Results 11 to 20 of about 12,128 (176)
ADAMTS expression in colorectal cancer. [PDF]
PLoS ONE, 2015 ADAMTSs are a family of secreted proteinases that share the metalloproteinase domain with matrix metalloproteinases (MMPs). By acting on a large panel of extracellular substrates, they control several cell functions such as fusion, adhesion ...
Serafula Filou +8 more
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The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases
Open Access Rheumatology: Research and Reviews, 2009 Edward A Lin1, Chuan-ju Liu1,21Department of Orthopaedic Surgery, 2Department of Cell Biology, New York University School of Medicine, New York, NY, USAAbstract: The a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) comprise a ...
Edward A Lin, Chuan-ju Liu
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The ADAMTS metalloproteinases [PDF]
Biochemical Journal, 2005 The ADAMTSs (adisintegrin and metalloproteinase with thrombospondin motifs) are a group of proteases that are found both in mammals and invertebrates. Since the prototype ADAMTS-1 was first described in 1997, there has been a rapidly expanding body of literature describing this gene family and the proteins they encode.
Porter, Sarah +3 more
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Cloning and Characterization of ADAMTS-14, a Novel ADAMTS Displaying High Homology with ADAMTS-2 and ADAMTS-3 [PDF]
Journal of Biological Chemistry, 2002 The processing of amino- and carboxyl-propeptides of fibrillar collagens is required to generate collagen monomers that correctly assemble into fibrils. Mutations in the ADAMTS2 gene, the aminopropeptidase of procollagen I and II, result in the accumulation of non-fully processed type I procollagen, causing human Ehlers-Danlos syndrome type VIIC and ...
Colige, Alain +8 more
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Hyalectanase Activities by the ADAMTS Metalloproteases [PDF]
International Journal of Molecular Sciences, 2021 The hyalectan family is composed of the proteoglycans aggrecan, versican, brevican and neurocan. Hyalectans, also known as lecticans, are components of the extracellular matrix of different tissues and play essential roles in key biological processes including skeletal development, and they are related to the correct maintenance of the vascular and ...
Fontanil López, Tania +5 more
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Matrilin-2 Is Proteolytically Cleaved by ADAMTS-4 and ADAMTS-5 [PDF]
Molecules, 2014 Matrilin-2 is a widely distributed, oligomeric extracellular matrix protein that forms a filamentous network by binding to a variety of different extracellular matrix proteins. We found matrilin-2 proteolytic products in transfected cell lines in vitro and in mouse tissues in vivo.
Wang, Zhengke +3 more
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New Insights into ADAMTS Metalloproteases in the Central Nervous System
Biomolecules, 2020 Components of the extracellular matrix (ECM) are key players in regulating cellular functions throughout the whole organism. In fact, ECM components not only participate in tissue organization but also contribute to processes such as cellular maintenance,
Yamina Mohamedi +4 more
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ADAMTS proteoglycanases downregulation with impaired oocyte quality in PCOS
Archives of Endocrinology and Metabolism, 2021 Objective: A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) and ADAMTS-5 normal expression levels are essential for ovulation and subsequent fertilization.
Sepide Gohari taban +7 more
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Thrombotic thrombocytopenic purpura with decreased level of ADAMTS-13 activity and increased level of ADAMTS-13 inhibitor in an adolescent [PDF]
Korean Journal of Pediatrics, 2010 Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy characterized by endothelial cell damage, resulting in microangiopathic hemolytic anemia, thrombocytopenia, and various degrees of neurological and renal impairment caused by ...
Eun Mi Yang +6 more
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Diagnostics, 2022 Background: We have previously shown that metzincin protease ADAMTS-4 accompanies renal fibrogenesis, as it appears in the blood of hemodialysis patients.
Ivana Kovacevic Vojtusek +9 more
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