Results 91 to 100 of about 12,658,346 (176)

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, Volume 13, Issue 48, 28 August 2026.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

Functional evolution of ADAMTS genes: Evidence from analyses of phylogeny and gene organization

BMC Evolutionary Biology, 2005
Background The ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) proteins are a family of metalloproteases with sequence similarity to the ADAM proteases, that contain the thrombospondin type 1 sequence repeat motifs (TSRs ...
Van Meir Erwin G, Logsdon John M, Malik Shehre-Banoo, Nicholson Ainsley C   +3 more
doaj   +1 more source

Lycorine Suppresses Endplate-Chondrocyte Degeneration and Prevents Intervertebral Disc Degeneration by Inhibiting NF-κB Signalling Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cartilaginous endplate (CEP) degeneration is an important cause for intervertebral disc (IVD) degeneration that leads to low-back pain.
Gangliang Wang, Kangmao Huang, Yangxin Dong, Shuai Chen, Jianfeng Zhang, Jiying Wang, Ziang Xie, Xianfeng Lin, Xiangqiang Fang, Shunwu Fan   +9 more
doaj   +1 more source

Von Willebrand Factor Antigen Predicts Response to Double Dose of Aspirin and Clopidogrel by PFA-100 in Patients Undergoing Primary Angioplasty for St Elevation Myocardial Infarction

The Scientific World Journal, 2013
Von Willebrand factor (VWF) is an emerging risk factor in acute coronary syndromes. Platelet Function Analyzer (PFA-100) with Collagen/Epinephrine (CEPI) is sensitive to functional alterations of VWF and also identifies patients with high on-treatment ...
Jacopo Gianetti, Maria Serena Parri, Francesca Della Pina, Federica Marchi, Endrin Koni, Alberto De Caterina, Stefano Maffei, Sergio Berti   +7 more
doaj   +1 more source

Dehydroepiandrosterone inhibits ADAMTS expression via an ERK-dependent mechanism in chondrocytes.

PLoS ONE
Osteoarthritis (OA) is a joint disease in which cartilage degradation is the hallmark pathological change. In this study, we investigated the anti-osteoarthritic effects of DHEA in rabbit chondrocytes.
Kai Huang, Lin Cheng, Cheng Jiang, Chunwei Zheng, Haili Cai   +4 more
doaj   +1 more source

Congenital Thrombotic Thrombocytopenic Purpura: Atypical Presentation And First ADAMTS 13 Mutation In A Tunisian Child

Mediterranean Journal of Hematology and Infectious Diseases, 2013
Background: Congenital deficiency of ADAMTS13 is characterized by systemic platelet clumping, hemolytic anemia and multiorgan failure. Although, more than 100 mutations have been reported, atypical clinical presentation may be involved in diagnostic ...
aida borgi
doaj   +1 more source

A comparative study of anti–ADAMTS-13 antibody dynamics in immune-mediated thrombotic thrombocytopenic purpura

Research and Practice in Thrombosis and Haemostasis
Background: Thrombotic thrombocytopenic purpura, particularly its immune-mediated variant (iTTP), necessitates accurate diagnostic approaches for effective management.
Maria Rita Cozzi, Fabio Del Ben, Chiara Corso, Agostino Steffan   +3 more
doaj   +1 more source

Circulating ADAMTS-12 levels in early- and late-onset severe preeclampsia

Medicine Science, 2016
Aim of this study is to determine whether maternal serum ADAMTS-12 levels differ among early-onset ( [Med-Science 2016; 5(3.000): 785-9]
Ayse Kirbas, Korkut Daglar, Hakan Timur, Zehra Yilmaz, Gulenay Gencosmanoglu, Nuri Danisman   +5 more
doaj   +1 more source

Monitoring ADAMTS-13 conformation in immune-mediated thrombotic thrombocytopenic purpura: toward personalized management

Research and Practice in Thrombosis and Haemostasis
Background: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy caused by an autoimmune-driven deficiency of ADAMTS-13.
Bérangère S. Joly, Elien Roose, Charlotte Dekimpe, Karen Vanhoorelbeke, Agnès Veyradier, Paul Coppo   +5 more
doaj   +1 more source

Correction: Inhibition of SMAD3 effectively reduces ADAMTS‑5 expression in the early stages of osteoarthritis. [PDF]

BMC Musculoskelet Disord, 2023
Xiang W, Wang C, Zhu Z, Wang D, Qiu Z, Wang W.   +5 more
europepmc   +1 more source