Results 221 to 230 of about 171,066 (327)

ADAM interact with large protein complexes to regulate Histone modification, gene expression and splicing. [PDF]

Ankit Pandey, Hélène Cousin, Shiv Kumar, Louis H. Taylor, Ashmita Chander, Kelsey Coppenrath, Nikko‐Ideen Shaidani, Marko E. Horb, Dominique Alfandari   +8 more
openalex   +1 more source

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

Plasma Glial Fibrillary Acidic Protein and Neurofilament Light Are Elevated in Bipolar Depression: Evidence for Neuroprogression and Astrogliosis

Bipolar Disorders, EarlyView.
ABSTRACT Background Recent advances now allow detection of brain‐specific proteins in blood, including neurofilament light chain (NfL), a marker of axonal pathology, and glial fibrillary acidic protein (GFAP), indicative of astrocytic activation. Given the evidence of astroglial pathology and neuronal dysfunction in bipolar disorder, and ongoing ...
Matthew J. Y. Kang, Dhamidhu Eratne, Olivia Dean, Michael Berk, Adam J. Walker, Cassandra Wannan, Charles B. Malpas, Claudia Cicognola, Shorena Janelidze, Oskar Hansson, Jasleen Grewal, Philip B. Mitchell, Malcolm Hopwood, Christos Pantelis, Alexander F. Santillo, Dennis Velakoulis   +15 more
wiley   +1 more source

Heuristic optimization in classification atoms in molecules using GCN via uniform simulated annealing. [PDF]

Sci Rep
Polowczyk A, Polowczyk A, Woźniak M.
europepmc   +1 more source

Mapping VEXAS‐associated and rare UBA1 variants in the United Kingdom: Insights from patient cohorts and the general population

British Journal of Haematology, EarlyView.
VEXAS syndrome is a late‐onset inflammatory disorder with rheumatological and haematological features. Epidemiological studies of VEXAS syndrome so far have been limited. Analysis of various UK cohorts estimates the incidence of VEXAS to be 1.51/100 000, or 171 new cases in the population of men over the age of 50 who are being investigated for myeloid
Ana Martinez Rodriguez, Leon Chang, Dorota Rowczenio, Alexandra Smith, Ebun Omoyinmi, James A. Poulter, Andrew McGregor, Sebastian Francis, Roochi Trikha, Adam Al‐Hakim, Kar Lok Kong, David G. Kent, Helen Lachmann, Austin Kulasekararaj, Catherine Cargo, Sinisa Savic   +15 more
wiley   +1 more source

Effect of a Laparoscopic Donor Nephrectomy in Healthy Living Kidney Donors on the Acute Phase Response Using Either Propofol or Sevoflurane Anesthesia. [PDF]

Int J Mol Sci
Brattinga B, Huang H, Maslau S, Thorne AM, Hunter J, Knight S, Struys MMRF, Leuvenink HGD, de Bock GH, Ploeg RJ, Kessler BM, Nieuwenhuijs-Moeke GJ.   +11 more
europepmc   +1 more source

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease

Brain Pathology, EarlyView.
HSV‐1 infection alters MAPT splicing and promotes Tau pathology in neural models of Alzheimer's disease. HSV‐1 infection in brain organoids and neuronal models increase 4R‐MAPT splicing and Tau hyperphosphorylation. HSV‐1 ICP27 is both necessary and sufficient for inducing these changes highlighting the potential role of HSV‐1 in Alzheimer's disease ...
Emmanuel C. Ijezie, Michael J. Miller, Celine Hardy, Ava R. Jarvis, Timothy F. Czajka, Lianna D'Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy, David C. Butler   +9 more
wiley   +1 more source

Exchange transfusion and pre-filter apheresis dilution for hyperviscosity syndrome refractory to conventional therapeutic plasma exchange in a patient with IgA multiple myeloma. [PDF]

Transfusion
Valin-Thorburn A, Desforges SM, Corsilli D, Guimond JG, Adam JP, Maietta A, Routy B, Lemay AS.   +7 more
europepmc   +1 more source

Network medicine and systems pharmacology approaches to predicting adverse drug effects

British Journal of Pharmacology, EarlyView.
Identifying and understanding the relationships between drug intake and adverse effects that can occur due to inadvertent molecular interactions between drugs and targets is a difficult task, especially considering the numerous variables that can influence the onset of such events.
Alessio Funari, Giulia Fiscon, Paola Paci   +2 more
wiley   +1 more source

DNM1L-mediated fission governs mitophagy & mitochondrial biogenesis during myogenic differentiation. [PDF]

Cell Commun Signal
Rahman FA, Friedrich Yap JM, Joseph TM, Adam AM, Chapman SM, Quadrilatero J.   +5 more
europepmc   +1 more source