Results 21 to 30 of about 15,848 (207)

Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis

Biotechnic & Histochemistry, 2022
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are metalloproteinases that bind to components of the extracellular matrix (ECM) to regulate tissue remodeling and homeostasis. ADAMTS can be inhibited by tissue inhibitors of metalloproteinases (TIMPs). Expression of ADAMTS increases under inflammatory conditions.
M. Ayşe Tayman, İsmail Koyuncu
openaire   +4 more sources

Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction [PDF]

, 2022
Background: Prolonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown.
Roger Preston (7896068), Niall Conlon (8412573), Jean Dunne (9617409), Ross I Baker (11140107), Ignacio Martín-Loeches (10147457), Mary Gardiner (325055), Liam Townsend (9617403), Gerard Curley (7897901), Mary Byrne (10715766), Rachel Kiersey (7898339), Cliona Ni Cheallaigh (10899906), Colm Bergin (277802), Patrick W Mallon (11140104), Aifric Naughton (10762248), Ciaran Bannan (4164424), Jamie O'Sullivan (7895630), Stephanie Elliott (10124057), James O'Donnell (7895615), Irish COVID-19 Vasculopathy Study (iCVS) Investigators (13154722), Soracha E Ward (10899468), Ellie Karampini (8712483), Parthiban Nadarajan (160272), Helen Fogarty (7899788), Aisling Rehill (7896929)   +23 more
core   +3 more sources

The ADAMTS metalloproteinases [PDF]

Biochemical Journal, 2005
The ADAMTSs (adisintegrin and metalloproteinase with thrombospondin motifs) are a group of proteases that are found both in mammals and invertebrates. Since the prototype ADAMTS-1 was first described in 1997, there has been a rapidly expanding body of literature describing this gene family and the proteins they encode.
Porter, Sarah, Clark, Ian M., Kevorkian, Lara, Edwards, Dylan R.   +3 more
openaire   +3 more sources

Hyalectanase Activities by the ADAMTS Metalloproteases [PDF]

International Journal of Molecular Sciences, 2021
The hyalectan family is composed of the proteoglycans aggrecan, versican, brevican and neurocan. Hyalectans, also known as lecticans, are components of the extracellular matrix of different tissues and play essential roles in key biological processes including skeletal development, and they are related to the correct maintenance of the vascular and ...
Fontanil López, Tania, Mohamedi Munarriz, Yamina, Espina Casado, Jorge, Obaya González, Álvaro Jesús, Cobo Díaz, Teresa, Cal Miguel, Santiago Jesús   +5 more
openaire   +3 more sources

Matrilin-2 Is Proteolytically Cleaved by ADAMTS-4 and ADAMTS-5 [PDF]

Molecules, 2014
Matrilin-2 is a widely distributed, oligomeric extracellular matrix protein that forms a filamentous network by binding to a variety of different extracellular matrix proteins. We found matrilin-2 proteolytic products in transfected cell lines in vitro and in mouse tissues in vivo.
Wang, Zhengke, Luo, Junming, Iwamoto, Satori, Chen, Qian   +3 more
openaire   +3 more sources

New Insights into ADAMTS Metalloproteases in the Central Nervous System

Biomolecules, 2020
Components of the extracellular matrix (ECM) are key players in regulating cellular functions throughout the whole organism. In fact, ECM components not only participate in tissue organization but also contribute to processes such as cellular maintenance,
Yamina Mohamedi, Tania Fontanil, Teresa Cobo, Santiago Cal, Alvaro J. Obaya   +4 more
doaj   +1 more source

ADAMTS proteoglycanases downregulation with impaired oocyte quality in PCOS

Archives of Endocrinology and Metabolism, 2021
Objective: A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) and ADAMTS-5 normal expression levels are essential for ovulation and subsequent fertilization.
Sepide Gohari taban, Iraj Amiri, Massoud Saidijam, Sara Soleimani asl, Mahnaz Yavangi, Elham Khanlarzadeh, Nooshin Mohammadpour, Tayebe Artimani   +7 more
doaj   +1 more source

Thrombotic thrombocytopenic purpura with decreased level of ADAMTS-13 activity and increased level of ADAMTS-13 inhibitor in an adolescent [PDF]

Korean Journal of Pediatrics, 2010
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy characterized by endothelial cell damage, resulting in microangiopathic hemolytic anemia, thrombocytopenia, and various degrees of neurological and renal impairment caused by ...
Eun Mi Yang, Dong Kyun Han, Hee Jo Baek, Young Ok Kim, Myung Geun Shin, Hoon Kook, Tai Ju Hwang   +6 more
doaj   +1 more source

First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator

Diagnostics, 2022
Background: We have previously shown that metzincin protease ADAMTS-4 accompanies renal fibrogenesis, as it appears in the blood of hemodialysis patients.
Ivana Kovacevic Vojtusek, Mario Laganovic, Marija Burek Kamenaric, Stela Bulimbasic, Stela Hrkac, Grgur Salai, Vanja Ivkovic, Marijana Coric, Rudjer Novak, Lovorka Grgurevic   +9 more
doaj   +1 more source

ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis

Frontiers in Cardiovascular Medicine, 2020
Background: Acute aortic dissection (AAD) is associated with degeneration of the aortic media and accompanied by vascular extracellular matrix (ECM) remodeling.
Tao Zeng, Jianting Gan, Yu Liu, Lei Shi, Zhengde Lu, Yan Xue, Rixin Xiong, Ling Liu, Zicong Yang, Yingzhong Lin, Jun Yuan   +10 more
doaj   +1 more source