Results 91 to 100 of about 9,301 (216)
ADAMTS13 assays in thrombotic microangiopathy [PDF]
, 2012 Thrombotic microangiopathy is featured by microangiopathic haemolytic anaemia, thrombocytopenia and the presence of peripheral fragmented red cells. Thrombotic thrombocytopenic purpura (TTP) is the major disease entity of concern, which is caused by a ...
Lam, Wang-hoi., 林宏凱.
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PLoS Neglected Tropical DiseasesBackgroundEnvenoming by Bothrops lanceolatus, a viperid endemic to Martinique an island in the Lesser Antilles, induces a unique clinical manifestation, i.e., thrombosis. Pathophysiological signaling leading to thrombotic events remains poorly understood.
Jonathan Florentin +8 more
doaj +1 more source
Frontiers in Immunology, 2018 BackgroundThe acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying deficiency of the ADAMTS13 protease is caused by autoantibodies, predominantly of the IgG isotype.
György Sinkovits +8 more
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The “5L” framework of diagnostic reasoning: A stepwise scaffold to support clinician educators
Journal of Hospital Medicine, Volume 21, Issue 6, Page 665-669, June 2026.Abstract Diagnostic reasoning (DR) is a core clinical skill, yet its teaching remains variable. We introduce the “5L” framework as a bedside teaching scaffold that gives educators and learners a shared, stepwise set of prompts for DR during individual encounters. By asking, “What's Lethal? What's Likely? What's Logical? What's Lurking?
Olivia Brumfield +3 more
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ADAMTS13 in arterial thrombosis [PDF]
, 2010 The aim of this thesis was to study the role of ADAMTS13 in arterial thrombosis, a disease that comprises both environmental and genetic factors. We determined ADAMTS13 in ischemic stroke patients and controls.
Bongers, T.N. (Tamara), Bongers, TN
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Characterisation of the ADAMTS13 Metalloprotease Domain [PDF]
, 2012 Von Willebrand Factor (VWF) is a large multi-domain plasma glycoprotein that is critical for normal platelet tethering during haemostasis. ADAMTS13 is a plasma metalloprotease that regulates VWF multimeric size/function by cleaving the Tyr1605-Met1606
Xiang, Yaozu
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Post‐Transfusion Purpura: A Clinical Case With Alveolar Haemorrhage
Respirology Case Reports, Volume 14, Issue 6, June 2026.We report a case of post‐transfusion thrombocytopenic purpura and alveolar haemorrhage in a woman after knee replacement surgery, occurring 7 days after transfusion of 20 mL of blood. This case was successfully treated with therapeutic plasma exchange and intravenous immunoglobulin.
Yordanka Yamakova +3 more
wiley +1 more source
Acquired TTP: ADAMTS13 meets the immune system [PDF]
, 2014 The majority of the patients affected by acquired thrombotic thrombocytopenic purpura (TTP) develop autoantibodies directed towards ADAMTS13 that interfere with its von Willebrand Factor (VWF) processing activity.
Sorvillo, Nicoletta +3 more
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International Journal of Laboratory Hematology, Volume 48, Issue 3, Page 521-530, June 2026.ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova +2 more
wiley +1 more source
Hairpin and allosteric regulation in ADAMTS13 [PDF]
Blood, 2019 In this issue of Blood , Muia et al 1 and Zhu et al, 2 using complementary approaches, provide important insights into the structure and function of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin-1 repeats, member 13), identifying critical structural features and interactions that allosterically regulate its proteolytic activity ...
openaire +2 more sources