Results 21 to 30 of about 9,301 (216)
Levels of von Willebrand factor antigen and von Willebrand factor cleaving protease (ADAMTS13) activity predict clinical events in chronic heart failure. [PDF]
, 2009 Decreased activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease, was recently reported in cardiovascular diseases and in hepatic failure.
Borgulya, Gábor +10 more
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ADAMTS13 activity and inhibitor [PDF]
American Journal of Hematology, 2008 AbstractThrombotic thrombocytopenic purpura (TTP) is often associated with acquired or congenital deficiency of the von Willebrand factor‐cleaving metalloprotease, ADMATS13 (Lammle B et al., J Thromb Haemost 2005;3:1663‐1675; Schneppenheim et al., Blood 2003;101:1845‐1850).
Adriana, Doldan-Silvero +4 more
openaire +2 more sources
A phenotype–genotype correlation of ADAMTS13 mutations in congenital thrombotic thrombocytopenic purpura patients treated in the United Kingdom [PDF]
, 2012 Background: ADAMTS13 mutations play a role in thrombotic thrombocytopenic purpura (TTP) pathogenesis. Objectives: To establish a phenotype–genotype correlation in a cohort of congenital TTP patients.
Machin, S.J. +7 more
core +1 more source
ADAMTS13 activity in sickle cell disease [PDF]
, 2006 Sickle red blood cell (SRBC)-endothelial adhesion plays a central role in sickle cell disease (SCD)-related vaso-occlusion. As unusually large von Willebrand factor (ULVWF) multimers mediate SRBC-endothelial adhesion, we investigated the activity of ...
Krieg, S +9 more
core +1 more source
Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients
Scientific Reports, 2021 A mild decrease of ADAMTS13 (a disintegrin and metalloprotease with thrombospodin type 1 motif 13) could attribute to stroke and coronary heart disease in general population.
Shih-Yuan Hung +9 more
doaj +1 more source
Mechanism of ADAMTS13 regulation [PDF]
, 2022 Studies demonstrated ADAMTS13 possesses unique properties with a mystifying regulatory mechanism. ADAMTS13’s role is in its proteolytic function to its VWF.
Madarati, Hasam
core
ADAMTS13 and microvascular thrombosis [PDF]
Expert Review of Cardiovascular Therapy, 2006 Interaction between platelet and von Willebrand factor, a circulating adhesive glycoprotein, is essential for hemostasis under the high shear environments of arterioles and capillaries. If unregulated, this interaction may lead to unwarranted platelet thrombosis.
openaire +2 more sources
Mechanistic Studies on ADAMTS13 Catalysis [PDF]
Biophysical Journal, 2008 The zinc-protease a disintegrin-like and metalloprotease with thrombospondin type I repeats (ADAMTS13) cleaves the Tyr(1605)-Met(1606) peptide bond of von Willebrand factor (VWF), avoiding the accumulation of ultra large VWF multimers. Hydrolysis by ADAMTS13 of a VWF analog (Asp(1596)-Arg(1668) peptide, fluorescence energy transfer substrate [FRETS ...
Di Stasio, Enrico +5 more
openaire +4 more sources
Role of ADAMTS13 in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura [PDF]
, 2012 The regulation of VWF multimer size is essential in preventing spontaneous microvascular platelet clumping, a central pathophysiologic finding in thrombotic thrombocytopenic purpura (TTP).
Kremer Hovinga, Johanna A +1 more
core +1 more source
Thrombosis Journal, 2017 Background The mechanisms behind residual platelet reactivity (RPR) despite aspirin treatment are not established. It has been shown that coronary artery disease (CAD) patients with high on-aspirin RPR have elevated levels of von Willebrand factor (vWF).
Ellen M. K. Warlo +3 more
doaj +1 more source