Results 31 to 40 of about 14,009 (226)

ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study [PDF]

, 2016
Aims/hypothesis: ADAMTS13 is a protease that breaks down von Willebrand factor (VWF) multimers into smaller, less active particles. VWF has been associated with an increased risk of incident type 2 diabetes mellitus.
Dehghan, A. (Abbas), Franco, O.H. (Oscar), Herpt, T.W. (Thijs) van, Hoek, M. (Mandy) van, Hofman, A. (Albert), Ikram, M.A. (Arfan), Leebeek, F.W.G. (Frank), Ligthart, S. (Symen), Maat, M.P.M. (Moniek) de, Sijbrands, E.J.G. (Eric), Vries, P.S. (Paul) de   +10 more
core   +4 more sources

Disappearing acts of ADAMTS13

EBioMedicine, 2015
The study by Thomas and co-workers in this issue of EBioMedicine provides detailed characteristics on the pathogenic properties of antibodies that develop in patients with acquired thrombotic thrombocytopenic purpura (TTP) (Thomas et al., 2015). It is now well-established that TTP is due to dysregulation of primary hemostasis. A crucial initial step in
Voorberg, Jan, Verbij, Fabian C., Fijnheer, Rob   +2 more
openaire   +4 more sources

Degradation of two novel congenital TTP ADAMTS13 mutants by the cell proteasome prevents ADAMTS13 secretion [PDF]

, 2016
INTRODUCTION: Over 150 mutations have been identified in the ADAMTS13 gene in patients with congenital thrombotic thrombocytopenic purpura (TTP). The majority of these (86%), lead to reduced (
Garagiola, I, Machin, S, Mackie, I, Peyvandi, F, Underwood, M   +4 more
core   +1 more source

Glycans of plasma ADAMTS13 [PDF]

Blood, 2016
In this issue of Blood , [Verbij et al][1] identified the sites of glycosylation in plasma ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) and determined the composition of the glycan structures at these sites.[1][2] ADAMTS13 is a blood enzyme ...
openaire   +2 more sources

Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia [PDF]

, 2018
Low ADAMTS13 activity is associated with an increased risk of cardiovascular disease, which is generally attributed to its proteolytic effects on Von Willebrand factor (VWF). Cardiovascular health is an important determinant of cognitive decline, but the
Boender, J. (Johan), Franco, O.H. (Oscar), Ikram, M.A. (Arfan), Ikram, M.K. (Kamran), Koudstaal, P.J. (Peter), Leebeek, F.W.G. (Frank), Maat, M.P.M. (Moniek) de, Sonneveld, M.A.H. (Michelle), Vries, P.S. (Paul) de, Wolters, F.J. (Frank)   +9 more
core   +1 more source

ADAMTS13, TTP and Beyond [PDF]

Hereditary Genetics, 2013
Copyright: © 2012 Zheng XL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
openaire   +2 more sources

Perinatal Gene Transfer to the Liver [PDF]

, 2011
The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within
Buckley, SM, Chan, JK, Howe, SJ, McKay, TR, Rahim, AA, Waddington, SN, Ward, NJ   +6 more
core   +1 more source

ADAMTS13 activity and antigen during therapy and follow-up of patients with idiopathic thrombotic thrombocytopenic purpura: correlation with clinical outcome

Haematologica, 2011
Background The assay for ADAMTS13 activity helps clinicians to confirm the clinical diagnosis of idiopathic thrombotic thrombocytopenic purpura. The clinical value of testing for the antigen level of ADAMTS13 protein is, however, less clear.Design and ...
Shangbin Yang, Ming Jin, Shili Lin, Spero Cataland, Haifeng Wu   +4 more
doaj   +1 more source

ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis

Journal of Neuroinflammation, 2020
Background ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13) plays a vital role in preventing microvascular thrombosis and inflammation.
Kaili Lu, Lan Liu, Xiaofeng Xu, Fei Zhao, Jiangshan Deng, Xin Tang, Xiuzhe Wang, Bing-Qiao Zhao, Xiaojie Zhang, Yuwu Zhao   +9 more
doaj   +1 more source

Plasma von Willebrand factor levels predict in-hospital survival in patients with acute-on-chronic liver failure [PDF]

, 2016
BACKGROUND AND AIMS: Circulating levels of von Willebrand factor (vWF) predict mortality in patients with cirrhosis. We hypothesized that systemic inflammation in acute-on-chronic liver failure (ACLF) will stimulate endothelium, increase vWF levels, and ...
Amirtharaj, GJ, Balasubramanian, KA, Eapen, CE, Elias, E, Goel, A, Mackie, I, Prasanna, KS, Ramachandran, A, Sajith, KG, Zachariah, U   +9 more
core   +1 more source