Results 81 to 90 of about 11,934 (162)

Circulating ADAMTS-12 levels in early- and late-onset severe preeclampsia

Medicine Science, 2016
Aim of this study is to determine whether maternal serum ADAMTS-12 levels differ among early-onset ( [Med-Science 2016; 5(3.000): 785-9]
Ayse Kirbas, Korkut Daglar, Hakan Timur, Zehra Yilmaz, Gulenay Gencosmanoglu, Nuri Danisman   +5 more
doaj   +1 more source

Monitoring ADAMTS-13 conformation in immune-mediated thrombotic thrombocytopenic purpura: toward personalized management

Research and Practice in Thrombosis and Haemostasis
Background: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy caused by an autoimmune-driven deficiency of ADAMTS-13.
Bérangère S. Joly, Elien Roose, Charlotte Dekimpe, Karen Vanhoorelbeke, Agnès Veyradier, Paul Coppo   +5 more
doaj   +1 more source

Splenectomy in relapsing and plasma-refractory acquired thrombotic thrombocytopenic purpura

Haematologica, 2004
BACKGROUND AND OBJECTIVES: Acquired thrombotic thrombocytopenic purpura (TTP) is often due to autoantibodies inhibiting ADAMTS-13 activity resulting in impaired processing of very large von Willebrand factor multimers.
JA Kremer Hovinga, JD Studt, F Demarmels Biasiutti, M Solenthaler, L Alberio, C Zwicky, S Fontana, BM Taleghani, A Tobler, B Laemmle   +9 more
doaj  

Correction: Inhibition of SMAD3 effectively reduces ADAMTS‑5 expression in the early stages of osteoarthritis. [PDF]

BMC Musculoskelet Disord, 2023
Xiang W, Wang C, Zhu Z, Wang D, Qiu Z, Wang W.   +5 more
europepmc   +1 more source

ADAMTS-5 degraded cartilage increases tissue turnover in synovial membrane explants and stimulation is inhibited by the anti ADAMTS-5 nanobody, M6495 [PDF]

Osteoarthritis and Cartilage, 2020
N. Sharma, A.-C. Bay-Jensen, H.S. Hector, T. Gantzel, M. Michaelis, C. Ladel, M.A. Karsdal, S. Lindemann, C.S. Thudium   +8 more
openaire   +1 more source

Structure, substrate recognition and therapeutic targeting of the human ADAMTS-5 spacer domain

Acta Crystallographica Section D Structural Biology
The ADAMTS (a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs) family of secreted metalloproteinases plays essential roles in extracellular matrix remodeling. ADAMTS-5 contributes to cartilage degradation, cleaving proteoglycans such as aggrecan and versican, and being involved in both physiological tissue turnover and ...
Mario Milani, Michela Visintin, Ivet Krastanova, Marco Visentini, Elisa Margotti, Gabriele Ugolini, Martino Bolognesi, Lucio C. Rovati, Eloise Mastrangelo   +8 more
openaire   +2 more sources

Association of polymorphisms in ADAMTS-5 gene with the susceptibility to knee osteoarthritis: A protocol for systematic review and meta-analysis. [PDF]

Medicine (Baltimore), 2021
Deng T, Zhou Y, Zhang K, Dong Z, Zhang J, Lv X, Song S, Ma Y.   +7 more
europepmc   +1 more source

The anti-ADAMTS-5 nanobody®, M6495, inhibits the activation of TLR by ADAMTS-5-mediated degradation fragments in cartilage explants [PDF]

Osteoarthritis and Cartilage, 2019
N. Sharma, P. Drobinski, M. Karsdal, A.-C. Bay-Jensen, C. Thudium, M. Michaelis, C. Ladel, S. Lindemann   +7 more
openaire   +1 more source

Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS-5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip. [PDF]

Clin Pharmacol Drug Dev, 2022
van der Aar E, Deckx H, Dupont S, Fieuw A, Delage S, Larsson S, Struglics A, Lohmander LS, Lalande A, Leroux E, Amantini D, Passier P.   +11 more
europepmc   +1 more source

Poster 204: A Possible Cause of Articular Cartilage Degeneration in the Acute Phase after Anterior Cruciate Ligament Reconstruction

Orthopaedic Journal of Sports Medicine
Objectives: Intra-articular hemarthrosis contributes to the expression of various cytokines in articular injuries of knees. Exposure of articular cartilage to blood has been confirmed to induce irreversible cartilage damage.
Yudai Morita MD, Takuya Tajima MD, PhD, Nami Yamaguchi, Takuji Yokoe, Etsuo Chosa   +4 more
doaj   +1 more source