Results 41 to 50 of about 182,768 (228)
BMC Cancer, 2018 Background A-disintegrin and metalloproteinases (ADAMs) are members of a family of multidomain transmembrane and secreted proteins. Specific ADAMs are upregulated in human cancers and correlated with tumor progression and poor outcome, but rarely studied
Xiaodong Jiao +6 more
doaj +1 more source
Membranes, 2022 A disintegrin and metalloproteinase 15 (ADAM15) is a member of the ADAM family of sheddases. Its genetic ablation in mice suggests that ADAM15 plays an important role in a wide variety of biological functions, including cartilage homeostasis ...
Chun-Yao Yang +7 more
doaj +1 more source
Expression of ADAM‐9 mRNA and protein in human breast cancer [PDF]
International Journal of Cancer, 2003 AbstractThe ADAMs (a disintegrin and metalloprotease) are membrane proteins containing both protease and adhesion domains and thus may be potentially important in cancer invasion and metastasis. The aim of our study was to investigate the distribution and potential clinical significance of ADAM‐9 in breast cancer.
O'Shea C +7 more
openaire +3 more sources
Characterization of Mammalian ADAM2 and Its Absence from Human Sperm. [PDF]
PLoS ONE, 2016 The members of the ADAM (a disintegrin and metalloprotease) family are membrane-anchored multi-domain proteins that play prominent roles in male reproduction.
Heejin Choi +10 more
doaj +1 more source
Metallopanstimulin as a marker for head and neck cancer [PDF]
, 2004 BACKGROUND: Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC).
A Agrawal +28 more
core +4 more sources
Identification of Giardia lamblia DHHC Proteins and the Role of Protein S-palmitoylation in the Encystation Process [PDF]
, 2014 Protein S-palmitoylation, a hydrophobic post-translational modification, is performed by protein acyltransferases that have a common DHHC Cys-rich domain (DHHC proteins), and provides a regulatory switch for protein membrane association. In this work, we
A Criscuolo +114 more
core +3 more sources
Advances in the design and development of oncolytic measles viruses. [PDF]
, 2015 A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian +2 more
core +1 more source
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source
Mammalian telomeres and their partnership with lamins [PDF]
, 2016 Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA +2 more
core +1 more source
The Suppressor of AAC2 Lethality SAL1 Modulates Sensitivity of Heterologously Expressed Artemia ADP/ATP Carrier to Bongkrekate in Yeast [PDF]
, 2013 The ADP/ATP carrier protein (AAC) expressed in Artemia franciscana is refractory to bongkrekate. We generated two strains of Saccharomyces cerevisiae where AAC1 and AAC3 were inactivated and the AAC2 isoform was replaced with Artemia AAC containing a ...
A Keller +71 more
core +4 more sources