Results 11 to 20 of about 11,949 (172)

ADAMTS-4 as cardiovascular biological marker in atherosclerosis (literature review)

Consilium Medicum
Cardiovascular diseases are a serious problem for medicine, society and economy all over the world. Currently, there is an active search for new biological markers and therapeutic targets in order to develop effective approaches to risk stratification ...
Amina M. Alieva, Elena V. Reznik, Irina E. Bajkova, Natalia V. Teplova, Albina B. Sultangalieva, Elina Z. Etezova, Zhanna L. Rabaeva, Rugaya N. Imanova, Polina Yu. Boeva, Igor G. Nikitin   +9 more
doaj   +2 more sources

ADAMTS-4 as a possible distinguishing indicator between osteoarthritis and haemophilic arthropathy. [PDF]

Haemophilia, 2022
AbstractIntroductionOsteoarthritis (OA) and haemophilic arthropathy (HA) are clinically similar, but pathologically distinct conditions which result in joint pain and loss of function. Distinguishing their disease mechanisms is therefore a key step in the development of curative therapy, as opposed to current symptomatic treatments.
Kalebota N, Salai G, Peric P, Hrkac S, Novak R, Durmis KK, Grgurevic L.   +6 more
europepmc   +5 more sources

The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities [PDF]

Journal of Vascular Research, 2022
Extracellular matrix proteins are regulated by metzincin proteases, like the disintegrin metalloproteinases with thrombospondin motifs (ADAMTS) family members. This review focuses on the emerging role which ADAMTS-4 might play in vascular pathology, which has implications for atherosclerosis and vessel wall abnormalities, as well as for the resulting ...
Rudjer Novak, Stela Hrkac, Grgur Salai, Josko Bilandzic, Luka Mitar, Lovorka Grgurevic   +5 more
  +7 more sources

Depletion of aquaporin 1 decreased ADAMTS‑4 expression in human chondrocytes. [PDF]

Mol Med Rep, 2018
Inflammation serves an important role in the progression of osteoarthritis (OA), and IL‑1β may act as a catabolic factor on cartilage, reducing the synthesis of primary cartilage components type II collagen and aggrecan. Aquaporin 1 (AQP1) is a 28‑kDa water channel formed of six transmembrane domains on the cell membrane.
Haneda M, Hayashi S, Matsumoto T, Hashimoto S, Takayama K, Chinzei N, Kihara S, Takeuchi K, Nishida K, Kuroda R.   +9 more
europepmc   +4 more sources

ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. [PDF]

Osteoarthritis Cartilage, 2015
To evaluate the potential of ADAMTS-4 (aggrecanase -1) activity in synovial fluid (SF) as a biomarker of knee injury and joint disease.We have measured ADAMTS-4 activity in the synovial fluid of 170 orthopaedic patients with different degrees of joint pathology, using a commercial ADAMTS-4 fluorescence resonance energy transfer (FRET) substrate assay ...
Roberts S, Evans H, Wright K, van Niekerk L, Caterson B, Richardson JB, Kumar KH, Kuiper JH.   +7 more
europepmc   +6 more sources

Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. [PDF]

Sci Rep, 2017
AbstractSporadic aortic aneurysm and dissections (AADs) are common vascular diseases that carry a high mortality rate. ADAMTS-4 (a disintegrin-like and metalloproteinase with thrombospondin motifs-4) is a secreted proteinase involved in inflammation and matrix degradation. We previously showed ADAMTS-4 levels were increased in human sporadic descending
Ren P, Hughes M, Krishnamoorthy S, Zou S, Zhang L, Wu D, Zhang C, Curci JA, Coselli JS, Milewicz DM, LeMaire SA, Shen YH.   +11 more
europepmc   +4 more sources

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. [PDF]

Mol Neurodegener, 2016
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) proteoglycanases are specialized in the degradation of chondroitin sulfate proteoglycans and participate in mechanisms mediating neuroplasticity. Despite the beneficial effect of ADAMTS-4 on neurorepair after spinal cord injury, the functions of ADAMTS proteoglycanases in other CNS
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J.   +9 more
europepmc   +5 more sources

The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. [PDF]

PLoS ONE, 2015
The specific degradation of type II collagen and aggrecan by matrix metalloproteinase (MMP)-9, -13 and ADAMTS-4 and -5 (aggrecanase-1 and -2) in the cartilage matrix is a critical step in pathology of osteoarthritis (OA).
Yi He, Qinlong Zheng, MengMeng Jiang, Shu Sun, Thorbjørn G Christiansen, Moustapha Kassem, Morten A Karsdal, Anne C Bay-Jensen   +7 more
doaj   +1 more source

Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

Scientific Reports, 2021
ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA).
Salvatore Santamaria, Doretta Cuffaro, Elisa Nuti, Lidia Ciccone, Tiziano Tuccinardi, Francesca Liva, Felicia D’Andrea, Rens de Groot, Armando Rossello, Josefin Ahnström   +9 more
doaj   +1 more source

ADAMTS proteases in cardiovascular physiology and disease [PDF]

Open Biology, 2020
The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family comprises 19 proteases that regulate the structure and function of extracellular proteins in the extracellular matrix and blood.
Salvatore Santamaria, Rens de Groot
doaj   +1 more source