Results 81 to 90 of about 10,178 (166)

The emerging concept of residual ADAMTS13 activity in ADAMTS13-deficient thrombotic thrombocytopenic purpura

, 2013
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease characterized by acute episodes of widespread microvascular thrombosis. The discovery that the plasmatic activity of the von Willebrand factor cleaving protease, ADAMTS13, is ...
H. M. Wu, L. A. Lotta, K. M. Musallam, F. Peyvandi   +3 more
core   +1 more source

Current advances in 2025: A critical review of selected topics by the Association for the Advancement of Blood and Biotherapies (AABB) Clinical Transfusion Medicine Committee

Transfusion, EarlyView.
Nabiha H. Saifee, Jennifer Andrews, Mary Berg, Stella T. Chou, Mischa Covington, Elizabeth P. Crowe, Ruchika Goel, Juliana A. Guarente, Tina Ipe, Jeremy W. Jacobs, Jessica Jacobson, Cyril Jacquot, Jenna Khan, Thane A. Kubik, Theodros Mamo, Michael F. Murphy, Kerry O'Brien, Monica B. Pagano, Anil K. Panigrahi, Jacqueline N. Poston, Scott E. Potter, Simon J. Stanworth, Moritz Stolla, Alyssa Ziman, Ryan A. Metcalf   +24 more
wiley   +1 more source

Anti-ADAMTS13 autoantibodies in immune-mediated thrombotic thrombocytopenic purpura do not hamper ELISA-based quantification of ADAMTS13 antigen

, 2020
BACKGROUND: The biological diagnosis of immune-mediated thrombotic thrombocytopenic purpura (iTTP) is based on determination of ADAMTS13 activity (
Tellier, Edwige, Feys, Hendrik B., Pareyn, Inge, Kaplanski, Gilles, Scully, Marie, Coppo, Paul, Vandenbulcke, Aline, Dekimpe, Charlotte, Deckmyn, Hans, Veyradier, Agnes, Dewaele, Aurelie, Horta, Sara, De Meyer, Simon F., Joly, Bérangère, Feys, Hendrik, Tersteeg, Claudia, Roose, Elien, Vanhoorelbeke, Karen, Joly, Berangere S., de Meyer, Simon   +19 more
core   +1 more source

Concentration and Subclass Distribution of Anti-ADAMTS13 IgG Autoantibodies in Different Stages of Acquired Idiopathic Thrombotic Thrombocytopenic Purpura

Frontiers in Immunology, 2018
BackgroundThe acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying deficiency of the ADAMTS13 protease is caused by autoantibodies, predominantly of the IgG isotype.
György Sinkovits, Ágnes Szilágyi, Péter Farkas, Dóra Inotai, Anikó Szilvási, Attila Tordai, Katalin Rázsó, Marienn Réti, Zoltán Prohászka   +8 more
doaj   +1 more source

Fatal congenital thrombotic thrombocytopenic purpura with apparent ADAMTS13 inhibitor: in vitro inhibition of ADAMTS13 activity by hemoglobin.

, 2005
Severe ADAMTS13 deficiency in thrombotic thrombocytopenic purpura (TTP) is either constitutional and caused by ADAMTS13 mutations, or acquired and most often due to ADAMTS13 inhibitory autoantibodies.
Rieger M, Hermann M, Antoine G, Studt JD, Scheiflinger F, Kremer Hovinga JA, Lämmle B   +6 more
core   +1 more source

Infection frequently triggers thrombotic microangiopathy in patients with preexisting risk factors : a single-institution experience [PDF]

, 2010
Thrombotic microangiopathies are rare conditions characterized by microangiopathic hemolytic anemia, microthrombi, and multiorgan insult. The disorders, which include hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, are often acute and ...
Douglas, K.W., Green, R., Douglas, Kenneth W., Pollock, K.G.J., Pollock, Kevin G.J., Catlow, Jamie, Young, D., Catlow, J., Young, David, Green, Rachel   +9 more
core   +1 more source

ADAMTS13 expression in mouse kidney.

, 2013
ADAMTS13 expression was investigated by immunohistochemistry in mouse renal tissue. Staining was observed in the kidney of Adamts13+/+ wild-type mice on the mixed 129X1/SvJ and C57BL/6 genetic background (Panel A).
David Motto (349293), Matthias Mörgelin (109607), Anne-lie Ståhl (349291), Minola Manea-Hedström (349298), Peter Mathieson (349296), Diana Karpman (67915), Ramesh Tati (349287), Simon Satchell (349295), Ann-Charlotte Kristoffersson (349289)   +8 more
core   +1 more source

VH1-69 germline encoded antibodies directed towards ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

, 2009
BACKGROUND: Autoantibodies directed towards ADAMTS13 are present in the majority of patients with acquired thrombotic thrombocytopenic purpura (TTP). Analysis of a set of antibodies derived from two patients with acquired TTP revealed frequent use of the
Luken, B M, Fijnheer, R, Luken, B. M., Kremer Hovinga, Johanna A., Hovinga, J A Kremer, Voorberg, J, Dong, J.-F., Fijnheer, R., Voorberg, J., Dong, J-F, Turenhout, E A M, Scheiflinger, F., Pos, W., Pos, W, Turenhout, E. A. M., Scheiflinger, F   +15 more
core   +1 more source

Characterisation of the ADAMTS13 Metalloprotease Domain [PDF]

, 2012
Von Willebrand Factor (VWF) is a large multi-domain plasma glycoprotein that is critical for normal platelet tethering during haemostasis. ADAMTS13 is a plasma metalloprotease that regulates VWF multimeric size/function by cleaving the Tyr1605-Met1606
Xiang, Yaozu
core   +1 more source

Three disintegrin-like domain mutations of ADAMTS13： functional deficiency and association with thrombosis [PDF]

Zhenduanxue lilun yu shijian
Objective To analyze the genotypic and phenotypic characteristics of four thrombotic patients carrying heterozygous mutations in the disintegrin-like domain of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs 13), and to ...
LIN Liya, WU Xi, MAO Yinqi, CHEN Guangming, WU Wenman, DAI Jing, WANG Xuefeng, DING Qiulan
doaj   +1 more source