Results 31 to 40 of about 10,772,271 (320)
Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein [PDF]
Journal of Biological Chemistry, 2009 The cellular prion protein (PrP(C)) is essential for the pathogenesis and transmission of prion diseases. PrP(C) is bound to the plasma membrane via a glycosylphosphatidylinositol anchor, although a secreted, soluble form has also been identified.
Taylor, David R +6 more
openaire +4 more sources
Evolutionary divergence and functions of the
Human Genomics, 2009 The 'A-disintegrin and metalloproteinase' (ADAM) and 'A-disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) genes make up two similar, yet distinct, gene families.
Brocker Chad N +2 more
doaj +1 more source
Snake venom disintegrins update: insights about new findings [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2023 Snake venom disintegrins are low molecular weight, non-enzymatic proteins rich in cysteine, present in the venom of snakes from the families Viperidae, Crotalidae, Atractaspididae, Elapidae, and Colubridae.
Gabriela de Oliveira Almeida +3 more
doaj +1 more source
Proteomic analysis of Biomphalaria glabrata plasma proteins with binding affinity to those expressed by early developing larval Schistosoma mansoni. [PDF]
PLoS Pathogens, 2017 Interactions between early developing Schistosoma mansoni larval stages and the hemolymph of its snail intermediate host represent the first molecular encounter with the snail's immune system.
Xiao-Jun Wu +7 more
doaj +1 more source
Nature Neuroscience, 2021 Understanding the tissue-specific genetic controls of protein levels is essential to uncover mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic atlas of protein levels in three tissues relevant to neurological ...
Cheng-Ran Yang +21 more
semanticscholar +1 more source
ADAM-15 Disintegrin-Like Domain Structure and Function
Toxins, 2010 The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals.
Dong Lu +3 more
doaj +1 more source
Nature Biotechnology, 2022 Targeted degradation of cell surface and extracellular proteins via lysosomal delivery is an important means to modulate extracellular biology. However, these approaches have limitations due to lack of modularity, ease of development, restricted tissue ...
Katarina Pance +7 more
semanticscholar +1 more source
Role of hypoxia-related proteins in adenoid cystic carcinoma invasion
Diagnostic Pathology, 2020 Background Among cancers affecting the oral cavity, adenoid cystic carcinoma (ACC) is a relatively common malignant neoplasm. It has high rates of metastasis and recurrence and is associated with significant morbidity.
Raíssa Pinheiro de Mendonça +9 more
doaj +1 more source
ADAM and ADAMTS Proteases in Hepatic Disorders
Journal of Renal and Hepatic Disorders, 2019 Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the ...
Dirk Schmidt-Arras +2 more
doaj +1 more source
BMC Cancer, 2018 Background A-disintegrin and metalloproteinases (ADAMs) are members of a family of multidomain transmembrane and secreted proteins. Specific ADAMs are upregulated in human cancers and correlated with tumor progression and poor outcome, but rarely studied
Xiaodong Jiao +6 more
doaj +1 more source