Results 31 to 40 of about 15,848 (207)

The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis [PDF]

Nature Clinical Practice Rheumatology, 2009
Loss of articular cartilage caused by extracellular matrix breakdown is the hallmark of arthritis. Degradative fragments of cartilage oligomeric matrix protein (COMP) have been observed in arthritic patients. ADAMTS-7 and ADAMTS-12, two members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, have been associated ...
openaire   +2 more sources

Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin

Cells, 2019
The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells.
Selene Pérez-García, Mar Carrión, Irene Gutiérrez-Cañas, Raúl Villanueva-Romero, David Castro, Carmen Martínez, Isidoro González-Álvaro, Francisco J. Blanco, Yasmina Juarranz, Rosa P. Gomariz   +9 more
doaj   +1 more source

Characterization of ADAMTS-9 and ADAMTS-20 as a Distinct ADAMTS Subfamily Related to Caenorhabditis elegans GON-1 [PDF]

Journal of Biological Chemistry, 2003
We demonstrate that in humans, two metalloproteases, ADAMTS-9 (1935 amino acids) and ADAMTS-20 (1911 amino acids) are orthologs of GON-1, an ADAMTS protease required for gonadal morphogenesis in Caenorhabditis elegans. ADAMTS-9 and ADAMTS-20 have an identical modular structure, are distinct in possessing 15 TSRs and a unique C-terminal domain, and have
Robert P T, Somerville, Jean-Michel, Longpre, Katherine A, Jungers, J Michael, Engle, Monique, Ross, Stephen, Evanko, Thomas N, Wight, Richard, Leduc, Suneel S, Apte   +8 more
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ADAMTS -1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes [PDF]

, 2006
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) enzymes are a recently described group of metalloproteinases. The substrates degraded by ADAMTS-1, -4 and -5 suggests that they play a role in turnover of extracellular matrix in the
Woodroofe, N., Surr, J., Allan, S., Stock, C. J., Cross, A. K., Haddock, G., Buttle, D. J., Bunning, R. A.   +7 more
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ADAMTS proteases in fertility

Matrix Biology, 2015
The reproductive organs are unique among adult organs in that they must undergo continual tissue remodelling as a key aspect of their normal function. The processes for persistent maturation and release of new gametes, as well as fertilisation, implantation, placentation, gestation and parturition involve cyclic development and regression of tissues ...
Russell, Darryl L., Brown, Hannah M., Dunning, Kylie R.   +2 more
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Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis [PDF]

, 2005
Experimental autoimmune encephalomyelitis (EAE) is an animal model of inflammatory demyelination, a pathological event common to multiple sclerosis (MS). During CNS inflammation there are alterations in the extracellular matrix (ECM).
Woodroofe, N., Bunning, R. A D, Woodroofe, M. N., Plumb, J., Surr, J., Cross, A. K., Haddock, G., Buttle, D. J.   +7 more
core   +1 more source

ADAMTS-12: Functions and Challenges for a Complex Metalloprotease

Frontiers in Molecular Biosciences, 2021
Nineteen members of the ADAMTS family of secreted zinc metalloproteinases are present in the human degradome. A wide range of different functions are being attributed to these enzymes and the number of their known substrates is considerably increasing in
Yamina Mohamedi, Tania Fontanil, Tania Fontanil, Santiago Cal, Santiago Cal, Teresa Cobo, Teresa Cobo, Álvaro J. Obaya, Álvaro J. Obaya   +8 more
doaj   +1 more source

Philogenetic Analysis of ADAMTS-4 and ADAMTS-5 Structures

Natural Systems and Resources, 2020
ADAMTS-4 and -5 are aggrecanases that are involved in the development of osteoarthrosis by breaking aggrecan at various binding sites, of which cleavage in the Glu373-Ala374 bond plays the most important role in pathogenesis. Therefore, studying them is an urgent task to this day. Now, the structural features of these enzymes have already been studied,
Anastasia Korchagina, Pavel Krylov
openaire   +1 more source

Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M., Chapple, JP, Chapple, J.P., Knight, MM, Thompson, CL, Thompson, C.L.   +5 more
core   +1 more source

Development of a fluorogenic ADAMTS-7 substrate [PDF]

, 2021
The extracellular protease ADAMTS-7 has been identified as a potential therapeutic target in atherosclerosis and associated diseases such as coronary artery disease (CAD). However, ADAMTS-7 inhibitors have not been reported so far.
de Groot R., De Vita E., Tuccinardi T., Nuti E., Howell S., Snijders A. P., Rossello A., Mehmood S., Buemi F., Santamaria S., Cuffaro D.   +10 more
core   +4 more sources