Results 61 to 70 of about 11,934 (162)

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2) [PDF]

Journal of Biological Chemistry, 2008
Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan.
Huey-Sheng, Shieh, Karl J, Mathis, Jennifer M, Williams, Robert L, Hills, Joe F, Wiese, Timothy E, Benson, James R, Kiefer, Margaret H, Marino, Jeffery N, Carroll, Joseph W, Leone, Anne-Marie, Malfait, Elizabeth C, Arner, Micky D, Tortorella, Alfredo, Tomasselli   +13 more
openaire   +2 more sources

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities [PDF]

Journal of Molecular Medicine, 2011
A disintegrin and metalloprotease with thrombospondin domains (ADAMTS)-4 (aggrecanase-1) and ADAMTS-5 (aggrecanase-2) are metalloproteases involved in articular cartilage degradation and represent potential therapeutic targets in arthritis treatment.
Moncada Pazos, Ángela, Obaya González, Álvaro Jesús, Gutiérrez Viloria, Cristina, López Otín, Carlos, Cal Miguel, Santiago Jesús   +4 more
openaire   +3 more sources

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Histopathologic Analysis of the Morpho‐Functional Zones of the Human Acetabular Labrum

Clinical Anatomy, Volume 39, Issue 7, Page 787-800, October 2026.
ABSTRACT The structural and functional adaptation of soft tissues to mechanical load controls their ability to withstand injury and influences their capacity for healing. Similar to the knee meniscus, the acetabular labrum exhibits zonal differences in mechanical load distribution, resulting in distinct regions with unique structural and functional ...
Abdulaziz A. Alomiery, Andrew C. Hall, Thomas H. Gillingwater, Afaf Alsolami, Abduelmenem Alashkham   +4 more
wiley   +1 more source

Early Intervention Strategies For Acute Cartilage Injury

Orthopaedic Journal of Sports Medicine, 2015
Objectives: Traumatic injury to cartilage has been shown to lead to Post-Traumatic Osteoarthritis (PTOA). The acute phase of PTOA is characterized with increased expression of aggrecanases and inflammatory cytokines in the injured cartilage.
Amaris Genemaras B.S., Chun-Yuh Charles Huang PhD, Lee D. Kaplan MD   +2 more
doaj   +1 more source

Expression of COL6A1 in Tumor Matrix of Cholangiocarcinoma and Its Mechanism of Tumor Progression

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Cholangiocarcinoma (CCA), a malignant tumor originating from the bile duct epithelial cells, is characterized by aggressive invasion and poor prognosis. Abnormal remodeling of the tumor microenvironment plays a pivotal role in its disease progression.
Weibin Zhang, Chongshi Gao, Chongzhou Lan, Jia Dong, Boxing Xu, Yingmei Li, Jin Dai, Baitong Che, Cheng Li, Gang Dong, Yunfei Wu, Bo Li, Cheng Yang, Lingmei Kong   +13 more
wiley   +1 more source

Juglanin inhibits IL-1β-induced inflammation in human chondrocytes

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Osteoarthritis (OA) is one of the most characterized joint diseases associated with chondrocyte apoptosis. Juglanin has been reported to have anti-inflammation activity. This study aimed to evaluate the protective anti-inflammatory effects of juglanin in
Xinxin Chen, Chengyong Zhang, Xiao Wang, Shousong Huo   +3 more
doaj   +1 more source