Results 101 to 110 of about 12,658,346 (176)

ADAMTS-5 degraded cartilage increases tissue turnover in synovial membrane explants and stimulation is inhibited by the anti ADAMTS-5 nanobody, M6495 [PDF]

Osteoarthritis and Cartilage, 2020
N. Sharma, A.-C. Bay-Jensen, H.S. Hector, T. Gantzel, M. Michaelis, C. Ladel, M.A. Karsdal, S. Lindemann, C.S. Thudium   +8 more
openaire   +1 more source

Structure, substrate recognition and therapeutic targeting of the human ADAMTS-5 spacer domain

Acta Crystallographica Section D Structural Biology
The ADAMTS (a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs) family of secreted metalloproteinases plays essential roles in extracellular matrix remodeling. ADAMTS-5 contributes to cartilage degradation, cleaving proteoglycans such as aggrecan and versican, and being involved in both physiological tissue turnover and ...
Mario Milani, Michela Visintin, Ivet Krastanova, Marco Visentini, Elisa Margotti, Gabriele Ugolini, Martino Bolognesi, Lucio C. Rovati, Eloise Mastrangelo   +8 more
openaire   +2 more sources

Association of polymorphisms in ADAMTS-5 gene with the susceptibility to knee osteoarthritis: A protocol for systematic review and meta-analysis. [PDF]

Medicine (Baltimore), 2021
Deng T, Zhou Y, Zhang K, Dong Z, Zhang J, Lv X, Song S, Ma Y.   +7 more
europepmc   +1 more source

The anti-ADAMTS-5 nanobody®, M6495, inhibits the activation of TLR by ADAMTS-5-mediated degradation fragments in cartilage explants [PDF]

Osteoarthritis and Cartilage, 2019
N. Sharma, P. Drobinski, M. Karsdal, A.-C. Bay-Jensen, C. Thudium, M. Michaelis, C. Ladel, S. Lindemann   +7 more
openaire   +1 more source

Poster 204: A Possible Cause of Articular Cartilage Degeneration in the Acute Phase after Anterior Cruciate Ligament Reconstruction

Orthopaedic Journal of Sports Medicine
Objectives: Intra-articular hemarthrosis contributes to the expression of various cytokines in articular injuries of knees. Exposure of articular cartilage to blood has been confirmed to induce irreversible cartilage damage.
Yudai Morita MD, Takuya Tajima MD, PhD, Nami Yamaguchi, Takuji Yokoe, Etsuo Chosa   +4 more
doaj   +1 more source

A CASE OF THROMBOTIC THROMBOCYTOPENIC PURPURA RELATED TO MALIGNITY AND CHEMOTHERAPY

Hematology, Transfusion and Cell Therapy
Objective: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening multisystem disease. TTP progresses with Microangiopathic hemolytic anemia (MAHA), fever, thrombocytopenia, neurological symptoms, and renal failure.
Ebru Kavak Yavuz, Songül Beskisiz Dönen, Etem Özkaya, Esra Pirinççi, Abdullah Karakuş, Orhan Ayyıldız   +5 more
doaj   +1 more source

Differential effects of alendronate on chondrocytes, cartilage matrix and subchondral bone structure in surgically induced osteoarthritis in mice

Scientific Reports
Bisphosphonates (BP) are considered a treatment option for osteoarthritis (OA) due to reduction of OA-induced microtrauma in the bone marrow, stabilization of subchondral bone (SB) layer and pain reduction.
Marianne Ehrnsperger, Shahed Taheri, Patrick Pann, Arndt F. Schilling, Susanne Grässel   +4 more
doaj   +1 more source

Immune thrombotic thrombocytopenic purpura and diabetic ketoacidosis: a case report and literature review

Thrombosis Journal
Background Thrombotic thrombocytopenic purpura (TTP) is an uncommon and life-threatening disorder caused by a deficiency of ADAMTS-13, and eventually leads to microangiopathic hemolytic anemia, severe thrombocytopenia, and organ damages. Acute TTP events
Geng-Hao Bai, Mei-Hwa Lin, Yu-Pei Chen, Tien-Jyun Chang, Sheng-Chieh Chou   +4 more
doaj   +1 more source

In vitro characterization of the ADAMTS-5 specific nanobody® M6495 [PDF]

Osteoarthritis and Cartilage, 2018
D. Werkmann, M.-A. Buyse, L. Dejager, S. Cornelis, C.S. Thudium, M.A. Karsdal, C. Ladel, H. Guehring, M. Michaelis, S. Lindemann   +9 more
openaire   +1 more source

Mitochondrial dysfunction activates ADAMTS-5 expression via mt-dsRNA-PKR-Spi-1 axis in osteoarthritic chondrocytes. [PDF]

iScience
Mu Y, Yan S, Wang Y, Liang B, Tang R, Yang H, Ma L, Zhang Y, Li D.   +8 more
europepmc   +1 more source