Results 51 to 60 of about 12,483 (230)
, 2017 Inelastic Neutron Scattering spectrum of Adamantane, C₁₂H₁₆, measured on the TFXA ...
J.Tomkinson, ISIS
core +1 more source
Emergence and Fixing of Antiviral Resistance in Influenza A Via Recombination and Hitch Hiking [PDF]
, 2009 The dramatic rise of oseltamivir resistance in the H1N1 serotype in the 2007/2008 season and the fixing of H274Y in the 2008/2009 season has raised concerns regarding individuals at risk for seasonal influenza, as well as development of similar ...
Henry L. Niman
core
Confined adamantane molecules assembled to one dimension in carbon nanotubes [PDF]
, 2011 We have encapsulated adamantane (C10H16) in single- and multi-walled carbon nanotubes. Adamantane is a high symmetry cage like molecule with point group symmetry Td and can be considered as a hydrogen-terminated diamond fragment.
Nitze, Florian, +20 more
core +1 more source
Advanced Science, EarlyView.This study presents a computational tunnel engineering strategy in Fe(II)/α‐ketoglutarate‐dependent dioxygenases (αKGDs) to enhance oxygen (O2) transport, an essential molecule for αKGDs, and limit hydrogen peroxide (H2O2) entry, an inhibitor from the αKG supply system.
Huan Liu +10 more
wiley +1 more source
Synthesis of Adamantane Derivatives. III. Synthesis of Adamantane Heterocycles [PDF]
Bulletin of the Chemical Society of Japan, 1969 Abstract Preparation of 1-adamantyl and adamantane-1-carbonyl derivatives having benzimidazole, 1,3,5-oxadiazole, oxazoline-2, quinoxaline, 2-aminothiazole, thiazolone, 2-methylthiazole, 1,2,3-thiadiazole, pyrazole or pyrazoline ring is described.
Tadashi Sasaki +2 more
openaire +1 more source
Molecules, 2022 Inhibiting tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising strategy for increasing the effectiveness of existing antitumor therapy since it can remove the DNA lesions caused by anticancer drugs, which form covalent complexes with topoisomerase 1 ...
Aldar A. Munkuev +13 more
doaj +1 more source
Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics
Advanced Intelligent Discovery, EarlyView.A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha +2 more
wiley +1 more source
Novel 1,4-Disubstituted Adamantane Stereoisomers: Synthesis and Spectroscopic Characterization [PDF]
, 2004 A series of new 1,4-disubstituted adamantane derivatives [e.g., 1-chloro-4-(carbethoxymethylene) adamantane (3), 1-chloro-4-(carbethoxymethyl)adamantane (4), 1-chloro-4-(2-hydroxyethyl) adamantane (5), 1-chloro-4-(2-bromoethyl)adamantane (6), 1-bromo-4 ...
Mlinarić-Majerski, Kata +2 more
core +1 more source
Advanced Science, 2021 Dynamic and reversible assembly of molecules is ubiquitous in the hierarchical superstructures of living systems and plays a key role in cellular functions.
Alexandra N. Edelbrock +8 more
doaj +1 more source
Low prevalence of influenza A strains with resistance markers in Brazil during 2017–2019 seasons
Frontiers in Public Health, 2022 The influenza A virus (IAV) is of a major public health concern as it causes annual epidemics and has the potential to cause pandemics. At present, the neuraminidase inhibitors (NAIs) are the most widely used anti-influenza drugs, but, more recently, the
Thiago das Chagas Sousa +20 more
doaj +1 more source