Results 231 to 240 of about 10,772,271 (320)

Distinct Gene Expression Profiles of Ara h 2‐Specific B Cells in Desensitization and Tolerance During Peanut Oral Immunotherapy

open access: yesAllergy, EarlyView.
Gene expression of Ara h 2‐specific B cells over the course of the peanut OIT. Isotype of allergen‐specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen‐specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation.
Stephan R. Schneider   +48 more
wiley   +1 more source

Delivery and adherence of biomarker‐guided antibiotic treatment protocols in the ADAPT‐Sepsis clinical trial: an in‐trial descriptive process evaluation of daily procalcitonin‐ and C‐reactive protein‐guided protocols

open access: yesAnaesthesia, EarlyView.
Summary Introduction Biomarker‐guided antibiotic protocols using daily procalcitonin or C‐reactive protein have been proposed to optimise antibiotic duration in sepsis. This pre‐planned process evaluation of the ADAPT‐Sepsis trial examined delivery and clinician adherence to procalcitonin‐ and C‐reactive protein‐guided protocols.
Ranjit Lall   +536 more
wiley   +1 more source

seqme: a Python library for evaluating biological sequence design from generative models. [PDF]

open access: yesBioinform Adv
Møller-Larsen R   +6 more
europepmc   +1 more source

Deep‐Learning‐Based Profiling of Mouse Sperm Head and Neck Morphology Reveals Coordinated Structural Variation

open access: yesAndrology, EarlyView.
ABSTRACT Background Mammalian sperm head morphology varies across species and dictates fertilization capability. Rodent sperm have asymmetric, hook‐shaped heads, complicating analysis. Despite widespread biomedical use, current tools poorly characterize these complex variations.
Gwidong Han   +3 more
wiley   +1 more source

Rhomboid protease RHBDL2 is a calcium-activated suppressor of EGFR signalling in keratinocytes. [PDF]

open access: yesCell Mol Life Sci
Johnson N   +19 more
europepmc   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

ADAM19 Promotes EMT‐Related Changes and Serves as a Prognostic Marker in Circulating Tumor Cells of Renal Cell Carcinoma

open access: yesCancer Science, EarlyView.
ADAM19 is associated with EMT‐related malignant phenotypes and NOTCH/NF‐κB pathway activity in RCC and may serve as a prognostic biomarker in CTCs. ABSTRACT Detection of circulating tumor cells (CTCs), particularly characterization of their epithelial‐mesenchymal transition (EMT) phenotypes, may improve prognostic accuracy for malignancies ...
Minxin He   +8 more
wiley   +1 more source

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