In Silico Insights into the Inhibition of ADAMTS-5 by Punicalagin and Ellagic Acid for the Treatment of Osteoarthritis. [PDF]
Int J Mol SciADAMTS-5 (aggrecanase-2) is a major metalloprotease involved in regulating the cartilage extracellular matrix. Due to its role in removing aggrecan in the progression of osteoarthritis (OA), ADAMTS-5 is often regarded as a potential therapeutic target ...
Breland AN +3 more
europepmc +4 more sources
Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix Remodeling. [PDF]
Arterioscler Thromb Vasc Biol, 2018 Objective— Thoracic aortic aneurysm (TAA), a degenerative disease of the aortic wall, is accompanied by changes in the structure and composition of the aortic ECM (extracellular matrix). The ADAMTS (a disintegrin and metalloproteinase with thrombospondin
Fava M +12 more
europepmc +6 more sources
Matrilin-2 Is Proteolytically Cleaved by ADAMTS-4 and ADAMTS-5 [PDF]
Molecules, 2014 Matrilin-2 is a widely distributed, oligomeric extracellular matrix protein that forms a filamentous network by binding to a variety of different extracellular matrix proteins.
Zhengke Wang +3 more
doaj +5 more sources
Cangxitongbi capsule protects articular cartilage of the knee in rats by regulating ADAMTS-5. [PDF]
Ann Transl Med, 2020 Background Knee osteoarthritis (KOA) is a disease with a high incidence in elderly patients and traditional Chinese medicine has a significant effect on the treatment of KOA. Cangxitongbi capsule (CXTB) is a traditional Chinese medicine for KOA treatment
Song XY, Xie WP, Zhang P, Zhao M, Bi RX.
europepmc +5 more sources
Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2). [PDF]
Biochem J, 2015 We isolated four antibody-based exosite inhibitors of adamalysin-like metalloproteinases with thrombospondin (TS) motifs (ADAMTS)-5, a multi-domain metalloproteinase, from a phage display library.
Santamaria S +7 more
europepmc +6 more sources
Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1. [PDF]
MAbs, 2017 The potent aggrecanase ADAMTS-5 is constitutively secreted by chondrocytes, but it is rapidly endocytosed in normal cartilage via the cell surface endocytic receptor LRP1. Therefore it is difficult to detect the total ADAMTS-5 activity produced.
Santamaria S +6 more
europepmc +8 more sources
Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS-5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip. [PDF]
Clin Pharmacol Drug Dev, 2022 GLPG1972/S201086 is a disintegrin and metalloproteinase with thrombospondin motif‐5 (ADAMTS‐5) inhibitor in development as an osteoarthritis disease‐modifying therapy.
van der Aar E +11 more
europepmc +2 more sources
The design of a randomized, placebo-controlled, dose-ranging trial to investigate the efficacy and safety of the ADAMTS-5 inhibitor S201086/GLPG1972 in knee osteoarthritis. [PDF]
Osteoarthr Cartil Open, 2021 Objective This study aims to assess the efficacy of the anticatabolic ‘a disintegrin and metalloproteinase with thrombospondin motif-5’ (ADAMTS-5) inhibitor, S201086/GLPG1972, in slowing cartilage loss in participants with knee osteoarthritis (OA ...
Imbert O +9 more
europepmc +2 more sources
Feprazone Ameliorates TNF-α-Induced Loss of Aggrecan via Inhibition of the SOX-4/ADAMTS-5 Signaling Pathway. [PDF]
ACS Omega, 2021 Background: Arthritis is a cartilage degenerative disease that is mainly induced by the degradation of the cartilage extracellular matrix (ECM), which is found to be regulated by the expression level of a disintegrin and metalloproteinase with ...
Xiong X +6 more
europepmc +2 more sources
The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo. [PDF]
Int J Mol Sci, 2020 Osteoarthritis (OA) is associated with cartilage breakdown, brought about by ADAMTS-5 mediated aggrecan degradation followed by MMP-derived aggrecan and type II collagen degradation.
Siebuhr AS +8 more
europepmc +2 more sources