Results 161 to 170 of about 69,298 (248)

Cucurbitacin B Promotes Tumor Necrosis Factor Receptor 1 Ectodomain Shedding by Selectively Activating the Extracellular Signal-Regulated Kinase Signaling Pathway. [PDF]

Int J Mol Sci
Yarangsee P, Fukai I, Phol S, Kinugawa K, Kusagawa E, Miyake Y, Kataoka T.   +6 more
europepmc   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, EarlyView.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Physical Implausibility of Carbohydrate Ligands in Results of Deep Learning-Based Cofolding Methods. [PDF]

J Chem Inf Model
Luthfi M, Simpkin AJ, Elliott LG, Sompornpisut P, Rigden DJ.   +4 more
europepmc   +1 more source

Changes in gastrointestinal motility and gut hormone secretion after Roux‐en‐Y gastric bypass and sleeve gastrectomy for individuals with severe obesity

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Background Bariatric surgery is very effective in long‐term weight management. The present study was undertaken to investigate the short‐term effects of sleeve gastrectomy (SG) and of Roux‐en‐Y gastric bypass (RYGB) on (a) gastrointestinal (GI) motility, that is gastric emptying and oro‐cecal transit time and (b) secretion of regulatory gut ...
Jennifer A. Wilbrink, Mark van Avesaat, Simon W. Nienhuijs, Arnold Stronkhorst, Ad A. M. Masclee   +4 more
wiley   +1 more source

Nutrition at the Frontier of Allergy-From Oral Challenges to the Microbiome. [PDF]

Nutrients
Sybilski AJ, Balas W.
europepmc   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Speech, language, social communication, and communication assessments in Rett syndrome: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
This systematic overview highlights communication impairment as a defining feature of Rett syndrome, with expressive language consistently affected more severely than receptive language and social ability. Across the literature, most studies rely on caregiver‐reported measures, with relatively few employing direct or objective measurements of speech ...
Lucas N. Raniolo, Ruth O. Braden, Jana von Hehn, John Christodoulou, David N. Lieberman, David J. Amor, Adam P. Vogel   +6 more
wiley   +1 more source

A multimodal human protein embeddings database: DeepDrug Protein Embeddings Bank (DPEB). [PDF]

NAR Genom Bioinform
Sajol MSI, Rajasekaran M, Gemeinhardt H, Bess A, Alvin C, Mukhopadhyay S.   +5 more
europepmc   +1 more source

Baseline Computed Tomography Coronary Angiography and Polygenic Risk Profiles in Adults With Type 2 Diabetes: A Cross‐Sectional Analysis From the VOLTAIRE Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To characterise baseline clinical, anatomical, and genetic cardiovascular risk profiles in participants enrolled in the VOLTAIRE (Evaluation of Polygenic Scores and CT Imaging in Risk Factor Modification in Patients with Type 2 Diabetes) study and examine concordance across these domains. Methods This analysis included adults with T2D who
Ruofei (Trophy) Chen, Adam J. Nelson, Sophia Zoungas, Robyn A. Clark, Sean Tan, Esther F. Davis, Melissa C. Southey, Andrew Lin, Giuseppe Di Giovanni, Masashi Fujino, Jennifer Wong, Robert L. O'Reilly, Jacqueline S. Dron, Stephen J. Nicholls   +13 more
wiley   +1 more source

Proteomic signatures of cervical mucus associated with fertility in Bali heifers (<i>Bos javanicus</i>): Implications for biomarker-based selection in artificial insemination programs. [PDF]

Vet World
Yusuf M, Toleng AL, Hasrin H, Baharun A, Diansyah AM, Santoso S, Rahmat R, Alfian AM, Masturi M, Sahiruddin S, Amrullah MF, Adam AAS, Jannah M.   +12 more
europepmc   +1 more source