Results 61 to 70 of about 10,178 (166)

Diagnosis and follow‐up of thrombotic thrombocytopenic purpura with an automated chemiluminescent ADAMTS13 activity immunoassay

Research and Practice in Thrombosis and Haemostasis, 2021
Background Thrombotic thrombocytopenic purpura (TTP) is a life‐threatening thrombotic microangiopathy (TMA) caused by a severe functional deficiency in ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type I repeats‐13), the specific von ...
Nicolas Beranger, Sandrine Benghezal, Bérangère S. Joly, Sophie Capdenat, Adeline Delton, Alain Stepanian, Paul Coppo, Agnès Veyradier   +7 more
doaj   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Humoral immune response to ADAMTS13 in acquired thrombotic thrombocytopenic purpura

, 2011
The apparently spontaneous development of autoantibodies to ADAMTS13 in previously healthy individuals is a major cause of thrombotic thrombocytopenic purpura (TTP). Epitope mapping studies have shown that in most patients antibodies directed towards the
Hovinga, J A Kremer, Voorberg, J, Sorvillo, N, W. POS, Luken, B M, J.A. KREMER HOVINGA, Pos, W, B.M. LUKEN, N. SORVILLO, J. VOORBERG   +9 more
core   +1 more source

Application of PLASMIC Score in Risk Prediction of Thrombotic Thrombocytopenic Purpura: Real-World Experience From a Tertiary Medical Center in Taiwan

Frontiers in Medicine, 2022
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder caused by severe ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency (activity <10%).
Chun-Hui Lee, Chun-Hui Lee, Chun-Hui Lee, Yi-Ching Huang, Yi-Ching Huang, Sin-Syue Li, Sin-Syue Li, Ya-Ting Hsu, Ya-Ting Hsu, Ya-Ping Chen, Tsai-Yun Chen, Tsai-Yun Chen   +11 more
doaj   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source

Plasma ADAMTS13 activity in healthy dogs and dogs with chronic enteropathy

Journal of Small Animal Practice, EarlyView.
Objectives A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 is a von Willebrand factor cleaving enzyme that is associated with prothrombotic/hypercoagulable states in humans. In people, A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity is reduced with inflammatory bowel disease ...
S. I. Barth, S. M. DeMonaco, B. J. Conner, P. B. S. Serpa, A. R. Wilkinson   +4 more
wiley   +1 more source

Two causes of COVID‐19‐related myocardial injury‐associated cardiogenic shock: Myocarditis and microvascular thrombosis

ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai, Hirohiko Aikawa, Yoshiaki Morita, Keiko Ohta‐Ogo, Teruo Noguchi   +4 more
wiley   +1 more source

New Insights Into Pathogenesis, Diagnostics, and Therapeutic Options for Canine Angiostrongylosis

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To provide a comprehensive overview of Angiostrongylus vasorum infection in dogs, with a particular emphasis on recent developments in the understanding of disease pathophysiology and an update on developments in diagnostic and therapeutic options.
Iris Elgueta, Daniel Lewis, Eric R. Morgan, Jenny Helm   +3 more
wiley   +1 more source

SNPs in ADAMTS13

, 2011
The multidomain metalloprotease ADAMTS13 limits thrombus formation via the cleavage of large multimeric forms of von Willebrand factor. Deficiency of functional ADAMTS13 is associated with a number of disease pathologies including thrombotic ...
Chava Kimchi-Sarfaty, Sandra Chang Tseng
core   +1 more source

Optimization of the detection of inhibitory autoantibodies against the VWF-cleaving protease ADAMTS13 with an automated chemiluminescent ADAMTS13 activity immunoassay

, 2021
INTRODUCTION: Acquired thrombotic thrombocytopenic purpura is a rare disease associated with the production of autoantibodies against the VWF-cleaving protease ADAMTS13.
Toelen, Jelle, Debasse, Mirjam, Kathelijne Peerlinck, Jacquemin, Marc, Van Laer, Christine, Schoeters, Joke, Ingrid Vanlinthout, Vanlinthout, Ingrid, Marc Jacquemin, Jelle Toelen, Van Horenbeeck, Isa, Joke Schoeters, Mirjam Debasse, Peerlinck, Kathelijne, Christine Van Laer, Isa Van Horenbeeck, Dierickx, Daan, Daan Dierickx   +17 more
core   +1 more source