Results 41 to 50 of about 69,149 (111)

A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions

Toxins, 2016
Since the discovery of the first disintegrin protein from snake venom and the following identification of a mammalian membrane-anchored metalloprotease-disintegrin implicated in fertilization, almost three decades of studies have identified additional ...
Nives Giebeler, Paola Zigrino
doaj   +1 more source

Extracellular Vesicle Proteome of Breast Cancer Patients with and Without Cognitive Impairment Following Anthracycline-based Chemotherapy: An Exploratory Study

Biomarker Insights, 2021
Cognitive impairment due to cancer and its therapy is a major concern among cancer patients and survivors. Extracellular vesicle (EVs) composition altered by cancer and chemotherapy may affect neurological processes such as neuroplasticity, potentially ...
Yong Qin Koh, Ding Quan Ng, Chiu Chin Ng, Adrian Boey, Meng Wei, Siu Kwan Sze, Han Kiat Ho, Munjal Acharya, Charles L Limoli, Alexandre Chan   +9 more
doaj   +1 more source

Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons

Scientific Reports, 2017
IgLONs are members of the immunoglobulin superfamily of cell adhesion proteins implicated in the process of neuronal outgrowth, cell adhesion and subdomain target recognition.
Ricardo L. Sanz, Gino B. Ferraro, Marie-Pier Girouard, Alyson E. Fournier   +3 more
doaj   +1 more source

Relapse of congenital thrombotic thrombocytopenic purpura, after spontaneous remission, in a second-trimester primigravida: case report and review of the literature

São Paulo Medical Journal, 2017
CONTEXT: Thrombotic microangiopathy syndrome or thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) describes distinct diseases sharing common pathological features: microangiopathic hemolytic anemia and thrombocytopenia, without any
Donavan de Souza Lúcio, Jacqueline Foelkel Pignatari, Marcelo Gil Cliquet, Henri Augusto Korkes   +3 more
doaj   +1 more source

The Prediction of Intrinsically Disordered Proteins Based on Feature Selection

Algorithms, 2019
Intrinsically disordered proteins perform a variety of important biological functions, which makes their accurate prediction useful for a wide range of applications.
Hao He, Jiaxiang Zhao, Guiling Sun
doaj   +1 more source

Novosadski golozrni, a spring oat variety [PDF]

Selekcija i Semenarstvo, 2001
The naked oat variety Novosadski golozrni was developed from a cross between the variety Adam and a spring-type naked oat line from Canada. The variety is early, medium tall, with excellent resistance to lodging. The yield of Novosadski golozrni is 30-40%
Pržulj Novo, Mihailović Vojislav, Momčilović Vojislava   +2 more
doaj  

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

Molecular Neurodegeneration, 2009
Background The low-density lipoprotein receptor-related protein 1 (LRP1) plays critical roles in lipid metabolism, cell survival, and the clearance of amyloid-β (Aβ) peptide. Functional soluble LRP1 (sLRP1) has been detected in circulating human placenta;
Reiss Karina, Verbeek Marcel M, Tran Hien, Zhang Juan, Liu Qiang, Estus Steven, Bu Guojun   +6 more
doaj   +1 more source

Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding

Nature Communications
Overexpression of the transmembrane matrix metalloproteinase MT1-MMP/MMP14 promotes cancer cell invasion. Here we show that MT1-MMP-positive cancer cells turn MT1-MMP-negative cells invasive by transferring a soluble catalytic ectodomain of MT1-MMP ...
Eva Maria Wenzel, Nina Marie Pedersen, Liv Anker Elfmark, Ling Wang, Ingrid Kjos, Espen Stang, Lene Malerød, Andreas Brech, Harald Stenmark, Camilla Raiborg   +9 more
doaj   +1 more source

Inactive metallopeptidase homologs: the secret lives of pseudopeptidases

Frontiers in Molecular Biosciences
Inactive enzyme homologs, or pseudoenzymes, are proteins, found within most enzyme families, that are incapable of performing catalysis. Rather than catalysis, they are involved in protein-protein interactions, sometimes regulating the activity of their ...
Peter J. Lyons
doaj   +1 more source

The role of some ADAM-proteins and activation of the insulin growth factor-related pathway in colorectal cancer. [PDF]

Cent Eur J Immunol, 2018
Walkiewicz K, Nowakowska-Zajdel E, Kozieł P, Muc-Wierzgoń M.   +3 more
europepmc   +1 more source