Results 41 to 50 of about 10,772,271 (320)

A Metalloproteinase Cocktail from the Venom of Protobothrops flavoviridis Cleaves Amyloid Beta Peptides at the α-Cleavage Site

Toxins, 2023
A disintegrin and metalloproteinase (ADAM) family proteins are a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell surface protein ectodomains, including amyloid precursor protein (APP).
Eugene Futai, Hajime Kawasaki, Shinichi Sato, Khadija Daoudi, Masafumi Hidaka, Taisuke Tomita, Tomohisa Ogawa   +6 more
doaj   +1 more source

FATCAT 2.0: towards a better understanding of the structural diversity of proteins

Nucleic Acids Res., 2020
FATCAT 2.0 server (http://fatcat.godziklab.org/), provides access to a flexible protein structure alignment algorithm developed in our group. In such an alignment, rotations and translations between elements in the structure are allowed to minimize the ...
Zhan-Wen Li, L. Jaroszewski, Mallika Iyer, Mayya Sedova, A. Godzik   +4 more
semanticscholar   +1 more source

Characterization of Mammalian ADAM2 and Its Absence from Human Sperm. [PDF]

PLoS ONE, 2016
The members of the ADAM (a disintegrin and metalloprotease) family are membrane-anchored multi-domain proteins that play prominent roles in male reproduction.
Heejin Choi, Sora Jin, Jun Tae Kwon, Jihye Kim, Juri Jeong, Jaehwan Kim, Suyeon Jeon, Zee Yong Park, Kang-Jin Jung, Kwangsung Park, Chunghee Cho   +10 more
doaj   +1 more source

Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State

Membranes, 2022
A disintegrin and metalloproteinase 15 (ADAM15) is a member of the ADAM family of sheddases. Its genetic ablation in mice suggests that ADAM15 plays an important role in a wide variety of biological functions, including cartilage homeostasis ...
Chun-Yao Yang, Simone Bonelli, Matteo Calligaris, Anna Paola Carreca, Stephan A. Müller, Stefan F. Lichtenthaler, Linda Troeberg, Simone D. Scilabra   +7 more
doaj   +1 more source

Role of ADAM and ADAMTS Disintegrin and Metalloproteinases in Normal Pregnancy and Preeclampsia.

Biochemical Pharmacology, 2022
Normal pregnancy (NP) involves intricate processes starting with egg fertilization, proceeding to embryo implantation, placentation and gestation, and culminating in parturition.
Hong-Mei Qu, R. Khalil
semanticscholar   +1 more source

A Disintegrin and Metalloproteinase (ADAM) Family—Novel Biomarkers of Selected Gastrointestinal (GI) Malignancies?

Cancers, 2022
Simple Summary A disintegrin and metalloproteinase (ADAM) proteins are proteolytic enzymes that are responsible for destroying the extracellular matrix, but they also have adhesive properties.
M. Łukaszewicz-Zając, Sara Pączek, B. Mroczko   +2 more
semanticscholar   +1 more source

ADAM and ADAMTS Disintegrin and Metalloproteinases as Major Factors and Molecular Targets in Vascular Malfunction and Disease

Advances in Pharmacology, 2022
A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) are two closely related families of proteolytic enzymes.
Hai-kun Yang, R. Khalil
semanticscholar   +1 more source

Correlation Between A Disintegrin and Metalloproteinase (ADAM) Family Proteins (8, 10, 17, 22) and Link with Neuroplasticity in Autism Spectrum Disorder

Current Issues in Molecular Biology
Background: Autism spectrum disorder (ASD) is a condition related to neurodevelopment, typically identified by impaired social interactions and repetitive stereotypical behaviors.
Dost Muhammad Halepoto, Laila Al-Ayadhi, Abdulrahman Alhowikan, Nadra Elamin, Durria Abdulmaged, Aurangzeb Halepota, Sarah Al-Mazidi   +6 more
doaj   +1 more source

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase [PDF]

Journal of Biological Chemistry, 2009
ADAM10 is involved in the proteolytic processing and shedding of proteins such as the amyloid precursor protein (APP), cadherins, and the Notch receptors, thereby initiating the regulated intramembrane proteolysis (RIP) of these proteins. Here, we demonstrate that the sheddase ADAM10 is also subject to RIP.
Tousseyn, T, Thathiah, A, Jorissen, E, Raemaekers, T, Konietzko, U, Reiss, K, Maes, E, Snellinx, A, Serneels, L, Nyabi, O, Annaert, W, Saftig, P, Hartmann, D, De Strooper, B   +13 more
openaire   +2 more sources

Identification of ADAM 31: A Protein Expressed in Leydig Cells and Specialized Epithelia* [PDF]

Endocrinology, 2000
A family of proteins containing a disintegrin and metalloproteinase domain (ADAMs) has been identified recently. Here, we report the identification of a novel member of the ADAM protein family from mouse. This protein is designated ADAM 31. The complementary DNA sequence of ADAM 31 predicts a transmembrane protein with metalloproteinase, disintegrin ...
L, Liu, J W, Smith
openaire   +2 more sources