Results 31 to 40 of about 12,128 (176)

ADAMTS-5: The story so far [PDF]

European Cells & Materials, 2008
The recent discovery of ADAMTS-5 as the major aggrecanase in mouse cartilage came as a surprise. A great deal of research had focused on ADAMTS-4 and much less was known about the regulation, expression and activity of ADAMTS-5. Two years on, it is still
A J Fosang, F M Rogerson, C J East, H Stanton   +3 more
doaj  

ADAMTS proteases and cancer

Matrix Biology, 2015
ADAMTSs (A disintegrin and metalloprotease domains with thrombospondins motifs) are complex extracellular proteases that have been related to both oncogenic and tumor-protective functions. These enzymes can be secreted by cancer and stromal cells and may contribute to modify the tumor microenvironment by multiple mechanisms. Thus, ADAMTSs can cleave or
Cal Miguel, Santiago Jesús, López Otín, Carlos   +1 more
openaire   +3 more sources

Multi-Omics Pan-Cancer Analysis of Procollagen N-Propeptidase Gene Family of ADAMTS as Novel Biomarkers to Associate with Prognosis, Tumor Immune Microenvironment, Signaling Pathways, and Drug Sensitivities

Frontiers in Bioscience-Landmark
Background: The extracellular matrix (ECM) modeling induced by the metalloproteinases is a vital characteristic for tumor progression. Previous studies mainly focus on the functions of two subgroups of metalloproteinases: matrix metalloproteinases (MMPs)
Yuxing Chen, Chaoyu Xiao, Qingxin Fan, Ye Zhang, Qiu Huang, Yunsheng Ou   +5 more
doaj   +1 more source

ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia

Hypertension in Pregnancy, 2018
The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies.
Müberra Namlı Kalem, Ziya Kalem, Tuncay Yüce, Feride Soylemez   +3 more
doaj   +1 more source

Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family.

PLoS Computational Biology, 2023
Numerous computational methods based on sequences or structures have been developed for the characterization of protein function, but they are still unsatisfactory to deal with the multiple functions of multi-domain protein families.
Olivier Dennler, François Coste, Samuel Blanquart, Catherine Belleannée, Nathalie Théret   +4 more
doaj   +1 more source

Gene Expression and Immunochemistry Analysis of ADAMTS-1 and Versican in Ameloblastoma

International Journal of Dentistry, 2022
Background. Ameloblastoma is a benign but locally invasive odontogenic epithelial tumor, associated with a high recurrence rate after treatment. The action of enzymes of the metalloproteinase family is important to the degraded extracellular matrix ...
Osvaldo Rodrigues de Souza Neto, Hellen Thais Fuzii, Suély Vieira Da Silva, Vanessa Morais Freitas, João de Jesus Viana Pinheiro   +4 more
doaj   +1 more source

ADAMTS-13 gene expression in antiphospholipid syndrome

Turkish Journal of Hematology, 2011
OBJECTIVE: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent thrombosis and fetal mortality. Thrombotic microangiopathy (TMA) is an important histological finding in catastrophic APS (CAPS) and in APS patients with ...
Veysel Sabri Hançer, Reyhan Diz Küçükkaya, Ayşegül Topal Sarıkaya   +2 more
doaj   +3 more sources

ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis

Scientific Reports, 2017
Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease ...
Eva Bengtsson, Karin Hultman, Pontus Dunér, Giuseppe Asciutto, Peter Almgren, Marju Orho-Melander, Olle Melander, Jan Nilsson, Anna Hultgårdh-Nilsson, Isabel Gonçalves   +9 more
doaj   +1 more source

Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles

Biomolecules, 2020
Aberrant extracellular matrix synthesis and remodeling contributes to muscle degeneration and weakness in Duchenne muscular dystrophy (DMD). ADAMTS-5, a secreted metalloproteinase with catalytic activity against versican, is implicated in myogenesis and ...
Alex B. Addinsall, Leonard G. Forgan, Natasha L. McRae, Rhys W. Kelly, Penny L. McDonald, Bryony McNeill, Daniel R. McCulloch, Nicole Stupka   +7 more
doaj   +1 more source

The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. [PDF]

PLoS ONE, 2015
The specific degradation of type II collagen and aggrecan by matrix metalloproteinase (MMP)-9, -13 and ADAMTS-4 and -5 (aggrecanase-1 and -2) in the cartilage matrix is a critical step in pathology of osteoarthritis (OA).
Yi He, Qinlong Zheng, MengMeng Jiang, Shu Sun, Thorbjørn G Christiansen, Moustapha Kassem, Morten A Karsdal, Anne C Bay-Jensen   +7 more
doaj   +1 more source