Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide [PDF]
Scientific Reports, 2021 ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA).
Salvatore Santamaria +9 more
doaj +9 more sources
Inhibition of SMAD3 effectively reduces ADAMTS-5 expression in the early stages of osteoarthritis [PDF]
BMC Musculoskeletal Disorders, 2023 Objective As one of the most important protein-degrading enzymes, ADAMTS-5 plays an important role in the regulation of cartilage homeostasis, while miRNA-140 is specifically expressed in cartilage, which can inhibit the expression of ADAMTS-5 and delay ...
Wei Xiang +5 more
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Matrilin-2 Is Proteolytically Cleaved by ADAMTS-4 and ADAMTS-5 [PDF]
Molecules, 2014 Matrilin-2 is a widely distributed, oligomeric extracellular matrix protein that forms a filamentous network by binding to a variety of different extracellular matrix proteins.
Zhengke Wang +3 more
doaj +5 more sources
ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis [PDF]
Frontiers in Cardiovascular Medicine, 2020 Background: Acute aortic dissection (AAD) is associated with degeneration of the aortic media and accompanied by vascular extracellular matrix (ECM) remodeling.
Tao Zeng +10 more
doaj +2 more sources
ADAMTS-1, ADAMTS-5 and ADAMTS-13 are considered potential targets in the treatment of frozen shoulder [PDF]
Journal of Orthopaedic Surgery and ResearchBackground Frozen shoulder (FS) is a condition that causes shoulder pain and restricted movement, primarily due to inflammation, fibrosis, and adhesion of the shoulder joint capsule. It commonly affects individuals aged 30 to 60 years.
Zihao Zhou, Guanhong Chen
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Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles [PDF]
Biomolecules, 2020 Aberrant extracellular matrix synthesis and remodeling contributes to muscle degeneration and weakness in Duchenne muscular dystrophy (DMD). ADAMTS-5, a secreted metalloproteinase with catalytic activity against versican, is implicated in myogenesis and ...
Alex B. Addinsall +7 more
doaj +2 more sources
ADAMTS-5: The story so far [PDF]
European Cells & Materials, 2008 The recent discovery of ADAMTS-5 as the major aggrecanase in mouse cartilage came as a surprise. A great deal of research had focused on ADAMTS-4 and much less was known about the regulation, expression and activity of ADAMTS-5. Two years on, it is still
A J Fosang +3 more
doaj +3 more sources
Serum biomarkers reflecting progression of knee osteoarthritis: a stage-based evaluation of TGF-β3, ADAMTS-4, ADAMTS-5, and MMP-13 [PDF]
BMC Musculoskeletal DisordersBackground Knee osteoarthritis (KOA) is a progressive degenerative joint disease characterized by extracellular matrix (ECM) degradation and dysregulated inflammatory signaling.
Omer Esmez +3 more
doaj +2 more sources
The Relationship Between ADAMTS‐4 and ADAMTS‐5 Enzyme Levels in Patients With Degenerative Disc Disease: A Prospective Biochemical Study [PDF]
JOR SpineStudy Design Prospective biochemical study of comparison of A Disintegrin and Metalloproteinase with Thrombospondin motifs‐4 (ADAMTS‐4) and A Disintegrin and Metalloproteinase with Thrombospondin motifs 5 (ADAMTS5) levels in preoperative and ...
Cansu Tuncer +9 more
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Computational Insights into Flavonoids for ADAMTS-5 Exosite Inhibition in Knee Osteoarthritis: Docking, MD Simulations, and Machine Learning-Guided Structure Prediction [PDF]
MoleculesThe limited selectivity of most catalytic-site ADAMTS-5 inhibitors and the necessity to preserve aggrecan integrity in early-grade knee osteoarthritis require the development of selective aggrecanase inhibitors.
Mayurakkhi Bhatia +2 more
doaj +2 more sources