Results 41 to 50 of about 14,009 (226)

Persistence of circulating ADAMTS13-specific immune complexes in patients with acquired thrombotic thrombocytopenic purpura

Haematologica, 2014
Anti-ADAMTS13 autoantibodies are the main cause of acquired thrombotic thrombocytopenic purpura. Binding of these antibodies to ADAMTS13 eventually results in the formation of antigen-antibody immune complexes.
Silvia Ferrari, Kristina Palavra, Bernadette Gruber, Johanna A. Kremer Hovinga, Paul Knöbl, Claudine Caron, Caroline Cromwell, Louis Aledort, Barbara Plaimauer, Peter L. Turecek, Hanspeter Rottensteiner, Friedrich Scheiflinger   +11 more
doaj   +1 more source

Reduced ADAMTS13 Activity in Correlation with Pathophysiology, Severity, and Outcome of COVID-19: A Retrospective Observational Study

International Journal of Infectious Diseases, 2022
Background: Low ADAMTS13 activity has been suggested to be an interplaying factor in the pathogenesis of COVID-19, considering that it is a thromboinflammatory disease with high risk of microthrombosis.
Wael Hafez, Mohamad Azzam Ziade, Arun Arya, Husam Saleh, Sara Ali, Srinivasa Raghu Rao, Osman Fdl Alla, Mohamed Ali, Mouhamad Al Zouhbi, Ahmed Abdelrahman   +9 more
doaj   +1 more source

ADAMTS13 in pediatric sepsis: a prognostic biomarker with potential therapeutic implications

Egyptian Pediatric Association Gazette, 2023
Background Growing evidence implicates a pro-thrombotic state, caused by ADAMTS13 deficiency, in sepsis-associated organ dysfunction, but pediatric data is limited.
Muhammad Said El-Mekkawy, Sara Mahmoud El-Deeb, Maha Fawzy El-Hanafy   +2 more
doaj   +1 more source

Elevated plasma neutrophil elastase concentration is associated with disease activity in patients with thrombotic thrombocytopenic purpura. [PDF]

, 2015
INTRODUCTION: Genetic and autoimmune risk factors contribute to the development of thrombotic thrombocytopenic purpura (TTP) but triggers are needed to bring about acute disease.
Brill, Brinkmann, Brinkmann, Bálint Mikes, Chapman, Chaturvedi, Chen, Clark, Clark, Derzsy, Dorottya Csuka, Falter, Fitzpatrick, Fuchs, Fujimura, Gombos, Gyula Domján, György Sinkovits, Hung, Ishikawa, Jagels, Judit Demeter, Karpman, Katalin Rázsó, Kessenbrock, Kremer Hovinga, Leffler, Marienn Réti, Massberg, Moatti-Cohen, Noris, Papayannopoulos, Peng, Peyvandi, Péter Farkas, Raife, Reti, Tsai, Urban, van Montfoort, Walters, Westwood1, Xu, Zoltán Prohászka, Ágota Schlammadinger   +44 more
core   +1 more source

Anti-ADAMTS13 Antibodies and a Novel Heterozygous p.R1177Q Mutation in a Case of Pregnancy-Onset Immune-Mediated Thrombotic Thrombocytopenic Purpura

TH Open, 2018
In this study, we investigated a case of pregnancy-onset thrombotic thrombocytopenic purpura (TTP). The patient had severely decreased ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13) activity levels during acute ...
Elien Roose, Claudia Tersteeg, Ruth Demeersseman, An-Sofie Schelpe, Louis Deforche, Inge Pareyn, Aline Vandenbulcke, Nele Vandeputte, Daan Dierickx, Jan Voorberg, Hans Deckmyn, Simon F. De Meyer, Karen Vanhoorelbeke   +12 more
doaj   +1 more source

Evidence for a role of anti-ADAMTS13 autoantibodies despite normal ADAMTS13 activity in recurrent thrombotic thrombocytopenic purpura

Haematologica, 2012
Background Severe ADAMTS13 deficiency is a critical component of the pathogenesis of idiopathic thrombotic thrombocytopenic purpura but is found only in about 60% of patients clinically diagnosed with this disease.Design and Methods Over a period of 8 ...
Rahel Froehlich-Zahnd, James N. George, Sara K. Vesely, Deirdra R. Terrell, Khatira Aboulfatova, Jing-Fei Dong, Brenda M. Luken, Jan Voorberg, Ulrich Budde, Irmela Sulzer, Bernhard Lämmle, Johanna A. Kremer Hovinga   +11 more
doaj   +1 more source

Von Willebrand Factor, ADAMTS13 and D-Dimer Are Correlated with Different Levels of Nephropathy in Type 1 Diabetes Mellitus. [PDF]

PLoS ONE, 2015
We have investigated whether von Willebrand factor, ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13), and D-Dimer were associated with different levels of renal function in patients with type 1 diabetes. Patients
Caroline Pereira Domingueti, Luci Maria S Dusse, Rodrigo Bastos Fóscolo, Janice Sepúlveda Reis, Joyce Maria Annichino-Bizzacchi, Fernanda Loureiro de Andrade Orsi, Bruna de Moraes Mazetto, Maria das Graças Carvalho, Karina Braga Gomes, Ana Paula Fernandes   +9 more
doaj   +1 more source

Factor XI/ADAMTS13 complexes are quantitatively insignificant in human plasma [PDF]

, 2007
Reportedly, complexes between factor XI and ADAMTS13 are detected with a commercial ADAMTS13/FXI ELISA kit in plasma and are decreased in thrombotic thrombocytopenic purpura (TTP).
Anderson, Patricia J, Feys, Hendrik B, Gailani, David, Gao, Weiqiang, Majerus, Elaine M, Sadler, J. Evan, Vanhoorelbeke, Karen   +6 more
core   +2 more sources

Internal tension in a collapsed polymer under shear flow and the connection to enzymatic cleavage of von Willebrand factor [PDF]

, 2016
By means of Brownian hydrodynamics simulations we show that the tension distribution along the contour of a single collapsed polymer in shear flow is inhomogeneous and above a threshold shear rate exhibits a double-peak structure when hydrodynamic ...
Lippok, Svenja, Netz, Roland, Radtke, Matthias, Rädler, Joachim O.   +3 more
core   +2 more sources

Disease Remission: A Scoping Review With Thematic Analysis of the Scientific Literature With Implications for Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Remission, a term used to describe a goal of treatment for some chronic diseases, has recently been proposed for chronic rhinosinusitis (CRS). However, it is unclear what remission means for CRS and why it should serve as a goal in the present‐day treatment of CRS.
Nikhil Parail, Lynn Warner, Stacey T. Gray, Claire Hopkins, Peter H. Hwang, Sarah K. Wise, Katie M. Phillips, Ahmad R. Sedaghat   +7 more
wiley   +1 more source