Results 21 to 30 of about 12,128 (176)
Frontiers in Cardiovascular Medicine, 2020 Background: Acute aortic dissection (AAD) is associated with degeneration of the aortic media and accompanied by vascular extracellular matrix (ECM) remodeling.
Tao Zeng +10 more
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The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis [PDF]
Nature Clinical Practice Rheumatology, 2009 Loss of articular cartilage caused by extracellular matrix breakdown is the hallmark of arthritis. Degradative fragments of cartilage oligomeric matrix protein (COMP) have been observed in arthritic patients. ADAMTS-7 and ADAMTS-12, two members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, have been associated ...
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Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin
Cells, 2019 The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells.
Selene Pérez-García +9 more
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Characterization of ADAMTS-9 and ADAMTS-20 as a Distinct ADAMTS Subfamily Related to Caenorhabditis elegans GON-1 [PDF]
Journal of Biological Chemistry, 2003 We demonstrate that in humans, two metalloproteases, ADAMTS-9 (1935 amino acids) and ADAMTS-20 (1911 amino acids) are orthologs of GON-1, an ADAMTS protease required for gonadal morphogenesis in Caenorhabditis elegans. ADAMTS-9 and ADAMTS-20 have an identical modular structure, are distinct in possessing 15 TSRs and a unique C-terminal domain, and have
Robert P T, Somerville +8 more
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ADAMTS-12: Functions and Challenges for a Complex Metalloprotease
Frontiers in Molecular Biosciences, 2021 Nineteen members of the ADAMTS family of secreted zinc metalloproteinases are present in the human degradome. A wide range of different functions are being attributed to these enzymes and the number of their known substrates is considerably increasing in
Yamina Mohamedi +8 more
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Matrix Biology, 2015 The reproductive organs are unique among adult organs in that they must undergo continual tissue remodelling as a key aspect of their normal function. The processes for persistent maturation and release of new gametes, as well as fertilisation, implantation, placentation, gestation and parturition involve cyclic development and regression of tissues ...
Russell, Darryl L. +2 more
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BMC Gastroenterology, 2023 Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease that develops due to the impaired immune response in genetically susceptible individuals, and its etiopathogenesis is not fully elucidated.
Tahir Buran +6 more
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Philogenetic Analysis of ADAMTS-4 and ADAMTS-5 Structures
Natural Systems and Resources, 2020 ADAMTS-4 and -5 are aggrecanases that are involved in the development of osteoarthrosis by breaking aggrecan at various binding sites, of which cleavage in the Glu373-Ala374 bond plays the most important role in pathogenesis. Therefore, studying them is an urgent task to this day. Now, the structural features of these enzymes have already been studied,
Anastasia Korchagina, Pavel Krylov
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Diagnostics, 2021 Background: Endothelial dysfunction, coupled with inflammation, induces thrombo-inflammation. In COVID-19, this process is believed to be associated with clinical severity.
Giovanni Tiscia +11 more
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Expression of ADAMTS-1, ADAMTS-4, ADAMTS-5 and TIMP3 by hepatocellular carcinoma cell lines
International Journal of Oncology, 2012 Little is known about the expression or role of ADAMTS-1, -4 and -5 and their endogenous inhibitor TIMP3 in the liver in physiological and pathological conditions. Their expression was, therefore, investigated in the hepatocellular carcinoma cell lines HepG2 and HuH-7 using qRT-PCR and western blotting, and their cellular localisation by ...
Sharon L, Turner +4 more
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