Results 91 to 100 of about 10,772,271 (320)
Advanced Science, EarlyView.A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li +9 more
wiley +1 more source
Cell Death and Disease, 2018 Hepatocellular carcinoma (HCC) is one of the greatest life threats for Chinese people, and the prognosis of this malignancy is poor due to the strong chemotherapy resistance in patients.
Ying-Shi Zhang +11 more
semanticscholar +1 more source
[The importance of ADAM family proteins in malignant tumors].
Postepy higieny i medycyny doswiadczalnej (Online), 2016 Increasing numbers of reports about the role of adamalysins (ADAM) in malignant tumors are being published. To date, more than 30 representatives of this group, out of which about 20 occur in humans, have been described. The ADAM family is a homogeneous group of proteins which regulate, from the stage of embryogenesis, a series of processes such as ...
Katarzyna, Walkiewicz +4 more
openaire +1 more source
DyProL: Dynamic Ensemble Representation Learning for Protein–Nucleic Acid Binding Site Prediction
Advanced Science, EarlyView.Protein function is represented as a dynamic conformational ensemble rather than a single static structure. A multi‐conformation geometric attention framework aligns, clusters, and learns representative states to capture residue‐ and ensemble‐level signals. Integrating structural dynamics improves interpretable protein‐NA binding prediction and reveals
Pengpai Li +3 more
wiley +1 more source
Advanced Science, EarlyView.By merging centrifugal microfluidics, precise temperature control, and AI image recognition, T‐PhaseMap transforms biomolecular condensate phase mapping into a rapid, temperature‐resolved workflow. It generates 3D composition–temperature phase diagrams within 30 min, resolves four phase states, and uncovers temperature‐dependent heparin sodium ...
Jiashuo Li +6 more
wiley +1 more source
ADAM Report #14 (September 1997)
, 1997 ADAM REPORT # 14, September 1997 1. Wages and Innovative Clauses 2.
ACIRRT; Australian Centre for Industrial Relations Research and Training
core
Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution
Advanced Science, EarlyView.MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge +6 more
wiley +1 more source
BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.
Cell Reports, 2017 B cell activating factor (BAFF) provides B cells with essential survival signals. It binds to three receptors: BAFFR, TACI, and BCMA that are differentially expressed by B cell subsets.
C. Smulski +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann +7 more
wiley +1 more source