metalloproteinases called 'aggrecanases' that cleave the Glu373-Ala374 bond of the aggrecan core protein play a key role in the early stages of cartilage destruction in rheumatoid arthritis and in osteoarthritis.
Nagase, H, Kashiwagi, M
openaire   +2 more sources

Induction of Matrix Metalloproteinases in Chondrocytes by Interleukin IL-1β as an Osteoarthritis Model

Journal of Mathematical and Fundamental Sciences, 2019
Osteoarthritis (OA) is a chronic disease of the joints and bones due to trauma or other joint-related diseases (secondary). Synovial inflammation commonly causes disturbance in joint homeostasis, which is associated with OA.
Ervi Afifah, Tjandrawati Mozef, Ferry Sandra, Seila Arumwardana, Dwi Davidson Rihibiha, Hayatun Nufus, Rizal Rizal, Annisa Amalia, Indra Bachtiar, Harry Murti, Wahyu Widowati   +10 more
doaj   +1 more source

Acute mechanical injury of the human intervertebral disc: link to degeneration and pain [PDF]

European Cells & Materials, 2014
Excessive mechanical loading or acute trauma to intervertebral discs (IVDs) is thought to contribute to degeneration and pain. However, the exact mechanisms by which mechanical injury initiates and promotes degeneration remain unclear.
B Alkhatib, DH Rosenzweig, E Krock, PJ Roughley, L Beckman, T Steffen, MH Weber, JA Ouellet, L Haglund   +8 more
doaj  

Synergetic enrichment of aggrecan in nucleus pulposus cells by scAAV6-shRNA-mediated knockdown of aggrecanase-1 and aggrecanase-2. [PDF]

Exp Biol Med (Maywood), 2023
Mern DS, Thomé C.
europepmc   +1 more source

Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition. [PDF]

J Med Chem, 2022
Cuffaro D, Ciccone L, Rossello A, Nuti E, Santamaria S.   +4 more
europepmc   +1 more source