Results 31 to 40 of about 9,301 (216)

Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions

Frontiers in Medicine, 2017
Platelet recruitment to sites of vascular injury is mediated by von Willebrand factor (VWF). The shear-induced unraveling of ultra-large VWF multimers causes the formation of a “stringlike” conformation, which rapidly recruits platelets from the ...
Kathleen S. Garland, Kathleen S. Garland, Stéphanie E. Reitsma, Stéphanie E. Reitsma, Toshiaki Shirai, Jevgenia Zilberman-Rudenko, Erik I. Tucker, Erik I. Tucker, David Gailani, András Gruber, András Gruber, Owen J. T. McCarty, Cristina Puy   +12 more
doaj   +1 more source

Reduced ADAMTS13 levels in patients with acute and chronic cerebrovascular disease. [PDF]

PLoS ONE, 2017
Von Willebrand Factor (VWF) plays a major role in thrombosis and hemostasis and its thrombogenicity is controlled by ADAMTS13. Whereas increasing evidence shows a clear association between VWF levels and acute ischemic stroke, little is known about a ...
Frederik Denorme, Peter Kraft, Inge Pareyn, Christiane Drechsler, Hans Deckmyn, Karen Vanhoorelbeke, Christoph Kleinschnitz, Simon F De Meyer   +7 more
doaj   +1 more source

Disappearing acts of ADAMTS13

EBioMedicine, 2015
The study by Thomas and co-workers in this issue of EBioMedicine provides detailed characteristics on the pathogenic properties of antibodies that develop in patients with acquired thrombotic thrombocytopenic purpura (TTP) (Thomas et al., 2015). It is now well-established that TTP is due to dysregulation of primary hemostasis. A crucial initial step in
Voorberg, Jan, Verbij, Fabian C., Fijnheer, Rob   +2 more
openaire   +4 more sources

Humoral immune response to ADAMTS13 in acquired thrombotic thrombocytopenic purpura [PDF]

, 2011
The apparently spontaneous development of autoantibodies to ADAMTS13 in previously healthy individuals is a major cause of thrombotic thrombocytopenic purpura (TTP). Epitope mapping studies have shown that in most patients antibodies directed towards the
Hovinga, J A Kremer, Voorberg, J, Sorvillo, N, W. POS, Luken, B M, J.A. KREMER HOVINGA, Pos, W, B.M. LUKEN, N. SORVILLO, J. VOORBERG   +9 more
core   +1 more source

Glycans of plasma ADAMTS13 [PDF]

Blood, 2016
In this issue of Blood , [Verbij et al][1] identified the sites of glycosylation in plasma ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) and determined the composition of the glycan structures at these sites.[1][2] ADAMTS13 is a blood enzyme ...
openaire   +2 more sources

ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis

Journal of Neuroinflammation, 2020
Background ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13) plays a vital role in preventing microvascular thrombosis and inflammation.
Kaili Lu, Lan Liu, Xiaofeng Xu, Fei Zhao, Jiangshan Deng, Xin Tang, Xiuzhe Wang, Bing-Qiao Zhao, Xiaojie Zhang, Yuwu Zhao   +9 more
doaj   +1 more source

ADAMTS13, TTP and Beyond [PDF]

Hereditary Genetics, 2013
Copyright: © 2012 Zheng XL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
openaire   +2 more sources

Novel ADAMTS13 mutations in an obstetric patient with upshaw-schulman syndrome [PDF]

, 2013
Upshaw-Schulman syndrome (USS) is a rarely reported congenital form of thrombotic thrombocytopenic purpura (TTP) that results from mutations in the ADAMTS13 gene.
Johanna A. Kremer Hovinga, Jill Adamski, Taylor Deal, Deal, Taylor, Marisa B. Marques, Kremer Hovinga, Johanna A., Marques, Marisa B., Adamski, Jill   +7 more
core   +1 more source

Optimization of the detection of inhibitory autoantibodies against the VWF-cleaving protease ADAMTS13 with an automated chemiluminescent ADAMTS13 activity immunoassay [PDF]

, 2021
INTRODUCTION: Acquired thrombotic thrombocytopenic purpura is a rare disease associated with the production of autoantibodies against the VWF-cleaving protease ADAMTS13.
Toelen, Jelle, Debasse, Mirjam, Kathelijne Peerlinck, Jacquemin, Marc, Van Laer, Christine, Schoeters, Joke, Ingrid Vanlinthout, Vanlinthout, Ingrid, Marc Jacquemin, Jelle Toelen, Van Horenbeeck, Isa, Joke Schoeters, Mirjam Debasse, Peerlinck, Kathelijne, Christine Van Laer, Isa Van Horenbeeck, Dierickx, Daan, Daan Dierickx   +17 more
core   +1 more source

Anti-ADAMTS13 Antibodies and a Novel Heterozygous p.R1177Q Mutation in a Case of Pregnancy-Onset Immune-Mediated Thrombotic Thrombocytopenic Purpura

TH Open, 2018
In this study, we investigated a case of pregnancy-onset thrombotic thrombocytopenic purpura (TTP). The patient had severely decreased ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13) activity levels during acute ...
Elien Roose, Claudia Tersteeg, Ruth Demeersseman, An-Sofie Schelpe, Louis Deforche, Inge Pareyn, Aline Vandenbulcke, Nele Vandeputte, Daan Dierickx, Jan Voorberg, Hans Deckmyn, Simon F. De Meyer, Karen Vanhoorelbeke   +12 more
doaj   +1 more source