Results 121 to 130 of about 14,009 (226)

The Highs and Lows of ADAMTS13 Activity

Journal of Clinical Medicine
Severe deficiency of ADAMTS13 (<10 iu/dL) is diagnostic of thrombotic thrombocytopenic purpura (TTP) and leads to accumulation of ultra-large vWF multimers, platelet aggregation, and widespread microthrombi, which can be life-threatening. However, the clinical implications of a low ADAMTS13 activity level are not only important in an acute episode ...
Rebecca J. Shaw, Simon T. Abrams, Samuel Badu, Cheng-Hock Toh, Tina Dutt   +4 more
openaire   +2 more sources

ADAMTS13 regulates angiogenic markers via Ephrin/Eph signaling in human mesenchymal stem cells under serum-deprivation stress

Scientific Reports
Mesenchymal stem cells (MSCs) are known to facilitate angiogenesis and promote neo-vascularization via secretion of trophic factors. Here, we explored the molecular mechanism adopted by ADAMTS13 in modulating the expression of some key angiogenic markers
Srishti Dutta Gupta, Malancha Ta
doaj   +1 more source

Frequency and Significance of HIV Infection among Patients Diagnosed with Thrombotic Thrombocytopenic Purpura [PDF]

, 2017
Background. Case series of patients with a diagnosis of thrombotic thrombocytopenic purpura (TTP) have reported different frequencies of human immunodeficiency virus (HIV) infection; some series suggest that HIV infection may cause TTP. Methods.
Benjamin, Melody, Dezube, Bruce J., George, James N., Kremer Hovinga, Johanna A., Lämmle, Bernhard, Terrell, Deirdra R., Vesely, Sara K., Voskuhl, Gene W.   +7 more
core  

Autoantibody-resistant ADAMTS13 variant [PDF]

Blood, 2021
openaire   +2 more sources

Precision medicine in thrombotic thrombocytopenic purpura: a narrative review. [PDF]

Ther Adv Hematol
Al-Shibly R, Ghasoub R, AlRasheed M, AlTourah L, Al-Eisa T, Yassin MA.   +5 more
europepmc   +1 more source

ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor in P. falciparum and P. vivax malaria. [PDF]

A deficiency in ADAMTS13 (a von Willebrand factor [VWF] cleaving protease) is associated with accumulation of prothrombogenic unusually large VWF multimers (UL-VWF) in plasma. We studied VWF release and proteolysis in patients with symptomatic Plasmodium
Syafruddin D
core  

ADAMTS13 ameliorates diabetic nephropathy by Nrf2/GPX4/eNOS signaling pathway. [PDF]

Ren Fail
Wang H, Guo J, Wang Q, Cai F, Jiang S, Fei L, Zhang G, Yu G, Li B, Zhou J, Li Z, Han F, Lai EY, Zhou S.   +13 more
europepmc   +1 more source

Complement activation in thrombotic thrombocytopenic purpura [PDF]

, 2014
Alvarez-Larran, Burns, Camous, Castellheim, Cat, Csuka, Dang, Ferrari, Ferrari, Ferrari, Galbusera, Gombos, Lotta, Lucisano Valim, Mitra, Moake, Monsinjon, Nauta, Noris, Ruiz-Torres, Sadler, Sims, Tedesco, Tsai, Valant, Wiedmer, Wright, Wu, Zwart   +28 more
core   +1 more source

Thrombotic microangiopathy overlap syndrome in pregnancy. [PDF]

Obstet Med
Han J, Min A, Desborough M, Harrington D, Pavord S.   +4 more
europepmc   +1 more source

ADAMTS13

Japanese Journal of Thrombosis and Hemostasis, 2006
openaire   +2 more sources