Results 91 to 100 of about 11,934 (162)

Feprazone Ameliorates TNF-α-Induced Loss of Aggrecan via Inhibition of the SOX-4/ADAMTS-5 Signaling Pathway. [PDF]

ACS Omega, 2021
Xiong X, Liu L, Xu F, Wu X, Yin Z, Dong Y, Qian P.   +6 more
europepmc   +1 more source

The design of a randomized, placebo-controlled, dose-ranging trial to investigate the efficacy and safety of the ADAMTS-5 inhibitor S201086/GLPG1972 in knee osteoarthritis. [PDF]

Osteoarthr Cartil Open, 2021
Imbert O, Deckx H, Bernard K, van der Aar E, Pueyo M, Saeed N, Fuerst T, Wirth W, Conaghan PG, Eckstein F.   +9 more
europepmc   +1 more source

A CASE OF THROMBOTIC THROMBOCYTOPENIC PURPURA RELATED TO MALIGNITY AND CHEMOTHERAPY

Hematology, Transfusion and Cell Therapy
Objective: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening multisystem disease. TTP progresses with Microangiopathic hemolytic anemia (MAHA), fever, thrombocytopenia, neurological symptoms, and renal failure.
Ebru Kavak Yavuz, Songül Beskisiz Dönen, Etem Özkaya, Esra Pirinççi, Abdullah Karakuş, Orhan Ayyıldız   +5 more
doaj   +1 more source

Differential effects of alendronate on chondrocytes, cartilage matrix and subchondral bone structure in surgically induced osteoarthritis in mice

Scientific Reports
Bisphosphonates (BP) are considered a treatment option for osteoarthritis (OA) due to reduction of OA-induced microtrauma in the bone marrow, stabilization of subchondral bone (SB) layer and pain reduction.
Marianne Ehrnsperger, Shahed Taheri, Patrick Pann, Arndt F. Schilling, Susanne Grässel   +4 more
doaj   +1 more source

The Anti-ADAMTS-5 Nanobody^® M6495 Protects Cartilage Degradation Ex Vivo. [PDF]

Int J Mol Sci, 2020
Siebuhr AS, Werkmann D, Bay-Jensen AC, Thudium CS, Karsdal MA, Serruys B, Ladel C, Michaelis M, Lindemann S.   +8 more
europepmc   +1 more source

Immune thrombotic thrombocytopenic purpura and diabetic ketoacidosis: a case report and literature review

Thrombosis Journal
Background Thrombotic thrombocytopenic purpura (TTP) is an uncommon and life-threatening disorder caused by a deficiency of ADAMTS-13, and eventually leads to microangiopathic hemolytic anemia, severe thrombocytopenia, and organ damages. Acute TTP events
Geng-Hao Bai, Mei-Hwa Lin, Yu-Pei Chen, Tien-Jyun Chang, Sheng-Chieh Chou   +4 more
doaj   +1 more source

In vitro characterization of the ADAMTS-5 specific nanobody® M6495 [PDF]

Osteoarthritis and Cartilage, 2018
D. Werkmann, M.-A. Buyse, L. Dejager, S. Cornelis, C.S. Thudium, M.A. Karsdal, C. Ladel, H. Guehring, M. Michaelis, S. Lindemann   +9 more
openaire   +1 more source

Early mRNA expression of pro-inflammatory cytokines and ADAMTS-5 in an acute ischemia/reperfusion-induced pressure ulcer model, a pilot exploratory animal study. [PDF]

Turk J Phys Med Rehabil
Sağlam M, Yanık B, Erdoğan E, Yaşar ZS, Cemeroğlu Ö, Bakan B, Çakırbay H.   +6 more
europepmc   +1 more source

Mitochondrial dysfunction activates ADAMTS-5 expression via mt-dsRNA-PKR-Spi-1 axis in osteoarthritic chondrocytes. [PDF]

iScience
Mu Y, Yan S, Wang Y, Liang B, Tang R, Yang H, Ma L, Zhang Y, Li D.   +8 more
europepmc   +1 more source

P129 | Diagnostic pathway for thrombotic thrombocytopenic purpura: Case study

Italian Journal of Medicine
Premises: TTP is characterized by MAHA with thrombocytopenia and organ ischemia. The diagnosis is confirmed by a severe deficiency in ADAMTS 13 activity, either congenital or immune-mediated.
doaj   +1 more source