Results 211 to 220 of about 5,511,471 (226)

Therapeutic Plasma Exchange in a Rare Case of Metastatic Pancreatic Carcinoma Presenting as Thrombotic Microangiopathy and Acute Kidney Injury. [PDF]

Cureus
Mok TH, Cheung CY.
europepmc   +1 more source

Modeling ANKRD26 5'-UTR mutation-related thrombocytopenia.

Dis Model Mech
Zheng L, Wu Z, Yada N, Liu S, Lin C, Bignotti A, Zhao X, Zheng XL.   +7 more
europepmc   +1 more source

[Effect of Recombinant Protein in the Spacer Domain on ADAMTS13 Activity].

Zhongguo shi yan xue ye xue za zhi, 2019
To obtain the recombinant protein of spacer domain in von Willebrand factor cleaving protease (ADAMTS13), and further study its biological function in ADAMTS13.The prokaryotic expression vector was constructed by using the template of plasmid with full-length ADAMTS13, and then transfected into E coli., following the induction of IPTG with the low ...
Fei Shen, Jie Yin, Changgeng Ruan, Jian Su, Zhenni Ma, Jing Ling, Li-Qian Xie   +6 more
semanticscholar   +5 more sources

Hematocrit and C‐reactive protein predict treatment response times in ADAMTS13‐deficient thrombotic microangiopathy

Journal of Clinical Apheresis, 2011
AbstractThrombotic microangiopathy (TMA) syndromes are a heterogeneous group of microvascular syndromes that are typically treated with plasma exchange and other adjunctive therapies. Important pathogenic factors, such as ADAMTS13 deficiency, define distinct subsets of TMA.
Noelle I. Samia, Kenneth D. Friedman, Jerome L. Gottschall, Thomas J. Raife   +3 more
semanticscholar   +5 more sources

Simvastatin Improve ADAMTS13 mRNA and Protein Expression in Podocytes.

Blood, 2012
Abstract Abstract 2246 Aim: ADAMTS13 is a specific VWF (von Willebrand factor) -cleaving protease, which severe deficiency is the main cause of thrombotic thrombocytopenic purpura. ADAMTS13 is mainly synthesized and released of the surface of hepatic stellate cells and endothelial cells,
Ningzheng Dong, Lei Shen, Guoyuan Lu, Zhenni Ma, Changgeng Ruan   +4 more
semanticscholar   +4 more sources

Inverse correlations between serum ADAMTS13 levels and systolic blood pressure, pulse pressure, and serum C-reactive protein levels observed at a general health examination in a Japanese population: A cross-sectional study

Clinica Chimica Acta, 2013
Although a defect in ADAMTS13 activity is known to cause platelet thrombosis resulting in thrombotic thrombocytopenic purpura (TTP), recent evidence has revealed that low plasma ADAMTS13 concentrations may increase the risk of ischemic vascular diseases.
Tomoko Ono, Tsutomu Yamazaki, Hitoshi Ikeda, Yutaka Yatomi, Haruhiko Yoshida, Toru Suzuki, Kenichiro Enooku, Reiko Kato, Yukio Kume, Kenichi Aizawa, Makoto Kurano   +10 more
semanticscholar   +5 more sources

Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation

Heart and Vessels, 2008
The aim of the present study is to clarify the roles of circulating ADAMTS13 and von Willebrand factor (VWF) in the formation of coronary artery thrombi in acute myocardial infarction (AMI). Twenty-six AMI patients, 37 age-matched healthy controls, and 20 young controls were studied.
Hiromichi Ishizashi, Manabu Horii, Tamio Nakajima, Masahito Uemura, Masanori Matsumoto, Keiichi Imagawa, Yukiji Takeda, Yoshihiko Saito, Shiro Uemura, Yoshihiro Fujimura, Hiroyuki Kawata, Hajime Iwama   +11 more
semanticscholar   +4 more sources

High-Throughput Screening of a Large Combinatorial Library of Small Proteins Against Human Spleen-Derived Monoclonal Anti-ADAMTS13 Antibodies Yields Specific Anti-Idiotypic Molecules – Potential Tools for New Treatment Strategy in Acquired TTP

Blood, 2012
Abstract Abstract 487 Background. Acquired Thrombotic Thrombocytopenic Purpura (TTP) is the result of autoantibodies (Abs) neutralizing and/or accelerating clearance of ADAMTS13. Despite the first-line treatment with daily plasma exchange (PEX), acute TTP is still associated with a ...
Monica Schaller, Bernhard Laemmle, Sabine Hiltbrunner, Karim Kentouche, Monique Vogel, Irmela Sulzer, Johanna A. Kremer Hovinga   +6 more
openaire   +3 more sources

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Evaluating von Willebrand factor and ADAMTS13 levels in thalassemia major patients and assessing a possible association with Thrombospondin‐1

International Journal of Laboratory Hematology, 2023
Alterations in the endothelium and endothelial adhesion proteins such as von Willebrand factor (vWF) play major roles in hypercoagulability in thalassemia.
Kefayah Al-Sabaan, A. Al-Awadhi
semanticscholar   +1 more source

Identify the influences of systemic lupus erythematosus on acquired ADAMTS13-deficient thrombotic thrombocytopenic purpura using comprehensive bioinformatics analysis

Lupus, 2023
Background The association between acquired ADAMTS13-deficient thrombotic thrombocytopenic purpura (aTTP) and systemic lupus erythematosus (SLE) has been studied; however, the underlying molecular causes remain poorly understood.
Jian Zhang
semanticscholar   +1 more source