Results 81 to 90 of about 2,414,840 (297)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement [PDF]

, 2007
The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues.
Matthew L Rotondi, Trevor P Creamer, Henry A. Choy, Brissette Catherine A., Kraiczy Peter, DeMoll, Edward, Edward Demoll, Peter Kraiczy, Stevenson, Brian, Suchard, Marc A, Creamer, Trevor P., Cooley Anne E., Matthew L. Rotondi, Kraiczy, Peter, Suchard, Marc A., Marc A. Suchard, Haake David A., Marija Pinne, Brissette, Catherine A, Catherine A. Brissette, Cooley, Anne E., Marc A Suchard, DeMoll Edward, Creamer, Trevor P, Pinne Marija, Verma, Ashutosh, Miller M. Clarke, Choy Henry A., Miller, M. Clarke, M Clarke Miller, Choy, Henry A, Pinne, Marija, Catherine A Brissette, Trevor P. Creamer, Verma Ashutosh, Haake, David A, Anne E. Cooley, Brissette, Catherine A., Rotondi, Matthew L., Suchard Marc A., Stevenson Brian, Creamer Trevor P., Brian Stevenson, Ashutosh Verma, M. Clarke Miller, Miller, M Clarke, Rotondi, Matthew L, Haake, David A., Rotondi Matthew L., Henry A Choy, David A Haake, Cooley, Anne E, Choy, Henry A., Anne E Cooley, David A. Haake   +54 more
core   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

The Prediction of Intrinsically Disordered Proteins Based on Feature Selection

Algorithms, 2019
Intrinsically disordered proteins perform a variety of important biological functions, which makes their accurate prediction useful for a wide range of applications.
Hao He, Jiaxiang Zhao, Guiling Sun
doaj   +1 more source

[The importance of ADAM family proteins in malignant tumors].

Postepy higieny i medycyny doswiadczalnej (Online), 2016
Increasing numbers of reports about the role of adamalysins (ADAM) in malignant tumors are being published. To date, more than 30 representatives of this group, out of which about 20 occur in humans, have been described. The ADAM family is a homogeneous group of proteins which regulate, from the stage of embryogenesis, a series of processes such as ...
Katarzyna, Walkiewicz, Monika, Gętek, Małgorzata, Muc-Wierzgoń, Teresa, Kokot, Ewa, Nowakowska-Zajdel   +4 more
openaire   +1 more source

DyProL: Dynamic Ensemble Representation Learning for Protein–Nucleic Acid Binding Site Prediction

Advanced Science, EarlyView.
Protein function is represented as a dynamic conformational ensemble rather than a single static structure. A multi‐conformation geometric attention framework aligns, clusters, and learns representative states to capture residue‐ and ensemble‐level signals. Integrating structural dynamics improves interpretable protein‐NA binding prediction and reveals
Pengpai Li, Yiman Liu, Liya Liang, Rongming Liu   +3 more
wiley   +1 more source

Cartoon sketch, ca. 1880s [picture] /

, 1870
Title devised by cataloguer based on information from acquisitions documentation.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4975070; Donated by Mrs Florence Walker, nee Forster, grand-daughter of the artist,
Forster, Adam, 1848-1928.
core  

AI‐Powered, Temperature‐Resolved Centrifugal Microfluidics for Rapid 3D Phase‐Diagram Generation of Biomolecular Condensates

Advanced Science, EarlyView.
By merging centrifugal microfluidics, precise temperature control, and AI image recognition, T‐PhaseMap transforms biomolecular condensate phase mapping into a rapid, temperature‐resolved workflow. It generates 3D composition–temperature phase diagrams within 30 min, resolves four phase states, and uncovers temperature‐dependent heparin sodium ...
Jiashuo Li, Pengjie Li, Kaiting Zhang, Yongqi Guo, Peng Chen, Bi‐Feng Liu, Yiwei Li   +6 more
wiley   +1 more source

Nonnative Thiol and Aniline Methylation, Including Enantioselective Dithiol Desymmetrization, by Multicomponent Cobamide‐Dependent Methyltransferases Using Unactivated Methyl Donors

Angewandte Chemie, EarlyView.
Mixed MtaABC/MtgABC methyltransferase systems were developed for non‐native thiol and aniline methylation using the unactivated methyl donors methanol and glycine betaine. The platform enabled site‐selective and enantioselective methylation with turnover number up to 6000, representing the first enantioselective non‐native catalysis by cobamide ...
Amardeep Kumar, Osman Ishag Adam, Paras Gupta, Jared C. Lewis   +3 more
wiley   +2 more sources

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source