Results 11 to 20 of about 11,494 (133)
BMC Gastroenterology, 2023 Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease that develops due to the impaired immune response in genetically susceptible individuals, and its etiopathogenesis is not fully elucidated.
Tahir Buran +6 more
doaj +1 more source
The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. [PDF]
PLoS ONE, 2015 The specific degradation of type II collagen and aggrecan by matrix metalloproteinase (MMP)-9, -13 and ADAMTS-4 and -5 (aggrecanase-1 and -2) in the cartilage matrix is a critical step in pathology of osteoarthritis (OA).
Yi He +7 more
doaj +1 more source
ADAMTS proteases in cardiovascular physiology and disease [PDF]
Open Biology, 2020 The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family comprises 19 proteases that regulate the structure and function of extracellular proteins in the extracellular matrix and blood.
Salvatore Santamaria, Rens de Groot
doaj +1 more source
Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide
Scientific Reports, 2021 ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA).
Salvatore Santamaria +9 more
doaj +1 more source
Leptin downregulates aggrecan through the p38-ADAMST pathway in human nucleus pulposus cells. [PDF]
PLoS ONE, 2014 The mechanistic basis of obesity-associated intervertebral disc degeneration (IDD) is unclear. Aberrant expression of aggrecan and its degrading enzymes ADAMTS-4 and ADAMTS-5 is implicated in the development of IDD.
Zheng Li +5 more
doaj +1 more source
The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis
Biomolecules, 2022 Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized by the inflammation of the bone leading to degeneration and loss of cartilage function.
Ting Li +5 more
doaj +1 more source
Development of a fluorogenic ADAMTS-7 substrate
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The extracellular protease ADAMTS-7 has been identified as a potential therapeutic target in atherosclerosis and associated diseases such as coronary artery disease (CAD). However, ADAMTS-7 inhibitors have not been reported so far.
Salvatore Santamaria +10 more
doaj +1 more source
Orthopaedic Journal of Sports Medicine, 2021 Objectives: Intra-articular hematoma are caused by articular injury such as ligament rupture or intra-articular fracture and following knee surgery. It has been reported that intra-articular hematoma leads to cartilage degeneration. Exposure of articular
Takuya Tajima MD, PhD +4 more
doaj +1 more source
Effect of Dexamethasone on Cartilage Degeneration in Rats with Collagen-induced Arthritis
Shiyan dongwu yu bijiao yixue, 2022 ObjectiveTo establish a rat model of collagen-induced arthritis (CIA), a rat model of rheumatoid arthritis, and to study the protective effect of dexamethasone (DEX) on cartilage in CIA rats.MethodsThirty Wistar rats were randomly divided into three ...
XU Bingxin +3 more
doaj +1 more source
ADAMTS-5: The story so far [PDF]
European Cells & Materials, 2008 The recent discovery of ADAMTS-5 as the major aggrecanase in mouse cartilage came as a surprise. A great deal of research had focused on ADAMTS-4 and much less was known about the regulation, expression and activity of ADAMTS-5. Two years on, it is still
A J Fosang +3 more
doaj