Results 31 to 40 of about 69,866 (210)

Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State

Membranes, 2022
A disintegrin and metalloproteinase 15 (ADAM15) is a member of the ADAM family of sheddases. Its genetic ablation in mice suggests that ADAM15 plays an important role in a wide variety of biological functions, including cartilage homeostasis ...
Chun-Yao Yang, Simone Bonelli, Matteo Calligaris, Anna Paola Carreca, Stephan A. Müller, Stefan F. Lichtenthaler, Linda Troeberg, Simone D. Scilabra   +7 more
doaj   +1 more source

Conservation and divergence of ADAM family proteins in the Xenopus genome

BMC Evolutionary Biology, 2010
Background Members of the disintegrin metalloproteinase (ADAM) family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins.
Shah Anoop, Bridges Lance C, Xu Guofeng, Whittaker Charles A, Wei Shuo, White Judith M, DeSimone Douglas W   +6 more
doaj   +1 more source

Correlation Between A Disintegrin and Metalloproteinase (ADAM) Family Proteins (8, 10, 17, 22) and Link with Neuroplasticity in Autism Spectrum Disorder

Current Issues in Molecular Biology
Background: Autism spectrum disorder (ASD) is a condition related to neurodevelopment, typically identified by impaired social interactions and repetitive stereotypical behaviors.
Dost Muhammad Halepoto, Laila Al-Ayadhi, Abdulrahman Alhowikan, Nadra Elamin, Durria Abdulmaged, Aurangzeb Halepota, Sarah Al-Mazidi   +6 more
doaj   +1 more source

Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus

Frontiers in Cellular Neuroscience, 2015
Brain is continuously altered in response to experience and environmental changes. One of the underlying mechanisms is synaptic plasticity, which is manifested by modification of synapse structure and function.
Grzegorz eWiera, Grzegorz eWiera, Jerzy W Mozrzymas, Jerzy W Mozrzymas   +3 more
doaj   +1 more source

Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes

Cardiovascular Diabetology, 2007
Aims Type 2 diabetes is characterised by increased plasma concentrations of pro-inflammatory cytokines [such as tumour necrosis factor – alpha; TNF-α] and soluble forms of adhesion molecules involved in leukocyte – endothelial interactions.
Dozio Nicoletta, Hughes David A, Worley Joanna R, Gavrilovic Jelena, Sampson Mike J   +4 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Differential Spatio-Temporal Regulation of MMPs in the 5xFAD Mouse Model of Alzheimer’s disease: Evidence for aPro-Amyloidogenic Role of MT1-MMP

Frontiers in Aging Neuroscience, 2014
Matrix metalloproteinases (MMPs) are pleiotropic endopeptidases involved in a variety of neurodegenerative/neuroinflammatory processes through their interactions with a large number of substrates.
Nathalie ePy, Amandine eBonnet, Anne eBernard, Yannick eMarchalant, Eliane eCharrat, Frédéric eChecler, Michel eKhrestchatisky, Kévin eBaranger, Santiago eRivera   +8 more
doaj   +1 more source

Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction

Frontiers in Molecular Biosciences, 2021
Disintegrins are small cysteine-rich proteins found in a variety of snake venom. These proteins selectively modulate integrin function, heterodimeric receptors involved in cell-cell and cell-matrix interaction that are widely studied as therapeutic ...
Ariana A. Vasconcelos, Ariana A. Vasconcelos, Jorge C. Estrada, Victor David, Luciana S. Wermelinger, Fabio C. L. Almeida, Fabio C. L. Almeida, Russolina B. Zingali   +7 more
doaj   +1 more source