Results 111 to 120 of about 9,301 (216)
Pilot study of ADAMTS13 activity and anti-ADAMTS13 antibodies stability
HämostaseologieIntroduction Thrombotic thrombocytopenic purpura (TTP) is a rare disease characterized by thrombocytopenia, microangiopathic hemolytic anemia, neurological disorders, renal dysfunction and febrility. TTP occurs due to ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 13) deficiency, which is most often a consequence of
A. Bogić +3 more
openaire +1 more source
Angiogenesis and the ADAMTS13-VWF balance [PDF]
Blood, 2017 In this issue of Blood , Xu et al describe a new function for the metalloprotease ADAMTS13 in blood vessel formation following brain ischemia. Using multiple approaches in mice, they show that ADAMTS13 is required for neovascularization and vascular repair following ischemic stroke.
openaire +2 more sources
Het ontrafelen van de rol van ADAMTS13 en anti-ADAMTS13 autoantilichamen in de pathofysiologie van trombotische trombocytopenische purpura [PDF]
, 2018 Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening disease, which is caused by a deficiency of the blood protease ADAMTS13.
Roose, E.
core
ADAMTS13 in the New Era of TTP
International Journal of Molecular SciencesThrombotic thrombocytopenic purpura (TTP) is a life-threatening, often immune-mediated disease that affects 2–13 persons per million per year. Hemolytic anemia, thrombocytopenia, and end-organ damage due to the formation of microthrombi are characteristic of TTP.
Anna Papakonstantinou +4 more
openaire +2 more sources
Scientific ReportsImmune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare and life-threatening blood disorder characterized by the formation of blood clots in small blood vessels. It is caused by antibodies targeting the A disintegrin and metalloprotease with
Heechun Kwak +13 more
doaj +1 more source
Scientific ReportsMesenchymal stem cells (MSCs) are known to facilitate angiogenesis and promote neo-vascularization via secretion of trophic factors. Here, we explored the molecular mechanism adopted by ADAMTS13 in modulating the expression of some key angiogenic markers
Srishti Dutta Gupta, Malancha Ta
doaj +1 more source
Anti-ADAMTS13 Autoantibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura
AntibodiesAutoantibodies to ADAMTS13 are at the center of pathology of the immune-mediated thrombotic thrombocytopenic purpura. These autoantibodies can be either inhibitory (enzymatic function) or non-inhibitory, resulting in protein depletion.
Michael R. Snyder, Robert W. Maitta
doaj +1 more source