Results 31 to 40 of about 12,658,346 (176)

Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis. [PDF]

Osteoarthritis Cartilage, 2016
Objective The primary goal of this study was to test the disease-modifying effect of blocking a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 with a neutralizing monoclonal antibody (mAb) starting 4 weeks after destabilization ...
Miller RE, Tran PB, Ishihara S, Larkin J, Malfait AM.   +4 more
europepmc   +2 more sources

Daratumumab for relapsed refractory immune thrombotic thrombocytopenic purpura: initial response and long-term follow-up [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Management of patients with refractory or frequently relapsing (r/r) immune thrombotic thrombocytopenic purpura (iTTP) remains challenging, with no established consensus on optimal therapeutic strategies.
Roman Schimmer, Jana van den Berg, Marissa Schraner, Alice Trinchero, Andreas Holbro, Johanna A. Kremer Hovinga, Jan-Dirk Studt   +6 more
doaj   +2 more sources

Proteolytic Activities of Human ADAMTS-5 [PDF]

Journal of Biological Chemistry, 2007
Aggrecanases have been characterized as proteinases that cleave the Glu373-Ala374 bond of the aggrecan core protein, and they are multidomain metalloproteinases belonging to the ADAMTS (adamalysin with thrombospondin type 1 motifs) family. The first aggrecanases discovered were ADAMTS-4 (aggrecanase 1) and ADAMTS-5 (aggrecanase 2).
Christi Gendron, Masahide Kashiwagi, Ngee Han Lim, Jan J. Enghild, Ida B. Thøgersen, Clare Hughes, Bruce Caterson, Hideaki Nagase   +7 more
openaire   +4 more sources

ADAMTS proteoglycanases downregulation with impaired oocyte quality in PCOS

Archives of Endocrinology and Metabolism, 2021
Objective: A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) and ADAMTS-5 normal expression levels are essential for ovulation and subsequent fertilization.
Sepide Gohari taban, Iraj Amiri, Massoud Saidijam, Sara Soleimani asl, Mahnaz Yavangi, Elham Khanlarzadeh, Nooshin Mohammadpour, Tayebe Artimani   +7 more
doaj   +1 more source

Expression and activity of ADAMTS‐5 in synovium [PDF]

European Journal of Biochemistry, 2001
ADAMTS proteinases, belonging to the adamalysin subfamily of metalloproteinases, have been implicated in a variety of cellular events such as morphogenesis, cell migration, angiogenesis, ovulation and extracellular matrix breakdown. Aggrecanase‐1 (ADAMTS‐4) and aggrecanase‐2 (ADAMTS‐5) have been identified in cartilage and are largely responsible for ...
Vankemmelbeke, Mireille N., Maki, Richard A., Buttle, D. J., Liu, Changlu., Burnett, David., Holen, I., Wilson, Anthony G., Ilic, Mirna Zlokovic., Handley, Christopher John., Kelner, Gregory S., Clark, Melody.   +10 more
openaire   +2 more sources

Association of ADAMTS proteoglycanases downregulation with IVF-ET outcomes in patients with polycystic ovary syndrome: a systematic review and meta-analysis

Reproductive Biology and Endocrinology, 2022
Background A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) is involved in inflammation and fertility in women with polycystic ovary syndrome (PCOS).
Yanbin Shi, Yang Shi, Guiyuan He, Guang Wang, Hongbo Liu, Xiaoguang Shao   +5 more
doaj   +1 more source

Evaluation of S201086/GLPG1972, an ADAMTS-5 inhibitor, for the treatment of knee osteoarthritis in ROCCELLA: a phase 2 randomized clinical trial.

Osteoarthritis and Cartilage, 2023
OBJECTIVE To evaluate the efficacy and safety of the anti-catabolic ADAMTS-5 inhibitor S201086/GLPG1972 for the treatment of symptomatic knee osteoarthritis. DESIGN ROCCELLA (NCT03595618) was a randomized, double-blind, placebo-controlled, dose-ranging,
T. Schnitzer, M. Pueyo, H. Deckx, E. M. van der Aar, K. Bernard, S. Hatch, M. V. D. van der Stoep, S. Grankov, D. Phung, O. Imbert, D. Chimits, K. Muller, M. Hochberg, H. Bliddal, W. Wirth, F. Eckstein, P. Conaghan   +16 more
semanticscholar   +1 more source

Unlocking ADAMTS-5: <i>In Silico</i> insights into TMJ proteomics and docking dynamics. [PDF]

J Orthod Sci
BACKGROUND: Temporomandibular joint (TMJ) disorder refers to a condition involving dysfunction or pain in the jaw joint and the muscles that control jaw movement. It can affect one or both sides of the jaw and can cause various symptoms, including Jaw pain or tenderness; Difficulty or discomfort when chewing; Clicking, popping,
Divakar A, Kandasamy N, Varghese RM, Jeyachandran S, Thomas LR.   +4 more
europepmc   +4 more sources

Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy

Molecules, 2022
We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan substrates versican and biglycan in an ocular microenvironment of proliferative diabetic ...
Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Eef Allegaert, Mohammad Mairaj Siddiquei, Ajmal Ahmad, Priscilla Gikandi, Gert De Hertogh, Ghislain Opdenakker   +7 more
doaj   +1 more source

Molecular analyses of ADAMTS-1, -4, -5, and IL-17 a cytokine relationship in patients with ulcerative colitis

BMC Gastroenterology, 2023
Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease that develops due to the impaired immune response in genetically susceptible individuals, and its etiopathogenesis is not fully elucidated.
Tahir Buran, Muhammet Burak Batır, Fethi Sırrı Çam, Elmas Kasap, Fatih Çöllü, Hamide Betül Gerik Çelebi, Mustafa Şahin   +6 more
doaj   +1 more source