Results 1 to 10 of about 9,301 (216)
Pathogenicity of Anti-ADAMTS13 Autoantibodies in Acquired Thrombotic Thrombocytopenic Purpura
EBioMedicine, 2015 Background: Acquired thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease in which anti-ADAMTS13 autoantibodies cause severe enzyme deficiency.
Rens De Groot +2 more
exaly +3 more sources
AFM Imaging Reveals Multiple Conformational States of ADAMTS13 [PDF]
Journal of Biological Engineering, 2019 Background ADAMTS13 (A disintegrin and metalloprotease with a thrombospondin type 1 motif 13) cleaves Von Willebrand factor (VWF) to regulate its size, thereby preventing aberrant platelet aggregation and thrombus. Deficiency of ADAMTS13 caused by either
Shanshan Yu +6 more
doaj +2 more sources
Phenotypic expression of ADAMTS13 in glomerular endothelial cells. [PDF]
PLoS ONE, 2011 BackgroundADAMTS13 is the physiological von Willebrand factor (VWF)-cleaving protease. The aim of this study was to examine ADAMTS13 expression in kidneys from ADAMTS13 wild-type (Adamts13⁺/⁺) and deficient (Adamts13⁻/⁻) mice and to investigate the ...
Ramesh Tati +8 more
doaj +3 more sources
Characterization of ADAMTS13 and von Willebrand factor levels in septic and non-septic ICU patients.
PLoS ONE, 2021 Sepsis is a life-threatening disease characterized by excessive host response to infection that can lead to activation of the coagulation system. Von Willebrand Factor (VWF) and ADAMTS13 are important regulators of hemostasis and their dysregulation ...
Kanwal Singh +7 more
doaj +1 more source
Biology, 2023 Acute-on-chronic liver failure (ACLF) has a high risk of short-term mortality. A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) is a metalloproteinase that specifically cleaves multimeric von Willebrand factor (VWF)
Hiroaki Takaya +12 more
doaj +1 more source
Role of ADAMTS13, VWF and F8 genes in deep vein thrombosis.
PLoS ONE, 2021 BackgroundWe previously described the association between rare ADAMTS13 single nucleotide variants (SNVs) and deep vein thrombosis (DVT). Moreover, DVT patients with at least one rare ADAMTS13 SNV had a lower ADAMTS13 activity than non-carriers.AimsTo ...
Maria Teresa Pagliari +8 more
doaj +2 more sources
Platelets, 2023 ADAMTS13 is a plasma metalloprotease with the primary function of cleaving VWF to maintain hemostasis. Circulating ADAMTS13 is in the closed conformation until blood vessel injury triggers a VWF-dependant activation to the open active form of the protein.
Zoe Markham-Lee +2 more
doaj +1 more source
TH Open, 2018 A diagnosis of thrombotic thrombocytopenic purpura (TTP) is confirmed by a severe deficiency (
Chiara Vendramin +3 more
doaj +1 more source
Diagnosis of thrombotic thrombocytopenic purpura
Терапевтический архив, 2020 Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease, disease, characterised by microangiopathic hemolytic anaemia, consumption thrombocytopenia, and organ dysfunction.
G. M. Galstyan, E. E. Klebanova
doaj +1 more source
The class I scavenger receptor CD163 promotes internalization of ADAMTS13 by macrophages
Blood Advances, 2017 : Internalization of ADAMTS13 by macrophages may contribute to its clearance from the circulation. Here we investigated endocytic mechanisms that contribute to the uptake of ADAMTS13 by macrophages. Human monocyte-derived macrophages were used to monitor
Fabian C. Verbij +12 more
doaj +1 more source