Results 31 to 40 of about 11,934 (162)

Structure analysis reveals the flexibility of the ADAMTS‐5 active site [PDF]

Protein Science, 2011
AbstractA ((1S,2R)‐2‐hydroxy‐2,3‐dihydro‐1H‐inden‐1‐yl) succinamide derivative (here referred to as Compound 12) shows significant activity toward many matrix metalloproteinases (MMPs), including MMP‐2, MMP‐8, MMP‐9, and MMP‐13. Modeling studies had predicted that this compound would not bind to ADAMTS‐5 (a disintegrin and metalloproteinase with ...
Huey-Sheng, Shieh, Alfredo G, Tomasselli, Karl J, Mathis, Mark E, Schnute, Scott S, Woodard, Nicole, Caspers, Jennifer M, Williams, James R, Kiefer, Grace, Munie, Arthur, Wittwer, Anne-Marie, Malfait, Micky D, Tortorella   +11 more
openaire   +2 more sources

Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway

Bone & Joint Research, 2021
Aims: Interleukin (IL)-1β is one of the major pathogenic regulators during the pathological development of intervertebral disc degeneration (IDD). However, effective treatment options for IDD are limited.
Zi-Miao Liu, Cheng-Chang Lu, Po-Chih Shen, Shih-Hsiang Chou, Chia-Lung Shih, Jian-Chih Chen, Yin Chun Tien   +6 more
doaj   +1 more source

ADAMTS‐5: A difficult teenager turning 20

International Journal of Experimental Pathology, 2020
SummaryA Disintegrin And Metalloproteinase with ThromboSpondin motif (ADAMTS)‐5 was identified in 1999 as one of the enzymes responsible for cleaving aggrecan, the major proteoglycan in articular cartilage. Studies in vitro, ex vivo and in vivo have validated ADAMTS‐5 as a target in osteoarthritis (OA), a disease characterized by extensive degradation ...
openaire   +5 more sources

Immune thrombotic thrombocytopenic purpura: Personalized therapy using ADAMTS‐13 activity and autoantibodies

Research and Practice in Thrombosis and Haemostasis, 2021
Recently, treatment of immune‐mediated thrombotic thrombocytopenic purpura (ITTP) has changed with the advent of caplacizumab in clinical practice.
Francesca Palandri, Christian Di Pietro, Francesca Ricci, Pier Luigi Tazzari, Vanda Randi, Daniela Bartoletti, Michele Cavo, Nicola Vianelli, Giuseppe Auteri   +8 more
doaj   +1 more source

Computational insights into the substrate recognition mechanism of cartilage extracellular matrix degradation

Computational and Structural Biotechnology Journal, 2021
Articular cartilage is connective tissue that forms a slippery load-bearing joint surface between bones. With outstanding mechanical properties, it plays an essential role in cushioning impact and protecting the ends of bones.
Yen-Yu Lai, Deng Li, Shu-Wei Chang
doaj   +1 more source

Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage

BMC Musculoskeletal Disorders, 2017
Background ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteins play an important pathological role in matrix degeneration. Aggrecan degradation is a significant and critical event in early-stage osteoarthritis. To determine the
Takuya Tajima, Tomohisa Sekimoto, Nami Yamaguchi, Noboru Taniguchi, Syuji Kurogi, Masugi Maruyama, Etsuo Chosa   +6 more
doaj   +1 more source

Effect of Dexamethasone on Cartilage Degeneration in Rats with Collagen-induced Arthritis

Shiyan dongwu yu bijiao yixue, 2022
ObjectiveTo establish a rat model of collagen-induced arthritis (CIA), a rat model of rheumatoid arthritis, and to study the protective effect of dexamethasone (DEX) on cartilage in CIA rats.MethodsThirty Wistar rats were randomly divided into three ...
XU Bingxin, FAN Kaijian, WANG Tingyu, CHEN Huijin   +3 more
doaj   +1 more source

Philogenetic Analysis of ADAMTS-4 and ADAMTS-5 Structures

Natural Systems and Resources, 2020
ADAMTS-4 and -5 are aggrecanases that are involved in the development of osteoarthrosis by breaking aggrecan at various binding sites, of which cleavage in the Glu373-Ala374 bond plays the most important role in pathogenesis. Therefore, studying them is an urgent task to this day. Now, the structural features of these enzymes have already been studied,
Anastasia Korchagina, Pavel Krylov
openaire   +1 more source

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1. [PDF]

MAbs, 2017
The potent aggrecanase ADAMTS-5 is constitutively secreted by chondrocytes, but it is rapidly endocytosed in normal cartilage via the cell surface endocytic receptor LRP1. Therefore it is difficult to detect the total ADAMTS-5 activity produced. In this study, we isolated a monoclonal anti-ADAMTS-5 antibody 1B7 that blocks LRP1-mediated internalization
Santamaria S, Fedorov O, McCafferty J, Murphy G, Dudhia J, Nagase H, Yamamoto K.   +6 more
europepmc   +7 more sources

Expression of ADAMTS-5 in deformed human temporomandibular joint discs.

Histology and histopathology, 2008
To study the expression of a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) in tissue samples of deformed human temporomandibular joint (TMJ) discs and cells obtained from the discs.Eleven adult human TMJ discs (nine diseased discs and two normal discs) were used in this study.
Matsumoto, Takashi, Tojyo, Itaru, Kiga, Norifumi, Hiraishi, Yukihiro, Fujita, Shigeyuki   +4 more
openaire   +3 more sources