Results 71 to 80 of about 9,301 (216)

Clinical burden and healthcare resource use of congenital thrombotic thrombocytopenic purpura in England: A linked primary and secondary care data analysis

British Journal of Haematology, Volume 209, Issue 1, Page 248-256, July 2026.
Summary Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra rare haematological disorder. This study aimed to estimate the clinical burden, healthcare resource use (HCRU) and associated costs of cTTP in England using primary and secondary care data. A retrospective cohort study was undertaken using the Clinical Practice Research Datalink (
Erin Barker, Will Lester, Heather Riley, Monica Garrett, Amie Padhiar, Annie Berkley, Sudhakar Manne, Umesh Doobaree, Oliver Heard   +8 more
wiley   +1 more source

Longitudinal assessments of plasma ADAMTS13 biomarkers predict recurrence of immune thrombotic thrombocytopenic purpura

Blood Advances, 2019
: Immune thrombotic thrombocytopenic purpura (iTTP) is primarily caused by immunoglobulin G (IgG)–type autoantibodies that bind and inhibit plasma ADAMTS13 activity and/or accelerate its clearance from circulation. Approximately 50% of patients with iTTP
Jingrui Sui, Wenjing Cao, Konstantine Halkidis, Mohammad S. Abdelgawwad, Nicole K. Kocher, Bryan Guillory, Lance A. Williams, Radhika Gangaraju, Marisa B. Marques, X. Long Zheng   +9 more
doaj   +1 more source

Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura. [PDF]

PLoS ONE, 2016
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy linked to a deficiency in the metalloprotease ADAMTS13. In the current study, a novel mouse model for acquired TTP was generated to facilitate development and ...
Louis Deforche, Claudia Tersteeg, Elien Roose, Aline Vandenbulcke, Nele Vandeputte, Inge Pareyn, Elien De Cock, Hanspeter Rottensteiner, Hans Deckmyn, Simon F De Meyer, Karen Vanhoorelbeke   +10 more
doaj   +1 more source

Real-world data of thrombotic microangiopathy management: The key role of ADAMTS13 activity and complement testing

Thrombosis Update, 2021
ADAMTS13 (A Disintegrin and Metalloprotease with ThromboSpondin type 1 motifs) activity is a key tool in differential diagnosis of thrombotic microangiopathies (TMAs).
Eleni Gavriilaki, Eudoxia-Evaggelia Koravou, Thomas Chatziconstantinou, Christina Kalpadaki, Nikoleta Printza, Maria Ximeri, Anna Christoforidou, George Karavalakis, Maria Kaliou, Vassiliki Kalaitzidou, Iliana Tassi, Maria Tzellou, Tasoula Touloumenidou, Apostolia Papalexandri, Maria Papathanasiou, Antonia Syrigou, Anna Kioumi, Maria Liga, Georgia Kaiafa, Alexandros Spyridonidis, Eleni Kapsali, Konstantinos Kollios, Eudokia Mandala, Efthymia Vlachaki, Panagiotis Tsirigotis, Eleni Papadaki, Chrysavgi Lalayanni, Ioanna Sakellari, Achilles Anagnostopoulos   +28 more
doaj   +1 more source

Platelet Transfusion Is Associated With Increased Thrombosis and In‐Hospital Mortality Among Patients Hospitalized With Platelet Consumptive Disorders

European Journal of Haematology, Volume 117, Issue 1, Page 245-257, July 2026.
ABSTRACT Background Platelet transfusion is commonly used to reduce bleeding risk in platelet consumptive disorders. However, platelets may also promote thromboinflammatory pathways, and contemporary data evaluating the association between platelet transfusion, thrombosis, and mortality in this population are limited.
Manas Pustake, Shubhangi Deoker, Veeravenkata Garikiparthy, Kunal Sharma, Lakshmi Kattamuri, Abhizith Deoker, Abhinav Deol   +6 more
wiley   +1 more source

ADAMTS13 expression in mouse kidney. [PDF]

, 2013
ADAMTS13 expression was investigated by immunohistochemistry in mouse renal tissue. Staining was observed in the kidney of Adamts13+/+ wild-type mice on the mixed 129X1/SvJ and C57BL/6 genetic background (Panel A).
David Motto (349293), Matthias Mörgelin (109607), Anne-lie Ståhl (349291), Minola Manea-Hedström (349298), Peter Mathieson (349296), Diana Karpman (67915), Ramesh Tati (349287), Simon Satchell (349295), Ann-Charlotte Kristoffersson (349289)   +8 more
core   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

ADAMTS13 and Myocardial Infarction: A Literature Review [PDF]

, 2022
Background: Myocardial infarction (MI) is the most common cause of death worldwide. Important modifiable risk factors have been unraveled and preventive measures established, but the disease burden remains substantial.
Edvardsen, Magnus Sandvik
core  

ADAMTS13 activity decreases in the early phase of trauma associated with coagulopathy and systemic inflammation: a prospective observational study

Thrombosis Journal, 2021
Background We conducted a prospective observational study for investigating the changes in the 13th member of a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS13) and its association with the coagulofibrinolytic response in ...
Hironori Matsumoto, Jun Takeba, Kensuke Umakoshi, Satoshi Kikuchi, Muneaki Ohshita, Suguru Annen, Naoki Moriyama, Yuki Nakabayashi, Norio Sato, Mayuki Aibiki   +9 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source